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Message started by GoodScienceForYou on Jan 11th, 2011 at 4:04pm

Title: PEER REVIEWED AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Jan 11th, 2011 at 4:04pm
Next in AlanAFC’s line of “absolute” evidence we have the fossil record as he put it:

“the fossil record with transitional forms”


When I was very young, my father, God bless him, taught me to never believe anyone. That all people are full of agendas and that I should find out what is true and what “works” for myself. 

It is funny but that is what the greatest people of all time teach, but for some human reason people are like sheep and lemmings and need to believe and follow other ignorant humans and their ridiculous beliefs.  I am finding that beliefs are a form of delusion to protect oneself from the reality of the situation.

I was introduced to this idea of fossils showing evolution back in high school at 14 years old, and I started to study this “very interesting idea” for myself.   It didn't take long to realize that these flawed emotional humans, who called themselves "professors" were projecting belief on fossils, because there was no tie between any of the fossils and the standards for my acceptance were not met. (There was also very little if any DNA evidence as DNA was just discovered in the late 50's)

My standards for scientific acceptance are absolutely irrefutable evidence that this is real, requires no indoctrination into a belief system.  Since they could not produce this evidence, and all they had were slogans of belief, I realized quickly these were weak minded humans who were only on a quest to show their religious belief in this pseudo science.

The things that really turned me off were the cartoons of these ape men that were obviously fabricated only from the minds of the believers.  I still remember looking at these fossil photos in the “science books” and then looking at the cartoon depiction of these creatures as “they must have looked”.   The cartoons didn't match the fossils, that were distorted and had no indication of tissue at all.

There was and still is absolutely no way for them to recreate these “millions of year old” creatures by any human knowledge of them.  The skin hair, muscles, tendons, lips, eyes, ears are simply not existent on fossils.  Yet these believers would place those body parts on these distorted fossils and they would “straighten out the fossils”.   You would have to have “fallen off a turnip truck” to believe this religious nonsense. 

I put this “crap” aside and proceeded to get degrees and knowledge in real science. Science that never fails to offer evidence for the theory and that only points to the theory.   I learned that when ALL OF THE EVIDENCE POINTS TO THE THEORY AND ONLY TO THE THEORY WITH NO OTHER PLAUSIBILITY, YOU ACTUALLY HAVE A SCIENCE THAT FUNCTIONS. This is what I call “functional science”.

I studied physics, math, electronics; these are functional sciences as you can tell by the computer you are using today.  I can design a circuit board and send it to China and it will work the same if it was made in the US  or any country. To be quite simple you know it is science,   because it is a functional scientific theory one that works and it is required to show everyone that it works, not just the religious believers who are indoctrinated.

We can see that The theory of Evolution is a non functional science, because it has never produced as single useful idea in medicine, biology, nor in understanding life.  It has never produced any good for mankind.  It is not testable, and therefore is not science.

You cannot test something that  has no evidence of being true.

You can look at all the evidence and determine what is obvious if you have no prejudices from some ideology or religion.

The fossil record is obviously and clearly not depicting any form of evolution towards greater complexity, that fits any part of the theory that simple life has magically evolved into complex life. Fossils are so full of contradiction that they invalidate themselves.  There is absolutely no credibility in fossil evidence showing evolution of simple life towards complex. The opposite is only shown in DNA and in the creatures we have living today where we can test DNA.

The first thing for any scientist, real scientist to do is to define what constitutes evidence for “transitional fossils”.   If you let someone else define what evidence is, you are just allowing them to brainwash you into their "religious" ideas, even if they are the town expert and have multiple PhD's.

If creatures “evolve” towards a new life form, like a one celled creature that evolves into a multi cell creature with arms, legs, feet, eyes, brain, like a human being, then you would see evidence of this in the physical world today.

There is none.

I have looked at all the evidence and there are no transitional fossils on this planet, indicating a slow transition of features in a direction towards more complexity more fitness or more intelligence.  Only if you are a believer in this idea do any of these fossils look like they may be a transition.  REPEAT: it is only if you  are already a believer that any of these fossils seem like transitional.

And these people are so adamant that fossils are so "clear" to them.  Use your brain and see if you see any clarity in them.

If you define transitional as having slight steps in the direction towards the more complex creature you can then think it is the transition.   That means that there would be at least ONE set of  complete fossils out of 250,000,000 that would show gradual steps of the formation of features towards and only towards more complex and morphological changes. 

We only see completely formed creatures with full arms legs, fins, spine, heads, etc. Then we only see creatures degrading in features.  It looks like complete body parts or gene to cell replication function has been shut off.   There are no partially developed “anything’s”. There are no body parts that show any transitions. AND all of the evidence points only to degradation of existing creatures.  All we see is the ancestors were much stronger than the de-evolved species from any genetic lineage.

What I have discovered is that in the hundreds of people whom I have asked about this, they all think that a completely finished creature is somehow a transition.  The only way this can be “real” to them is by indoctrination and wanting to believe in this.  Meaning, they are not guarding their intelligence against these false authorities, who are just believers in this religious mythology of evolution.

Also, you will see them try to tie in obvious facts and using nothing but inference use these separated, and purposely separated, facts as evidence for evolution.  You never see them take each piece of evidence and compare them to each and every other piece of evidence, because they are not capable of doing that.  DNA shows no form of "evolution" because it only show absolutely clear and irrefutable evidence of reduction in fitness over time.

When you compare all the evidence to a premise, it better fit with the premise, that with each piece you will see that the evidence tells us a totally different story than some magical process that magically improves creatures from a simple life form to a complex life form.  This has never happened.

When the only evidence is wishful thinking projected on fossils, with absolutely no way to verify any of it, that is not science.  When all the evidence and I mean all of it is simply the "opinions of believers", and they can't show us any verifiable "concrete" physical evidence to back it then, I call it the mythological religion of Evodelusionism.



If you still don't understand, instead of just laying down for this faith based belief, ask questions.  These people teaching this stuff are not scientists, no matter what they think they are; They are not.  In my opinion they are the paid priests of this pseudo religion. If you get paid to teach this crap to people, you  need to find something ethical to do with your life.

I am sorry but when I come across a old time professor of this nonsense who woke up one day and realized it was all nonsense, that in his entire life dedicated to science and teaching this he has not see any evidence that was conclusive of any "improvements" increases, new genes, etc.
It is a little late, to go back and take back all the nonsense he taught to those young people.   The emotional regrets are horrible and haunt you until you die.  So you better know what you are doing when you teach others.

New genes are required for evolution and new cells with new functions having beneficial results.  There's none of that shown.

Title: Re: AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Jan 31st, 2011 at 9:03pm
AlanCFA next “proof” of evolution

“anatomical and molecular vestiges”

This is just about the easiest to refute as evidence for any form of “evolution”.

This is the part of evolution that is nonsense "Evolution:  "that theory which sees in the history of all things organic and inorganic a development from simplicity to complexity, a gradual advance from a simple or rudimentary condition to one that is more complex and of a higher character." Webster's Encyclopedic Dictionary of the English Language. "

In order to show evolution, you  must show progress towards useful features that are developing, not useless features that are not used because of atrophy.

Atrophy is evidence against evolution and absolutely clear evidence towards atrophy and anti-evolution.

If a feature was there and now it is gone is a sign that creatures were more advanced with more physiological features used for survival that are now not used any more.

In order to show “evolution” or progress towards the more advanced or more complex you  need to show features which are developing.

Title: Re: AlanCFAs idea of evidence for evolution "atavisms"
Post by GoodScienceForYou on Jan 31st, 2011 at 9:09pm
"atavisms"

The meaning of atavism is “anatomical and molecular vestiges”.  So for someone to imply that these are separate "things" in their "long list of reasons" is stupid. I mean really pathetic and shows they need this for emotional reasons.

This is easy to refute.  Any feature that reoccurs from the past is not new. If an Atavism is triggered it is still not new.

In order to show any form of evolution, you  must show NEW features that made themselves from coding that has never existed.

This is more "proof" of anti-evolution or degeneration as is shown in all DNA evidence.

Title: Re: AlanCFAs idea of evidence for evolution "ontongeny"
Post by GoodScienceForYou on Jan 31st, 2011 at 9:13pm
"ontongeny"
Here are the various meanings of this word from science:

"the development of defects in an embryo"
"the failure to develop some part or organ"
"the process of growth in plants"
"the science that studies living organisms"


Again this only talks about existing traits developing within the live creatures.  In order to show evolution you must show only NEW traits developing that have never been seen in any of the species ever at any time in history.

Clear?

Title: Re: AlanCFAs idea of evidence for evolution "anatomical and molecular parahomology"
Post by GoodScienceForYou on Jan 31st, 2011 at 9:26pm
"anatomical and molecular parahomology"

In DNA this is the idea that any showing of similar DNA automatically is evidence for genetic linking from the original parent of all species the great granddaddy of all life.  This part of this science is full of inferences.

For instance there is a tiny and  I mean tiny segment of DNA found in one species of fish that is similar to humans. So this is automatically believed as evidence that we evolved from fish. 

There are only 20 amino acids to make life cells with.  The odds of the design showing redundant use of the same type of cells to make "muscles" for instance, is about 100% with NO genetic connection at all.  Muscles require a cell that contracts in response to impulses from nerves.  There isn't many ways to make that.

This does not warrant any further discussion at all.  It is ridiculous crap "pseudo science" and a stretch of the imagination.

It goes along with the idea that fools think that any similarity of use, appearance can only mean a direct genetic linage link.

This is utterly ridiculous and in fact all that I have seen of this idea in fossils of the "ancient version" of the creature are shown to have far more usable features and the "homology" becomes more complex as you go back in time.

It is evidence of anti-evolution or the continual degradation  of all species. 

Here is a photo of the ancient saber tooth tiger the "determined" parent of the cat species, by "homology".  It looks like a cat but it is far more powerful, far more able to survive and has many more features that modern cats, lions, tigers, leopards, panthers and all the cats. All of the "cats" devolved from this amazingly far more complex life form.


Title: Re: AlanCFAs idea of evidence for evolution "anatomical and molecular convergence"
Post by GoodScienceForYou on Jan 31st, 2011 at 9:38pm
"anatomical and molecular convergence"


When a creature has anti-evolution and is degrading in its complex functions as is shown in ALL the evidence you will see what I call genetic and physical splits.  This happens when the creatures do what is known as "speciation". They split off from the original family of the parent of the genetic lineage.

You have to go backwards with this in time to realize that the parent of all speciation splits was much stronger, more complex and far more advanced in terms of survival and genetic features for survival.  The horse is another example.

You will notice that the oldest of the "horse" as it is believed to be from paleontology and what they think is the ancient horse, that this creature has far more complex bone structure in its legs. As it goes along to the "modern" horse it has lost many bones and flexibility in the legs. This has cause the horse to be more limited, rather than more complex.

Even the ancient teeth look better.
Horseevolution__1_.png (357 KB | 520 )

Title: Re: AlanCFAs idea of evidence for evolution "suboptimal function"
Post by GoodScienceForYou on Jan 31st, 2011 at 9:51pm
"sub-optimal function"

NOTE: This one is so damned funny that I had to quote the site that all the Evotards use for this.  In the first paragraph they clearly define "anti-evolution" or loss of good genetic engineering as the creatures "degrade" from the more "optimal" to the "sub-optimal".

This is the MOST compelling evidence for anti-evolution or gradual degrading of the best genetic engineering to the more defective genetic engineering we see today that I have ever seen and that we can see today. The famous "The Left Recurrent Laryngeal Nerve" is totally evidence for genetic degradation.  See the video below. These people are "nuts" by the way in not being able to see the obvious, because they are brainwashed into seeing things BACKWARDS. 

=========================================

From http://www.talkorigins.org/faqs/comdesc/section3.html
Evolutionary opportunism also results in suboptimal functions and structures. As stated before, in gradually evolving a new function, organisms must make do with what they already have. Thus, functions are likely to be performed by structures that would have been arranged differently (e.g. more efficiently) if the final function were known from the outset. "Suboptimality" does not mean that a structure functions poorly. It simply means that a structure with a more efficient design (usually with less superfluous complexity), could perform the same final function equally well. Suboptimal structures and functions should have a gradualistic, historical evolutionary explanation, based on the opportunistic recruitment of ancestral structures, if this history is known from other evidence (e.g. if this history is phylogenetically determined by closely related organisms or fossil history)."






http://www.youtube.com/watch?v=slA5I3tcJR4

Title: Re: AlanCFAs idea of evidence for evolution "protein functional redundancy"
Post by GoodScienceForYou on Jan 31st, 2011 at 10:30pm
"protein functional redundancy"

There are only a very few amino acids available to make living tissue from, so OF COURSE it will be used in different creatures to make similar body parts.  And this is also a repeat or another of the same nonsense I covered already.
It seems that repeating the same concepts using different wording somehow adds more "evidence".  It is the same evidence and the same answer.

Look at the chart and tell me how many amino acids do you see?
We live on a tiny finite little planet with fixed resources.
We do not have infinite resources to build body tissue from.



[I had to remove my sarcasm, because this is utter nonsense]  There is no possible evolution of any simple life that goes from simpler to more complex because just the opposite is truth.  All life forms started out stronger, more complex and more able to survive, with less genetic diseases and far better genetic engineering.

And this idea that fish share proteins with humans in the DNA is supposed to prove that humans evolved from fish.
This is such a stretch of the imagination that it makes me laugh how stupid people can be.
Check this out. They think that a tiny section of DNA that is close to human in fish is proof of fish evolving into humans:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720184/pdf/1404.pdf/?tool=pmcentrez

========================================

In order to show there is similarity in genetics to tie creatures together, you need one huge amount of data.  This is obvious in the Chimp and Human DNA comparison.


Here is more evidence that Chimps are genetic reduction from the Ancestor Human Genome, which was far more fit than now.

Ancient, more complex, more intelligent, and way more healthy,  Humans ( a far more superior and intelligent human species) are the more complex common ancestor to both modern humans and chimps and primates.  It is exactly, again, the opposite of the belief.

In all the evidence we have in biology DNA Genetics there is only a reduction of gene functions and a total gradual degradation of the original "excellent genetic engineering".

Realizing that chimps are the ancestor of a far more complex and far better made human that has degraded is simple to see in this supposed proof of "evolution".
Chimps have never flourished are relatively young species very little evidence of them in the ground and they are now going extinct.  Chimpanzees have less than 600 left in the wild and the rest are in sanctuaries or being used in horrible labs like this;

http://www.youtube.com/watch?v=u9gr65wKNXY

" Importantly, Hubert Yockey has done a careful study in which he calculated that there are a minimum of 2.3 x 1093 possible functional cytochrome c protein sequences, based on these genetic mutational analyses (Hampsey et al. 1986; Hampsey et al. 1988; Yockey 1992, Ch. 6, p. 254). For perspective, the number 1093 is about one billion times larger than the number of atoms in the visible universe. Thus, functional cytochrome c sequences are virtually unlimited in number, and there is no a priori reason for two different species to have the same, or even mildly similar, cytochrome c protein sequences.

In terms of a scientific statistical analysis, the "null hypothesis" is that the identity of non-essential amino acids in the cytochrome c proteins from human and chimpanzee should be random with respect to one another. However, from the theory of common descent and our standard phylogenetic tree we know that humans and chimpanzees are quite closely related. We therefore predict, in spite of the odds, that human and chimpanzee cytochrome c sequences should be much more similar than, say, human and yeast cytochrome c - simply due to inheritance.

Confirmation:

Humans and chimpanzees have the exact same cytochrome c protein sequence. The "null hypothesis" given above is false. In the absence of common descent, the chance of this occurrence is conservatively less than 10-93 (1 out of 1093). Thus, the high degree of similarity in these proteins is a spectacular corroboration of the theory of common descent. Furthermore, human and chimpanzee cytochrome c proteins differ by ~10 amino acids from all other mammals. The chance of this occurring in the absence of a hereditary mechanism is less than 10-29. The yeast Candida krusei is one of the most distantly related eukaryotic organisms from humans. Candida has 51 amino acid differences from the human sequence. A conservative estimate of this probability is less than 10-25."

From http://www.talkorigins.org/faqs/comdesc/section4.html

What this means is mathmatically it is impossible for chimps and humans to not be related by genetics.  That cannot be refuted and it follows exactly what the DNA evidence shows towards Anti-Evolution, or de-evolution.  There is no sign shown in DNA that any creature has gained any new features but has only lost features and has more defects. PERIOD.

Chimps are from the same "super human species" as modern humans and both have de-evolved along separated lines.
I think that Chimps lived in a rapid genetic degradation zone of the planet with more toxins and much more natural radioactive isotopes.
When you examine the DNA of Chimps and humans  you see clearly the remnants of humanness in chimp DNA and you can see the losses in brain capacity, and the abilty to speak and very limited reasoning abilty.

If anything Chimps are a message from the "Genetic Engineer" of what will happen if you don't follow the instruction manual for genetic preservation and holding on to what good is left in human intelligence.

http://www.youtube.com/watch?v=VbgenlSg198

I think that the pagan religion of Evodelusionism is evidence of human de-evolution.  Nobody with any intelligence can actually think there is such scientific garbage as random causes and genetic information causing genetic engineered structures that magically appear by accidents.

When a person drives a car into that pole and smashed the front-end of their car, did it improve the car?  If you  keep smashing it (deleterious mutations) eventually "it will turn into a truck", by this logic. 

How did you allow this sort of logic?  How can anybody be that stupid.  If you understand anything about science and engineering , you will realize quickly how illogical this whole religious ideology (Evodelusionism)  belief system is. 

============================================
HOW MANY AMINO ACIDS ARE THERE IN THIS CHART?
It is a very small number and so it is recycled throughout all organic life.




Title: Re: AlanCFAs idea of evidence for evolution The Gecko
Post by GoodScienceForYou on Feb 1st, 2011 at 1:18am
"The gecko looks exactly like its modern-day relatives although researchers at the Oregon State University estimated its age at 100 million years. The gecko, which was found in Burma (Myanmar), is said to be 40 million years older than the oldest known gecko fossil. It was thought to have lived in the lower Cretaceous before the heyday of Tyrannosaurus rex."


The Gecko has amazing genetic engineering and is the predecessor of snakes.  It has feet that can walk on glass upside down.  It is far more genetically advance than most any of the reptiles.  It is also much older and is a prime example of genetics and that all the spin offs with gecko genes are degraded from them.
Snakes show loss of legs. The do not show any idea that they are "developing" legs. That does not follow any evidence nor any DNA evidence.




Title: Re: AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Feb 11th, 2011 at 12:57pm
It is absolutely clear in evidence that there is no "correcting" or "fixing" enfluence in any creature. They are all losing gene fucntions and are less complex because of this.

70% of the thing this "science" calls "mutation" results in damage to the genome.  Considering that this is happing all the time. Then just by this statistic alone negates the possibility of any general NET increase in fitness of any creature.

Because these scientists are not looking for the cause of any form of "positive" gene expression they cannot say where these very few positive expressions come from.  They pull out the "magic" card out of their ass and say they are "random mutations".  It is highly unlikely that any positive results come from any accidental gene change that would fit with the completed genetic structure of any human.

The loss of gene function is de-evolutoin or anti-evolutoin. Any "positive" gene improvement was most likely already in the human population.  In order to say without any doubts where these come from, they would have to do the work to check the DNA of many generations backwards from the specimen sample DNA thought to have "improved" DNA.

"Loss of the CBX7 gene expression correlates with a highly malignant phenotype in thyroid cancer."
http://www.ncbi.nlm.nih.gov/pubmed/18701502
==========
http://www.ncbi.nlm.nih.gov/pubmed?term=Loss%20of%20gene%20function

I was going to post every gene loss that represents de-evolution, but there are over 80,000 articles on this. on the government web site.

The point is there is no evolution, there is only a continual degradation of the human genome and all genomes.

There is no magical process that "fixes" or "improves" gene functions.  The only thing that will fix it is "intelligence" that steps in to fix these imperfections.  It took genetic engineering to produce all the life on earth, and it takes genetic engineering to fix it. 

Only a brainwashed person who is using archaic, Evodelusional, ideas of evolution could not see this.

When you read articles realizing that there are no new gene expressions bringing any improvements by magical "evolution" process that have never been documented, we can start to get free from delusional archaic concepts that retard science.

http://www.cell.com/abstract/S0092-8674(05)00541-6


http://www.nature.com/onc/journal/v23/n13/full/1207395a.html

http://www.pnas.org/content/87/19/7762.full.pdf

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228234/pdf/brjcancer00186-0067.pdf

http://clincancerres.aacrjournals.org/content/9/3/1013.full

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6PJN-51K90TG-8&_user=10&_coverDate=03/31/2010&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_searchStrId=1638782468&_rerunOrigin=google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=1d5b05700e8d1ebe276bdcc2f487de0e&searchtype=a

http://jcem.endojournals.org/cgi/content/full/87/3/1262

http://en.wikipedia.org/wiki/Mutation

http://www.ncbi.nlm.nih.gov/pubmed/20093486

http://www.jbc.org/content/284/20/13348.full


Honest Geneticists:  Nothing in common on eye development.
http://genome.cshlp.org/content/14/8/1555.full

http://www.journals.elsevierhealth.com/periodicals/ajpa/article/S0002-9440(10)60422-1/abstract

http://www.genetic-future.com/2008/03/why-do-genome-wide-scans-fail.html

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T36-3YS2BGN-48&_user=10&_coverDate=11/20/1995&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_searchStrId=1638793868&_rerunOrigin=google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=2c7a7ab8524d1f7775d955073dd60678&searchtype=a

Type 1 Diabetes is an auto immune disease in people with powerful immune systems that destroy the islets. 
http://diabetes.diabetesjournals.org/content/53/9/2281.full

http://www.newsrx.com/newsletters/Genomics-and-Genetics-Weekly/2004-05-28/05282004333152JW.html

http://erc.endocrinology-journals.org/cgi/content/short/17/2/383

http://en.wikipedia.org/wiki/Cystic_fibrosis

http://science.jrank.org/pages/2949/Gene-Mutation.html

http://www.ajcn.org/content/88/1/125.full.pdf

http://www.wistar.org/Herlyn/Pub%20PDFs/McArdle2005.pdf

Excellent basic article on "mutation".
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/M/Mutations.html

http://www.springerlink.com/content/p654p087275377n3/

Interesting article on Gene expression.
http://employees.csbsju.edu/hjakubowski/classes/ch331/bind/olbindtransciption.html

http://www.chd.ucsd.edu/seminar/documents/Varki.2008.NRG.pdf

http://www.ncbi.nlm.nih.gov/pubmed/3333352?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1377697/pdf/9915938.pdf

http://en.wikipedia.org/wiki/List_of_genetic_disorders

http://nar.oxfordjournals.org/content/37/18/6184.full.pdf+html
Look at the DNA charts on the primates, all of them are younger and have diminished human genomes.  There is noi way for humans to evolve from a species that is at least 500,000 years younger by the radiometric dating methods.

Title: Re: AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Feb 12th, 2011 at 11:36am
http://anthropology.net/2008/03/20/a-multivariate-analysis-of-orrorin-tugenensis-and-the-ancestry-of-bipedalism/

We also have a recent finding of MODERN humans in Israel from 400 to 500 thousand years ago. This fact destroys the idea that we "evolved" from Africa only. The so called MODERN human before that were dated at just under 200 thousand years in Africa. 

Darwin based his justification for his cultural brainwashing that English people were evolved and that blacks were low and poor evolved, like animals, left over from Africa.
Darwin was an idiot, like all Evotards.

Title: Re: AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Feb 14th, 2011 at 12:20am
http://www.accessscience.com/IOW/iow.aspx?iowID=16

http://www.thepoultrysite.com/articles/990/darwin-was-wrong-about-the-wild-origin-of-the-chicken

DNA shows this was the speciated cousin from the  predecessor of the chicken. 

It is far more able to survive in the wild than its later versions.
Another "notch in the handle" on killing evolution as any idea of reality.

http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000010



Title: Re: AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Feb 14th, 2011 at 10:38pm
@Draugh39 "mean that we branched off from them!!" Or they branched off from US, is what follows the evidence. And as time goes on we gathered more. It is pure logic, and is objective logic, not based on any faith or ideas of "evolution". I don't believe in anything that people teach, I find the truth for myself.

GoodScienceForYou 20 seconds ago
@Draugh39 By the way, I just cut and pasted the top of the article for you to google much easier. If you put it in the google box that way you can't miss it. Don' t be a jerk. I was impressed with you until your denial methods of what is obvious. I know it goes against your faith and belief, but it IS what is in the evidence. There is never any NET increase in complexity any any genetic lineage as it goes through time. This is shown in DNA.

GoodScienceForYou 3 minutes ago
@Draugh39 Having more insertion points at this time means that we have gained in retro virus, because of our life styles. We are exposed to many more virus infections. You are angry, because you are not ready to get clear of these ideologies of your belief. What you do is based on faith and is not following the real evidence.

Chimps are much younger than humans and there is way to much genetically close for anything else. The others are not much of an issue and they are also all younger.

GoodScienceForYou 7 minutes ago
@GoodScienceForYou

You don't even understand what you read!? The ERV shows that we have more insertion points than the apes of these specific types retro viruses. The ERV can't simply disappear which mean that we branched off from them!!! Boy for a person that claims to have an IQ of 180 you do show an utter lack of understanding.

By the way a reference is written as follows: Author, Journal name, year of publication, pages. You don't put the address

Draugh39 12 minutes ago
@Draugh39 It only works ONE WAY. There's no evidence of any increase in gene function. There are only significant diminished gene expressions shown in DNA. There are over 2000 known genetic illnesses in the human genome. They don't magically fix themselves by any mystical causes. They are permanent and can only be removed by genetic engineering. This is OBVIOUS. and if you can't see it, your education is in the way.

"The only thing that interferes with my learning is my education."A Einstein

GoodScienceForYou 29 minutes ago
WOW! You believe this? This is what you are admitting too?

Don't end your search here folks. Keep an open mind and explore all things. Then come to a conclusion becuase this is straight bovine. You are worth sooo much more than this crud.

God bless

highwaysandbyways 30 minutes ago
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@Draugh39 The old world monkey have fusions of the human genomes chromosomes and have 2 million less base pairs. They also carry the ERV markers. This shows a direct genetic lineage from humans as their common ancestor. They are much younger than humans.

How is it possible for humans and chimps to have a magical common ancestor when they are so close genetically and the chimp is way younger as a species on this earth. Chimps are obviously the result of a diminished human genome.

GoodScienceForYou 37 minutes ago
@Draugh39 Accurate and efficient reconstruction of deep phylogenies from structured RNAs Roman R. Stocsits 1, *, Harald Letsch 1 , Jana Hertel 2, *, Bernhard Misof 3 and Peter F. Stadler 2,4,5,6, Look closely at the DNA ties to the primates, realizing that all of them are much younger than humans an all have diminished human genomes.
GoodScienceForYou 48 minutes ago
@Draugh39 I am tired of being told to believe in science by people who don't even use the scientific methods.

I have been a scientists all of my adult life, and I would never get a degree in some ideology that has no evidence to back it. There is no magical processes, nor mystical causes in genetics. There is no magic "random mutations" because random violates the first rule of science, CAUSE and RESULT or Cause and Effect. There is no magic that fixes genomes. PERIOD.

GoodScienceForYou 1 hour ago
@Draugh39 If you want to indoctrinate into an ideology, the best place is in the classroom. If you want to control the indoctrination change the definitions to match the belief. They realized that evolution is not towards any form of increased complexity, so they use the definition of genetics to replace it with. However the foundation of this etymology means towards the more complex. Computers evolve, humans don't


@Draugh39 I am tired of being told to believe in science by people who don't even use the scientific methods.

I have been a scientists all of my adult life, and I would never get a degree in some ideology that has no evidence to back it. There is no magical processes, nor mystical causes in genetics. There is no magic "random mutations" because random violates the first rule of science, CAUSE and RESULT or Cause and Effect. There is no magic that fixes genomes. PERIOD.

GoodScienceForYou 1 hour ago
@Draugh39 If you want to indoctrinate into an ideology, the best place is in the classroom. If you want to control the indoctrination change the definitions to match the belief. They realized that evolution is not towards any form of increased complexity, so they use the definition of genetics to replace it with. However the foundation of this etymology means towards the more complex. Computers evolve, humans don't

GoodScienceForYou 1 hour ago
SPEAK FOR YOURSELF!!!!

StLukey7 2 hours ago
@Draugh39 third part on the chicken; 4 Hendrix Genetics, Breeding Research & Technology Centre, Boxmeer, The Netherlands, 5 Istituto Nazionale per la Fauna Selvatica, Laboratorio di Genetica, Ozzano Emilia, Italy, 6 IFM Biology, Linköping University, SE-58183 Linköping, Sweden

GoodScienceForYou 2 hours ago
@Draugh39 second part on the chicken: 1 Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden, 2 INRA, AgroParisTech, UMR1236 Génétique et Diversité Animales, Jouy-en-Josas, France, 3 Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden,

GoodScienceForYou 2 hours ago
@Draugh39 Identification of the Yellow Skin Gene Reveals a Hybrid Origin of the Domestic Chicken. Jonas Eriksson1, Greger Larson1, Ulrika Gunnarsson1, Bertrand Bed'hom2, Michele Tixier-Boichard2, Lina Strömstedt3, Dominic Wright1, Annemieke Jungerius4, Addie Vereijken4, Ettore Randi5, Per Jensen6, Leif Andersson1,3*

GoodScienceForYou 2 hours ago
@Draugh39 You can go and get the rest. And read my explanations for my conclusions.

GoodScienceForYou 2 hours ago
@Draugh39 I just gave you two. I have the one on the laryngeal nerve as well. 29+ Evidences for Macroevolution

Part 3:

Opportunism and Evolutionary Constraint

Copyright © 1999-2004 by Douglas Theobald, Ph.D.

GoodScienceForYou 2 hours ago
@Draugh39 29+ Evidences for Macroevolution

Part 4:

The Molecular Sequence Evidence

Copyright © 1999-2004 by Douglas Theobald, Ph.D.

GoodScienceForYou 2 hours ago
@Draugh39 remainder of heading: 2

The University of Queensland, Institute for Molecular Bioscience and Australian Zebrafish Phenomics Facility, Brisbane, QLD

4072, Australia

GoodScienceForYou 2 hours ago

Title: Re: AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Feb 14th, 2011 at 10:38pm
@ScientificBob 2. a afaransis, a africanus, homo erectus, homo habilis, homo ergaster, homo neanderthal,... how many do you want? These are not enough for evidence. The common belief is that homo Erectus is the missing link from 1.8 to 1.3 million years ago, but the oldest upright hominid is 6.1 million years old.

Neanderthal DNA shows Chimp and Human DNA and That humans mated with Neanderthals. Read up on this. The more we know the more Evodelusionism is gone.

GoodScienceForYou 9 hours ago
@GoodScienceForYou 1. the question was about transitional, not "missing links"

2. if a new fossil is found of say a "transitional" state after homo erectus, guys like you will begin yapping about the "missing link" between homo erectus and that newfly found fossil

3. fossilisation is rare

4. even without a single fossil, evolution is more then proven in genetics.

5. "missing links" deal with evolutionary HISTORY, not with evolutionary biology.

So your point invalid.

ScientificBob 9 hours ago
@ScientificBob Guys like you use faith and belief to fill in the blanks. I use evidence and the DNA is fantastic evidence for only DE-EVOLUTION.. All creatures are losing gene functions and we can easily see this in the DNA. Fossilization is not rare. We have samples of over 200 million fossils from most creatures that have ever lived. WE have 88% of the non bird, NOW LIVING, vertebrates as fossils and the original looks more fit than we have now. Go look! You cannot use faith and belief!!

GoodScienceForYou 7 hours ago
@ScientificBob 1 of 2 What I recommend is to get away from the indoctrination and find out what is going on. We have all the evidence we need now to point in the opposite direction to "evolution". It is an archaic idea in science, just like "the world is flat".

GoodScienceForYou 7 hours ago
2 of 2 Evolution: "that theory which sees in the history of all things organic and inorganic a development from simplicity to complexity, a gradual advance from a simple or rudimentary condition to one that is more complex and of a higher character." Webster's Encyclopedic Dictionary of the English Language.

There is NO evidence of this in modern biology, genetics, nor in the fossil record. It is exactly the opposite.

GoodScienceForYou 7 hours ago
@GoodScienceForYou

You are *deliberately* using the wrong Webster definition as a straw-man.(And OED is a better reference anyway)

"Evolution - a theory that the various types of animals and plants have their origin in other preexisting types and that the distinguishable differences are due to modifications in successive generations; also : the process described by this theory." (Webster latest eddition)

You truly are a dishonest person.

Draugh39 5 hours ago
@Draugh39 If you are protecting a belief, and indoctrinating people into an ideology, you control the definitions to fit the belief. Pseudo scientists believe in their mind that they are correct and as you know people do a lot of damage in the name of their "good" beliefs not based on anything. When people change already established words to mean what a belief has, then it is a religion. The Etymology of Evolution is only one way towards more complex. Computers evolve. humans don't.

GoodScienceForYou 5 hours ago
@GoodScienceForYou

The theory of evolution is well defined by science. If someone then use a different definition and then claims that it is a definition for the theory of evolution, then that person is either criminally ignorent or a liar. I also suggest that you look up what the word "religion" mean, I suggest you use OED.

According to the theory of evolution, humans (and any other living thing) are constantly evolving. Speciation has been observed soevolution is both a theory and a fact.

Draugh39 3 hours ago
@Draugh39 This idea that creature evolve is the crime. There is ABSOLUTELY no evidence than can't be refuted by other more effective plausibilities that actually fit the evidence. It really is a mythological religious ideology. Anyone who falls for this is called an Evotard, because they will not look at the evidence and only the evidence before making any conclusions. The conclusions only fit the religious belief, but they are false conclusions. Don't be an Evotard! Start looking!

GoodScienceForYou 3 hours ago
@GoodScienceForYou

What a load of cobblers! But let's test you shall we.

What other explainations exist for the evolution of Flavobacterium, Sp. K172 that allows it to consume nylon? What other explainations exists for the evolution of the London Underground mosquito?

You claim they exist now present them.

Draugh39 3 hours ago
@Draugh39 1 - 2 Bacteria is never to be compared with other species. It has its own set of programming to survive no matter what. And it has de-evolved from the archaic species we still see on earth. Bacteria will adapt to eat any digestible form of carbon based matter. They have bacteria that can digest crude oil now. It is ridiculous to use the "synthetic" argument, because there is no synthetic carbon on earth. Like I said I am way ahead of you on this.

GoodScienceForYou 3 hours ago
@GoodScienceForYou

"Bacteria is never to be compared with other species."

Really, why not - it has DNA and reproduce so it agrees with evolution like all other species on the planet.

"Bacteria will adapt to eat any digestible form of carbon based matter."

LOL. you utterly miss the point. Nylon wasn't digestable until after that species evolved.

And as for synthetic. I hardly think you understand what that is. difference between synthetic copper and native?

Draugh39 3 hours ago
@Draugh39 What you call evolved is not. Bacteria has always remained as bacteria. We have living species of ancient bacteria and it was and still is bacteria. The ability of bacteria to adapt has nothing to do with any other species. It has its own set of rules. When you project belief on bacteria and try to project its ability to adapt better than any other creature you are not being honest. It is not your fault that you believe this. It is cultural brainwashing just like any ideology.

GoodScienceForYou 3 hours ago
@Draugh39 London Underground mosquito? The mosquito is a horrible argument because it has been documented at 125,000,000 years and identical in morphology. It is well known in genetics that separation from the group will lead to in ability to breed with the old group. This is not evolution ,but separation and continued de-evolution. Evolustionists will look at a turd on the ground and say it "suggests" evolution. Humans could never breed with even 10 generations back who were still human.

GoodScienceForYou 3 hours ago
@GoodScienceForYou

The London underground mosquito can't interbreed with the parent species. It is thus a new species which have adapted to an environment where the old species couldn't live. It is thus better than the old species in this environment. what you state is bollocks

Draugh39 3 hours ago
@Draugh39 Do you know and is it really any better or stronger? NO! It just adapted to the new environment. Goto GoodScienceForYou Neutral Evolution Forum and read the posting there. Many Evolutionists have been there and some PHD's in genetics who failed to present any foundational evidence for evolution. I only go with the original definition of evolution and not the nonsense one used today.

GoodScienceForYou 3 hours ago
@Draugh39 1 of 2 In all cases there is only a de-evolving, loss of gene expression, and general degradation from fitness for survival. This is why humans are quickly heading for exitnction. If you want to stop this trend of the human genome degrading so rapidly, then you need to stop believing in magical "fixes" that do not appear. The net of genetics is traits are reduced, strength is less, intelligence is less, and much more genetic diseases.

GoodScienceForYou 3 hours ago
@Draugh39 2 of 2 Chimps, Gorillas, orangutan' almost extinct, because of lack of fitness. They simply don't have the genetics to survive with the degraded functions needed to live. They are food, sort of a cannibalistic thing. Chimps, Gorillas, orangutans, macaques all devolved from humans. Their fossil evidence or lack of shows they are much younger in terms of time on earth than humans. The DNA backs this up precisely.

GoodScienceForYou 3 hours ago
@GoodScienceForYou

"The DNA backs this up precisely."

I'm tired of unsupported CGSM from you. Give the reference to the scientific study that shows this. Or admit that you lied.

Draugh39 3 hours ago
@Draugh39 Go look up human, chimp, gorilla, orangutan. All of it. DNA chromosomes fusions, and fossil record on all of them. The oldest upright human is documented at 6.1 million years. When this femur was found it upset Evolutionists so much that they denied it, but they can't the fellow who discovered this has the evidence. And we have modern humans now at 500,000 to 400,000 years found in Israel recently. How many fossils are there on the great primates? Go look. It is easy to find.

GoodScienceForYou 3 hours ago
@GoodScienceForYou

I asked you for a reference. You claim as fact that "Chimps, Gorillas, orangutans, macaques all devolved from humans" and that "The DNA backs this up precisely."

Now give the reference to this study or admit that you lied.

Draugh39 3 hours ago
@Draugh39 The references are all on the GoodScienceForYou Neutral Evolution Forum for you to read.

I keep adding more each day as I find them. They come from all the evidence that you use. There is no such thing as Evolution: "that theory which sees in the history of all things organic and inorganic a development from simplicity to complexity, a gradual advance from a simple or rudimentary condition to one that is more complex and of a higher character."

GoodScienceForYou 3 hours ago
@GoodScienceForYou

What part of "scientific study" did you have problems with? Again give the reference to the study that back up your claim or admit that you lied.

Draugh39 3 hours ago
@Draugh39 I know it is hard to take, but it is from your scientists papers. I have read over 21,000 of them and found the ones on the chimp to be fascinating and OBVIOUS. It is not the end of the world to realize that you were taught wrong. It can only help to make you a better scientist. Beleifs are crap, When people project beliefs on evidence they screw it all up and distort it, hide facts from themselves.

GoodScienceForYou 3 hours ago
@GoodScienceForYou

I'm a scientist and an active researcher with about 60 publications to my name and have access to the worlds peer reviewed journals and quite a few more. So give the reference to the article you claim support this or admit that you lied.

What journal, what author, what year and page number.

Draugh39 3 hours ago
@Draugh39 It is very difficult to past links to articles here. You know that, it is much better for you to go to the GoodScienceForYou Neutral Evolution Forum and look! It is safe there. I make sure of that. I have a tested IQ of 180 and a photographic memory. I read thousands of articles and probably have read yours. I am able to put together data and put all the evidence to show what is really happening. Take a breath and relax. This is an adventure for you to break free of ideology.

GoodScienceForYou 2 hours ago
@GoodScienceForYou

I didn't ask for a link.

I asked for the name of the journal, the name of the authors, the year of publication and the page numbers. This is the standard way any reference is given and as I have access to the journals I can find it based on that. The title of the article is helpful but normally not needed.

With a photographic memory that would be trivial for you to do

So give the reference or admit that you lied.

Draugh39 2 hours ago
@Draugh39 I have referenced well over 20 of them and more. I even put the DNA of the predecessor of the Chicken on there. Don't be an egotistical fool. There is nothing worse that that for a scientist to be. If you want to know then go look. If you don't want to know then keep your head in the sand and all your beliefs in tact. Beliefs destroy credibility. I don't have any beliefs. No religion. I go for the truth. People are stupid. With my IQ I see stupid people everywhere.

GoodScienceForYou 2 hours ago
@Draugh39 Evolution of gene function and regulatory control after whole-genome duplication: Comparative analyses in vertebrates Karin S. Kassahn, 1 Vinh T. Dang, 1 Simon J. Wilkins, 2 Andrew C. Perkins, 2 and Mark A. Ragan 1,3 1 The University of Queensland, Institute for Molecular Bioscience and ARC Centre of Excellence in Bioinformatics, Brisbane, QLD 4072, Australia;
GoodScienceForYou 2 hours ago
@Draugh39 remainder of heading: 2

The University of Queensland, Institute for Molecular Bioscience and Australian Zebrafish Phenomics Facility, Brisbane, QLD

4072, Australia

GoodScienceForYou 2 hours ago
@Draugh39 29+ Evidences for Macroevolution

Part 4:

The Molecular Sequence Evidence

Copyright © 1999-2004 by Douglas Theobald, Ph.D.

GoodScienceForYou 2 hours ago
@Draugh39 I just gave you two. I have the one on the laryngeal nerve as well. 29+ Evidences for Macroevolution

Part 3:

Opportunism and Evolutionary Constraint

Copyright © 1999-2004 by Douglas Theobald, Ph.D.

GoodScienceForYou 2 hours ago
@Draugh39 You can go and get the rest. And read my explanations for my conclusions.

GoodScienceForYou 2 hours ago
@Draugh39 Identification of the Yellow Skin Gene Reveals a Hybrid Origin of the Domestic Chicken. Jonas Eriksson1, Greger Larson1, Ulrika Gunnarsson1, Bertrand Bed'hom2, Michele Tixier-Boichard2, Lina Strömstedt3, Dominic Wright1, Annemieke Jungerius4, Addie Vereijken4, Ettore Randi5, Per Jensen6, Leif Andersson1,3*

GoodScienceForYou 2 hours ago
@Draugh39 second part on the chicken: 1 Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden, 2 INRA, AgroParisTech, UMR1236 Génétique et Diversité Animales, Jouy-en-Josas, France, 3 Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden,

GoodScienceForYou 2 hours ago
@Draugh39 third part on the chicken; 4 Hendrix Genetics, Breeding Research & Technology Centre, Boxmeer, The Netherlands, 5 Istituto Nazionale per la Fauna Selvatica, Laboratorio di Genetica, Ozzano Emilia, Italy, 6 IFM Biology, Linköping University, SE-58183 Linköping, Sweden

GoodScienceForYou 2 hours ago
@Draugh39 I am tired of being told to believe in science by people who don't even use the scientific methods.

I have been a scientists all of my adult life, and I would never get a degree in some ideology that has no evidence to back it. There is no magical processes, nor mystical causes in genetics. There is no magic "random mutations" because random violates the first rule of science, CAUSE and RESULT or Cause and Effect. There is no magic that fixes genomes. PERIOD.

GoodScienceForYou 1 hour ago
@Draugh39 Take your time, deep breath, relax. Stop being angry. I am here to help you learn what is actually shown in evidence. If you only get your information from those who's agenda is to perpetuate that which has been proven wrong and within the last 10 years, then you are not honest with yourself. The DNA, ERV's. Fossils, and just the characteristics of the chimps gorillas, orangutans also fit. There is only degraded genomes with no magical "fixes" or more complexity.

GoodScienceForYou 3 hours ago
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@GoodScienceForYou

I'm not agry at all I'm just tired of being lied to all the time. So now I have called you on it.

Again give the reference to the scientific study that back up your claim or admit that you lied. when you stated that "Chimps, Gorillas, orangutans, macaques all devolved from humans" and that "The DNA backs this up precisely."

If you actually have this information it is trivial to give the reference to it.

Draugh39 3 hours ago
@Draugh39 There is nothing about what I teach that is not verifiable. I have the dictionary with the real meaning of this word. Evolution: "that theory which sees in the history of all things organic and inorganic a development from simplicity to complexity, a gradual advance from a simple or rudimentary condition to one that is more complex and of a higher character." Webster's Encyclopedic Dictionary of the English Language.

GoodScienceForYou 5 hours ago
@GoodScienceForYou

There are many definitions for the word evolution and I quoted the latest edition of Webster in regards to biology - you don't, thus you are dishonest .

However, OED is the premier dictionary of the English language, and it reads.

"Evolution - Biol. The transformation of animals, plants, and other living organisms into different forms by the accumulation of changes over successive generations; the transmutation of species ."

Draugh39 3 hours ago
@Draugh39 If you want to indoctrinate into an ideology, the best place is in the classroom. If you want to control the indoctrination change the definitions to match the belief. They realized that evolution is not towards any form of increased complexity, so they use the definition of genetics to replace it with. However the foundation of this etymology means towards the more complex. Computers evolve, humans don't

GoodScienceForYou 1 hour ago
@Draugh39 Evodelusionists are dishonest, and concoct the story to cause belief. They do this out of the "goodness of their hearts" I am sure of that. but it is all nonsense. There is NO increase in gene expression that would give rise to any belief that humans or any creature is going from simple to more fit and more complex.

There are over 2000 genetic diseases in the human family now, and I know for sure you have at least ten of them that will trigger in your life.

GoodScienceForYou 5 hours ago
@GoodScienceForYou

search. "Observed cases of speciation" in google.

Draugh39 3 hours ago
@Draugh39 I have read all of that. Speciation does not show evolution. There is only de-evolutoin the loss of gene functions at every speciation event. Go look. I am way ahead of on this. The definition of species is such a gray area, and there are species that have been separated by over 2 million years that can still mate and have offspring. In order to show evolution you have to prove that this any of them has 1/ added new gene functions, not found in any of the prior generations.

GoodScienceForYou 3 hours ago
@GoodScienceForYou

"Speciation does not show evolution..."

ROFL!! that is exactly what it shows.

"2 million years that can still mate and have offspring"

Which is exactly what we expect. You said you know something about this, why don't you understand even the most simple parts of evolution then?!

"In order to show evolution you have to prove that this any of them has 1/ added new gene functions, not found in any of the prior generations."

I refer to "speciation" above.

Draugh39 3 hours ago
@Draugh39 Accurate and efficient reconstruction of deep phylogenies from structured RNAs Roman R. Stocsits 1, *, Harald Letsch 1 , Jana Hertel 2, *, Bernhard Misof 3 and Peter F. Stadler 2,4,5,6, Look closely at the DNA ties to the primates, realizing that all of them are much younger than humans an all have diminished human genomes.
GoodScienceForYou 52 minutes ago
@Draugh39 The old world monkey have fusions of the human genomes chromosomes and have 2 million less base pairs. They also carry the ERV markers. This shows a direct genetic lineage from humans as their common ancestor. They are much younger than humans.

How is it possible for humans and chimps to have a magical common ancestor when they are so close genetically and the chimp is way younger as a species on this earth. Chimps are obviously the result of a diminished human genome.

GoodScienceForYou 40 minutes ago
@GoodScienceForYou

You don't even understand what you read!? The ERV shows that we have more insertion points than the apes of these specific types retro viruses. The ERV can't simply disappear which mean that we branched off from them!!! Boy for a person that claims to have an IQ of 180 you do show an utter lack of understanding.

By the way a reference is written as follows: Author, Journal name, year of publication, pages. You don't put the address

Draugh39 16 minutes ago
@Draugh39 Having more insertion points at this time means that we have gained in retro virus, because of our life styles. We are exposed to many more virus infections. You are angry, because you are not ready to get clear of these ideologies of your belief. What you do is based on faith and is not following the real evidence.

Chimps are much younger than humans and there is way to much genetically close for anything else. The others are not much of an issue and they are also all younger.

GoodScienceForYou 11 minutes ago
@GoodScienceForYou

You really don't understand that ERV graph then. If chimps and the other apes "de-evolved" from humans (as you state) it would require that the ERV insertions poofed out of existance. That doesn't happen. It would also require that human cromosome No 2 split up. You really don't know what you talk about. get an education.

Draugh39 2 minutes ago
@Draugh39 By the way, I just cut and pasted the top of the article for you to google much easier. If you put it in the google box that way you can't miss it. Don' t be a jerk. I was impressed with you until your denial methods of what is obvious. I know it goes against your faith and belief, but it IS what is in the evidence. There is never any NET increase in complexity any any genetic lineage as it goes through time. This is shown in DNA.

GoodScienceForYou 7 minutes ago
@Draugh39 "mean that we branched off from them!!" Or they branched off from US, is what follows the evidence. And as time goes on we gathered more. It is pure logic, and is objective logic, not based on any faith or ideas of "evolution". I don't believe in anything that people teach, I find the truth for myself.

GoodScienceForYou 4 minutes ago
@Draugh39 It only works ONE WAY. There's no evidence of any increase in gene function. There are only significant diminished gene expressions shown in DNA. There are over 2000 known genetic illnesses in the human genome. They don't magically fix themselves by any mystical causes. They are permanent and can only be removed by genetic engineering. This is OBVIOUS. and if you can't see it, your education is in the way.

"The only thing that interferes with my learning is my education."A Einstein

GoodScienceForYou

Title: Re: AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Feb 14th, 2011 at 10:40pm
@UnexpectedWonder I realise that there is a lot of confusion about this. This is mainly the result of the US's demonisation of the word "atheist". Atheists in the US oftenly call themselves "agnostic", just so they wouldn't be the target of demonisation. So they just "moderatly" say "there is no proof of god though, so we doubt". What they really mean is "don't be such an idiot believing in fairy tales".

Just realise that (a)gnosticism and (a)theism are NOT mutually exclusive.

ScientificBob 17 hours ago
@UnexpectedWonder Theism deals with belief in a personal god. Gnosticism deals with knowledge. One is a qualifier of the other:

- gnostic theist: I know there is a god.

- agnostic theist: I have faith there is a god

- gnostic athiest: I know there is no god

- agnostic atheist: I don't believe in gods.

See?

ScientificBob 17 hours ago
gnostic theist: I 'know' there is a god(s)

agnostic theist: I think there is a god(s)

gnostic atheist: I 'know' there is no god(s)

agnostic atheist: I think there is no god(s)

So many problems would be avoided if people just knew what these 4 simple categories were.

In my opinion, since we can't "know" either way, we are all either agnostic theists or agnostic atheists -

so it just comes down to whether or not you think a supernatural intelligence that controls morality is logical or not.

leighgridley 16 hours ago
@leighgridley Indeed. I have also always maintained that those who call/describe themselves (directly or indirectly) as being "gnostic theist" or "gnostic atheist" are either intellectually dishonest, delusional or simply lying.

Contrary to popular opinion, atheists can be intellectually dishonest as well. :)

ScientificBob 15 hours ago
@UnexpectedWonder Common ancestry is a fact. The theory explains HOW this happened: through mutation and natural selection. To doubt this is just silly. The evidence for it is completely overwhelming. More factors then JUST natural selection (ie: what lives and reproduces carries on the genes that allowed for it) come into play off course (genetic drift, sexual selection etc) and no doubt in my mind that more will be uncovered.

ScientificBob 17 hours ago
@UnexpectedWonder How come the chimpansee's short term memory out performs us 1000-fold?

Reason: they live in trees and swing from tree to tree. Outstanding short term memory enables them to perfectly remember where every branch is in a split second . This allows for fast travel through trees.

Why do humans have advanced intellect? We left our comfort zone in the jungle. We were a vulnerable social species that were faced by all sorts of threats. Our intelligence offered a way out.

ScientificBob 17 hours ago
@JayMerc75 No scientist is debating evolution theory.

Creatards are spewing nonsense and scientists are correcting them. There is no debate. There is only ignorant people who know NOTHING about biology who need to be educated - and some scientists are attempting to do that. The others are just going about their daily business working withing evolutionary biology, laughing at people like you.

ScientificBob 17 hours ago
@JayMerc75 Again, what we have in common with other animals can be mapped PERFECTLY onto the phylogenetic tree. You can draw this tree INDEPENDENTLY based on geographic spread of species, the fossil record, DNA strings, single genes, anatomy, fysiology,... And it's ALWAYS the SAME tree.

It's a FAMILY TREE. The closer we are related to another species, the more things we have in common in EVERY aspect (geography, DNA, gene sequences, single genes, anatomy, fysiology etc etc).

ScientificBob 17 hours ago
@ScientificBob I was confused by the term "fysiology" until I saw you were from Belgium. The English version is "physiology". Terrific post by the way.

ExtantFrodo 14 hours ago
@ExtantFrodo Ha, thanks :) Yeah, even in dutch I get confused about "f" and "ph". Especially in Belgium, with all the history with the french. We borrow heavily, in language, from french and english. It's "f" and "ph" all over the place in such words and sometimes, both are even correct. lol.

ScientificBob 9 hours ago
@ernesto7012 However, this does NOT change the fact that DNA-wise, we are far more similar to chimps then chimps are to gorilla's. DNA doesn't lie. If people want to claim that we can't use DNA as a comparative standard, then they should also claim that paternal testing can't work. Wich they off course will never do. And that's why these creatards are hypocrits and liars.

ScientificBob 18 hours ago
@entificBob Ah but then again, if you don’t have a genetic sample from the child how can you prove the parents had a child? Without the missing link between Humans and Chimps how can you assert to have proof; you can say comparative DNA suggests to the existence of CHLCA but you can never say that it proves its existence Theories are never certain and Evolution is proof of this and just like the existence of God is rejected by lack of physical proof by logic Evolution should be equally rejected

ernesto7012 10 hours ago
@ernesto7012 That didn't make a lot of sense and it (again) show your lack of comprehension about the subject. First of all, "theory" in science means EXPLANATION. NOT "guess" or "hunch".

Secondly, paternal testing is practical application of the exact same principles. It all boils down to the hereditary and accumulative nature of DNA. This is why the test works. And this is why the genographic project works. And this is how we can measure the level of "relatedness" between 2 organisms.

ScientificBob 9 hours ago
@ernesto7012 Once more, to make sure you get it. DNA is CUMULATIVE. What happens to it in A is traceable in it's offspring's DNA if the event was hereditary. If we map out our DNA compared to ANY OTHER creature, we get an hierarchical tree that corresponds PERFECTLY with the fossil record, comparative anatomy,.. even the geographic spread of species. This is because it is a FAMILY TREE. You can debunk evolution by finding an organism that breaks this tree. You'll get a nobel prize for sure!

ScientificBob 9 hours ago
You know that technology we use for paternity suits? It takes the chromosomes and using a special code selective cutter breaks the chromosome into CHUNKS and we sort the chunks according to size. The result (just by weight of segments) is sufficient to indict for murder.

In human vrs chimp we are looking at the actual text of the DNA base pairs, it's not merely similar in the functional 'useful' regions, it is identical in virtually all the non-coding & broken places as well as ERV locations.

ExtantFrodo 9 hours ago
@ernesto7012 Here's the thing. How do you know Joey has cheated on his school test? If he cheated he probably copied the wrong answers along with the right ones. Getting the right answer is statistically not abnormal, but two people constantly getting the same WRONG answers (ERVs,pseudoggenes,noncoding mutation patterns) indicates cheating(copying) in other words...common descent. Google evolutoin of the primate GULO gene for an excellent example.

ExtantFrodo 9 hours ago
@ExtantFrodo Yes, exactly, the odds of chimps and human not from the same genetic lineage is phenomenal. I put videos on this on my forum. The odds of humans being the chimps "common ancestor" are over 1/.99 meaning that chimps are degraded human genome descendent's. This is also because the oldest upright human is over 6 million years old according to radiometric dating. Chimps are no more than 500 thousand years old.

GoodScienceForYou 9 hours ago
@ExtantFrodo ANSWER Joey has to be caught on the act to positively say that he has cheated other way you are just assuming same goes for the existence of CHLCA base on DNA testing you are just assuming its existence There is your leap of Faith There aren’t any fossils for CHLCA, proto-chimp or proto-gorilla you are just assuming their existence; as a believer I’m not ashamed to say that I walk by Faith but you have to admit you have some of that too

No specimen No test No Proof Simple as That

ernesto7012 8 hours ago
@ernesto7012 Having the same WRONG answers is equivalent to being caught in the act. I will post the statistics next. You will note I only post for up to THREE. I leave it as an exercise for you to figure what the odds are for the HUNDREDS of different species of primate each of which share the broken GULO gene.

ExtantFrodo 8 hours ago
We are talking about the same mutation in the same gene.

The odds of this happening at random in 2 separate organisms with human sized genomes(HSG) is 1 in 3 Billion.

The odds of this happening at random in 3 separate organisms with HSG is 1 in 9 Billion Billion.

The odds of this happening at random in 4 separate organisms with HSG is 1 in 27 Billion Billion Billion.

The odds of this happening in hundreds of different primates due to common ancestor 1:1

ExtantFrodo 8 hours ago
@ExtantFrodo Absolutely, and they all de-evolved from humans and intermixing the breeding with primates.

This is shown in all the evidence, if you look.

How many fossils of Gorilla? Chimp? Orangutan?

Zero, One, One

The orangutan is from 100 thou to 2mil much younger than upright human predecessors. Chimp is 500thou.

But the dating is flawed, of course, because it is based on assumptions that can never be verified.

Even so the theory of human as the common ancestor fits the evidence we do have

GoodScienceForYou 8 hours ago
@ExtantFrodo If you open your eyes, you too will see that all of the evidence points only to humans as the common ancestor of all the apes and continual degradation of the original human genome as we see today.

GoodScienceForYou 8 hours ago
@GoodScienceForYou "If you open your eyes, you too will see that all of the evidence points only to humans as the common ancestor of all the apes"

chimps, gorillas, orangutans, bonoboes, macaques, all descended from humans, but without evolution. You never cease to amaze me.

ExtantFrodo 6 hours ago
@ExtantFrodo Go look at the evidence. It is all there for you to see. Why do you need this magical ape man that has never been seen, and all the evidence points in the opposite direction from any form of evolution as defined.

Evolution: "that theory which sees in the history of all things organic and inorganic a development from simplicity to complexity, a gradual advance from a simple or rudimentary condition to one that is more complex and of a higher character."

GoodScienceForYou 5 hours ago
@GoodScienceForYou Could you explain to me why you think that genetic algorithms being restricted to pseudo-random mutation means that the positive results obtained are invalid?

ExtantFrodo 5 hours ago
@ExtantFrodo Because it is artificial and does not represent reality. Life is not a computer game.

GoodScienceForYou 5 hours ago
@GoodScienceForYou In as much as it is a model of reality, I ask why can you not force evolution to not occur even as god of the simulation? Why does it have to occur no matter what you try to do? Why does it have to occur even in theory when you apply all mathematical rigor to it?

ExtantFrodo 5 hours ago
@ExtantFrodo "Sexual intercourse plays a major role in Bonobo society observed in captivity, being used as what some scientists perceive as a greeting, a means of conflict resolution, and post-conflict reconciliation. Bonobos are the only non-human animal to have been observed engaging in all of the following sexual activities: face-to-face genital sex, tongue kissing, and oral sex". There are a lot of Human characteristics in Chimp family.

GoodScienceForYou 5 hours ago
@ExtantFrodo 2,588,000 to 12,000 years Is where the macaques fit, and they have reduced chromosomes from Human and are definitely and offshoot of the chimp at 500,000 years. The timeline fits just fine for degradation from Human on down to this time. The chromosomes show alignment with humans and some more fusions.

Chomosomes don't un-fuse. Once they are fused the don't evolve and separate.

GoodScienceForYou 3 hours ago
There are almost 2 million less base pairs in the macaques as well. This means de-evolution for sure with all the other evidence.

GoodScienceForYou 3 hours ago
@ExtantFrodo Are Scientific Truths based on odds? Because I thought those where based on first hand experimentation Would you believe in the existence of God if I tell you that there is a 100% possibility that God exists and that I am the physical proof for that.

Other than my words what would you ask of me to accept the existence of God? Wouldn’t it be a first hand experience? Why am I wrong by asking the same? Evolution is not a proven fact; too many missing links just keep it a Theory

ernesto7012 7 hours ago
@ernesto7012 Google "Practical applications of evolution". That shows just how much evolutionary theory has moved from HYPOTHESIS to THEORY. A BIG distinction here that you seem not to realize is that a theory in science is something that has been proven time and again. The theory of gravity, the theory of relativity, the theory of evolution. Also, watch this vid:

watch?v=dK3O6KYPmEw

This shows a prediction evolutionary theory made that we discovered was true. Against the odds.

ProblemHonorStudent 7 hours ago
@ProblemHonorStudent Is it a proven fact that CHLCA ever existed? NO it is a hypothesis a simple supposition within the Evolution Theory What I’m saying is that you can’t claim to have the truth when you have no means to prove it The scientists can play with theories but my Faith does not depend in the results of those theories and if you are going to blame me because I have faith; wouldn’t it be better to discern your own faith?

ernesto7012 6 hours ago
@ernesto7012 I don't blame you for your faith, under one condition; You don't apply your faith-based beliefs to politics or science. In other words, let the pastors do the preaching, let the teachers do the teaching, and let the scientists discern truth from fiction, based on the evidence. While every single piece of the puzzle isn't in, that's no reason to discount the theory. We don't completely understand atoms, but we have a pretty good handle on them. Practical applications, like I said.

ProblemHonorStudent 6 hours ago
@ernesto7012 Evolution withstands the obliteration test. Obliterate all writings and memory of evolution, it can be reformed entirely from evidence. Obliterate all writings and memory of a religion, it's gone forever. It can't be reformed from evidence.

ExtantFrodo 5 hours ago
@ExtantFrodo Actually the evidence is against evolution. The ideological belief is not founded on the evidence. When it started there was no DNA, and not many fossils. It was an idea and that idea took hold in people's minds and people project belief on the world all the time. There is no evolution, only adaptation, and de-evolution or downgrading of all species. There is no evidence for added complexity.

GoodScienceForYou 5 hours ago
@ExtantFrodo At the time this "theory" was presented there was no evidence to give rise to this. It came from an archaic belief system. PERIOD. Then this guy had this idea that magical causes were in nature. Just like all religions it took hold and people want to believe in this. It is not self generating. DNA pretty much destroys it.

GoodScienceForYou 5 hours ago
@GoodScienceForYou Darwin spent decades going over his collected data. To say there was no evidence at the time is a lie.

ExtantFrodo 5 hours ago
@Frodo Let’s say someone obliterate all writings and memory from both science and religion from the world I propose that history will repeat itself humans will look for a higher power then some will experience this Higher Power and some don’t dividing the human race again between those who believe and those who don’t believe, believers will say My Spirit tells me so The Unbelievers will say We are animals, let us live our only lives as we want, besides where do you get this thing called Spirit?

ernesto7012 4 hours ago
@ernesto7012 "Are Scientific Truths based on odds?"

When the odds of something occurring at random are billions and billions and billions and billions and billions and billions to one against and the odds of it occurring due to some other explanation are one to one for it then yes to not call it true is just plain stupid. Especially when it's also parsimonious with all the other evidence.

ExtantFrodo 5 hours ago
@ExtantFrodo The brokne GULO gene is ovbvious from the human ancestor. It also fits perfectly.

GoodScienceForYou 8 hours ago
@ExtantFrodo The assumption is that there is some magical ape man that these creatures humans and primates came from. The evidence of ONLY continual NET degradation is against this idea of any improvement from the crude, primitive to the advanced and more intelligent etc. So, the great primates can only have de-evolved from humans with superior genetic structures, superior brain capacity, superior abilities to adapt and survive. Most of those are gone now. We are very weak physically compared.

GoodScienceForYou 8 hours ago
@ernesto7012 There is no "agenda". There is no "special" evolution. Yes, we APPEAR to have less in common with chimps then chimps do with gorilla's, yes. But that's just looks. And to be honest, it's not THAT big a difference: bigger brain (as good as ALL changes to our head is a result of this), we walk upright, we lost our fur (and our skin softened). As far as looks goes, that's about it.

ScientificBob 18 hours ago
Just wondering why no one has figured this out: for millions of years, humans have been here, but still have no idea or clue how the human body fully works or functions. yet we are slowly trying to "create" robotic simulations of humans. So does that not somehow clue in that the human body is in itself a super organic computer? which can never be replicated. and also with millions of species being different unique organic computers. all supposedly started from a single cell bacteria.

zeineguy 18 hours ago
« for millions of years, humans have been here »

Bit less. Current best estimate is 300.000 years tops. Agriculte has only existed for about 11.000 years. We developed writing less than 8000 years ago. And that's when things really started happening.

XGralgrathor 13 hours ago
@XGralgrathor current best extimate.. wow nice of you to bring the facts. and how did you come to this conclusion? honestly why dont you just not comment or even better, just say WE DONT f**kING KNOW!!! cause that is the correct answer. when was the last catastrophic event on earth? it is at that point that humans came to being on this planet.

zeineguy 6 hours ago
« So does that not somehow clue in that the human body is in itself a super organic computer? »

No, it doesn't. It shows that humans are slowly learning to understand and mimic nature.

XGralgrathor 13 hours ago
@XGralgrathor lmfao

zeineguy 6 hours ago
amazing video. So we can find dinosaur fossils and bones, millions of years ago.. but we still havent found that "missing" link. somewhere that it mutated twice with one side going to humans and the other going to apes. Seriously, Dawkins just picked a side less popular and using it to make a living. Has to keep up the shill to put out more books for the trolls. But even he has NO real inclination as to where we came from. POOF!! its magic!!

zeineguy 18 hours ago
Enlightened Theologians know that evolution is true due to the fact that the evidence is so overwhelming. If only more religious people were somewhat enlightened.........

MVT44 21 hours ago
This guy is a joke!! He always has a made up ready answer to try to confuse you. This freak insults my intelligence and you wonder why people act like animals because we are taught that we came from them. lol

mindsprain 22 hours ago
@mindsprain "act like animals" ... you mean sharing loving raising our young helping eachother survive difficult times.. those sort of things animals do?

ExtantFrodo 22 hours ago
Tsk, tsk dawkins!, where is your evidence???, 6million years ago my arse!, just more assumptions and speculation!, what made us suddently barnch off???, evolution raises more questions than answers!.

Aheadstix85 23 hours ago
The Corporations want fodder for the corporations that do not have "ethical" issues that would stop them from getting as much money as possible. Using science to promote atheism is good for corporations. You do not want a CEO with a conscience. Understand.? Corporations own the Ivy League universities in US and Europe with endowments. One has a $3 billion endowment in excess of anything they can spend.

GoodScienceForYou 1 day ago
Ah, atheism. The perfect position to take when you are a rebel who wants an excuse to commit crimes.

Thankfully, the righteous will always safeguard society against these types of evil.

EspnNBAGeneral 1 day ago
@EspnNBAGeneral The Corporations want fodder for the corporations that do not have "ethical" issues that would stop them from getting as much money as possible. Using science to promote atheism is good for corporations. You do not want a CEO with a conscience. Understand.? Corporations own the Ivy League universities in US and Europe with endowments. One has a $3 billion endowment in excess of anything they can spend.

GoodScienceForYou 1 day ago
Stephen Baldwin making comments on science is like my cat analyzing motorcycle technology.

donfishmaster 1 day ago
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UnHolyBabble 1 day ago
I like how this guy has no more than a wall chart for evidence to his claims. What a fool

Reisaei 1 day ago
@Reisaei and a few hundred years of research.

GutlessNut 1 day ago
@Reisaei Are you f**king serious? You need more than a chart to realize you look sort of like an ape, because we have common ancestors? If you can't understand that, then stop trying. You're clearly lost forever, guy.

beatonm198 1 day ago
@beatonm198 "because we have common ancestors?" The common ancestor is human. This is in all the evidence. Goto GoodScienceForYou Neutral Evolution Forum. I have decoded all the evidence for you there.

Evolution is a religion with mystical common ancestors that they never seem to find. This is because they are still trying to hold on to this ideology for over 150 years of constant evidence against it.

GoodScienceForYou 1 day ago
The fossils are dated by the rocks they are found in the rocks are dated by the fossils found in them there are no transitional forms found in the fossil record. Jesus loves everyone and someday we all have to face him .

primetimebuckeye 1 day ago
@primetimebuckeye wrong. the rocks are date by radio isotope ratios of parent/daughter content.

if you've many hourglasses (say a 1hr, a 2hr, a 3hr & a 9hr) and you test a sample and find

the 1hourglass is empty (more than 1hr)

the 2hourglass is 3/4ths empty (1.5 hrs)

the 3hourglass is 1/2 empty (1.5 hrs)

the 9hourglass is 1/6th empty (1.5 hrs)

And You obtain similar corresponding results with the vast majority of the samples you take (and showing greater time with deeper samples).

Conclusion?

ExtantFrodo 1 day ago
@ExtantFrodo "Conclusion?" It is based on primitive assumptions and beliefs. They don't even know what "time" is.

GoodScienceForYou 22 hours ago
@GoodScienceForYou Primitive assumptions like "whoa, when I obtain the same ratios for all these element no matter where i sample on the earth and it fits this mathematical model of radioactive decay very very well, I should just throw out any notion that it's reliable or significant."

time for you to go to bed bonzo.

ExtantFrodo 22 hours ago
@ExtantFrodo Yes Primitive assumptions are not science. They do not have enough data to use this radiometric dating. There is no way to verify any of it with historical data beyond 10,000 years. That is like trying to light a 47 mile road in pitch black with a flashlight that shines for 6 inches. How can you fall for a bunch of retarded assumptions like that?

GoodScienceForYou 19 hours ago
@GoodScienceForYou Give a set of samples to different labs and they will put them in the same order. The exact same order they were in the undisturbed earth. By your failure of understanding that should be impossible. So how do they do it?

ExtantFrodo 14 hours ago
@primetimebuckeye Evolution is constantly in motion, therefore ALL forms found are transitional. Fossils are rocks themselves, generally created by the addition of minerals to bone over time which permeates them and allows for their ability to last so long within the rock. Know what you're talking about before you refute plain and obvious evidence against your highly held beliefs.

beatonm198 1 day ago
@beatonm198 They are all transitional toward de-evolution. All of the evidence on ALL creatures shows only a one way path of degrading and gene loss. This is in all the DNA of all species. Why don't you know this?

GoodScienceForYou 1 day ago
@GoodScienceForYou Correct, the C

Title: Re: AlanCFAs idea of evidence for evolution Transitions
Post by GoodScienceForYou on Feb 28th, 2011 at 11:10pm
This is the predecessor of the mouse, and rat, supposedly.

It is far more complex, much stronger bone structure and far more fit than present day rat or mouse.

Description      
Deutsch: Masillamys sp. Archivnummer: SMF ME 11295 (A–C); Ort der Verwahrung: Senckenberg Forschungsinstitut und Naturmuseum, Abteilung Messelforschung, Frankfurt am Main, Germany. Alter: ca. 47 Mio. Jahre. Fundort: UNESCO Weltnaturerbe Grube Messel bei Darmstadt. Fund der Senckenberg-Grabung im September 2007.
Date      
19 March 2009
Source      
Own work

Author      
Gerbil
800px-Masillamys_Senckenberg_2007-01Rodent.JPG (130 KB | 401 )

Title: Re: AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Feb 28th, 2011 at 11:13pm
This is the predicessor of the Beaver.  Much stronger, larger and more fit.

Giant beaver (Castoroides ohioensis) skeleton on display at the Field Museum of Natural History in Chicago, Illinois. Taken August 2006 by my girlfriend, C. Horwitz, and uploaded with permission under the GFDL. —Steven G. Johnson
800px-Giant-beaver-fieldmuseum.jpg (69 KB | 406 )

Title: Re: AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Feb 28th, 2011 at 11:20pm
Another of the rodent family.  Far more able, far stronger and much more fit for survival. 

Ceratogaulus hatcheri skeleton, Museum of Natural History Washington, D.C. USA.

Date      
1 January 1980, 00:14

Source      
Epigaulus hatcheri

Author      
Ryan Somma
Ceratogaulus_hatcheri_NMNH.jpg (180 KB | 368 )

Title: Re: AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Feb 28th, 2011 at 11:28pm
Giant prehistoric rats. They keep getting smaller and less complex.

http://www.repository.naturalis.nl/document/150080THREE

Title: Re: AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Feb 28th, 2011 at 11:36pm
This is an ancient Rat that is still living today in South America.  It is still smaller than its predecessor and less complex.

English: Photo of a Capybara, formatted (and sized) as a widescreen computer desktop background.
Date      
2007-09-16 (original upload date)

Source      
Transfered from en.wikipedia

Author      
Original uploader was VigilancePrime at en.wikipedia

Permission
(Reusing this file)      
CC-BY-3.0; FAL; Released under the GNU Free Documentation License.
800px-Capybara_Hattiesburg_Zoo__70909b-42__2560x1600.jpg (150 KB | 442 )

Title: Re: AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Feb 28th, 2011 at 11:43pm
Another prehistoric Rat creature. 

Early Eocene, 50 million years old, Ischyromys oweni

Date      
10 October 2008, 10:39

Source      
Ischyrotomys oweni

Uploaded by FunkMonk
Author      
Claire H. from New York City, USA
800px-Ischyromys_oweni.jpg (97 KB | 451 )

Title: Re: AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Feb 28th, 2011 at 11:54pm
Why is it that all the predicessors of the rat are larger and more fit have more features, more flexible "hands" and "feet" than the pathetic rats of today? HMM? Could it be de-evolution?


http://www.newscientist.com/article/dn13188-onetonne-rodent-discovered-in-south-america.html

Title: Re: AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Mar 1st, 2011 at 12:05am
There is even a rodent family tree over there.  Even though I think it is most likely incorrect and based on assumptions,  it STILL shows de-evolution to the far degraded modern rats.

http://news.nationalgeographic.com/news/2003/09/photogalleries/giantrodent/

Title: Re: AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Mar 1st, 2011 at 12:18am
I rest my case.  Rats are way de-evolved from any of the ancient genetic lineages.

Rat in a flowerbox in New York City.

Date      
April 2008
Source      
David Shankbone

Author      
David Shankbone

Permission
(Reusing this file)      
Attribution required
800px-NYC_Rat_in_a_Flowerbox_by_David_Shankbone.jpg (131 KB | 386 )

Title: Re: AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Mar 2nd, 2011 at 3:32pm
Here are a few of the gene loss or gene expression loss articles:

MicroRNA-183 family expression in hair cell development and requirement of microRNAs for hair cell maintenance and survival.
Weston MD, Pierce ML, Jensen-Smith HC, Fritzsch B, Rocha-Sanchez S, Beisel KW, Soukup GA.
Dev Dyn. 2011 Feb 28. doi: 10.1002/dvdy.22591. [Epub ahead of print]
PMID: 21360794 [PubMed - as supplied by publisher]
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2.
Rdh10 mutants deficient in limb field retinoic acid signaling exhibit normal limb patterning but display interdigital webbing.
Cunningham TJ, Chatzi C, Sandell LL, Trainor PA, Duester G.
Dev Dyn. 2011 Feb 28. doi: 10.1002/dvdy.22583. [Epub ahead of print]
PMID: 21360789 [PubMed - as supplied by publisher]
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3.
Diurnal dynamics of S-phase entry of germ cells in the secondary testis of the bambooleaf wrasse (Pseudolabrus sieboldi).
Kitano H, Irie S, Yamaguchi A, Matsuyama M.
J Exp Zool A Ecol Genet Physiol. 2011 Feb 25. doi: 10.1002/jez.669. [Epub ahead of print]
PMID: 21360685 [PubMed - as supplied by publisher]
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4.
hZIP1 zinc transporter down-regulation in prostate cancer involves the overexpression of ras responsive element binding protein-1 (RREB-1).
Zou J, Milon BC, Desouki MM, Costello LC, Franklin RB.
Prostate. 2011 Feb 25. doi: 10.1002/pros.21368. [Epub ahead of print]
PMID: 21360563 [PubMed - as supplied by publisher]
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5.
Microarray hybridization for assessment of the genetic stability of chimeric west nile/dengue 4 virus.
Laassri M, Bidzhieva B, Speicher J, Pletnev AG, Chumakov K.
J Med Virol. 2011 Feb 25. doi: 10.1002/jmv.22033. [Epub ahead of print]
PMID: 21360544 [PubMed - as supplied by publisher]
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6.
Efficacy and safety of anakinra therapy in pediatric and adult patients with the autoinflammatory Muckle-Wells syndrome.
Kuemmerle-Deschner JB, Tyrrell PN, Koetter I, Wittkowski H, Bialkowski A, Tzaribachev N, Lohse P, Koitchev A, Deuter C, Foell D, Benseler SM.
Arthritis Rheum. 2011 Mar;63(3):840-9. doi: 10.1002/art.30149.
PMID: 21360513 [PubMed - in process]
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7.
Arrhythmogenic right ventricular cardiomyopathy/dysplasia: a review and update.
Azaouagh A, Churzidse S, Konorza T, Erbel R.
Clin Res Cardiol. 2011 Mar 1. [Epub ahead of print]
PMID: 21360243 [PubMed - as supplied by publisher]
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8.
Mutation deep within an intron of MSH2 causes Lynch syndrome.
Clendenning M, Buchanan DD, Walsh MD, Nagler B, Rosty C, Thompson B, Spurdle AB, Hopper JL, Jenkins MA, Young JP.
Fam Cancer. 2011 Mar 1. [Epub ahead of print]
PMID: 21360204 [PubMed - as supplied by publisher]
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9.
Detection of APC Gene Deletions in Colorectal Malignancies Using Quantitative PCR in a Chinese Population.
Fang Z, Xiong Y, Li J, Liu L, Li M, Zhang W, Shi L, Wan J.
Pathol Oncol Res. 2011 Feb 26. [Epub ahead of print]
PMID: 21359685 [PubMed - as supplied by publisher]
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10.
Transgene excision in pollen using a codon optimized serine resolvase CinH-RS2 site-specific recombination system.
Moon HS, Abercrombie LL, Eda S, Blanvillain R, Thomson JG, Ow DW, Stewart CN Jr.
Plant Mol Biol. 2011 Feb 26. [Epub ahead of print]
PMID: 21359553 [PubMed - as supplied by publisher]
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11.
Evidence for neuroinflammatory and microglial changes in the cerebral response to sleep loss.
Wisor JP, Schmidt MA, Clegern WC.
Sleep. 2011 Mar 1;34(3):261-72.
PMID: 21358843 [PubMed - in process]
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12.
von Hippel-Lindau protein promotes Skp2 destabilization on DNA damage.
Roe JS, Kim HR, Hwang IY, Cho EJ, Youn HD.
Oncogene. 2011 Feb 28. [Epub ahead of print]
PMID: 21358672 [PubMed - as supplied by publisher]
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13.
Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43.
Polymenidou M, Lagier-Tourenne C, Hutt KR, Huelga SC, Moran J, Liang TY, Ling SC, Sun E, Wancewicz E, Mazur C, Kordasiewicz H, Sedaghat Y, Donohue JP, Shiue L, Bennett CF, Yeo GW, Cleveland DW.
Nat Neurosci. 2011 Feb 27. [Epub ahead of print]
PMID: 21358643 [PubMed - as supplied by publisher]
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14.
Multiple self-healing squamous epithelioma is caused by a disease-specific spectrum of mutations in TGFBR1.
Goudie DR, D'Alessandro M, Merriman B, Lee H, Szeverényi I, Avery S, O'Connor BD, Nelson SF, Coats SE, Stewart A, Christie L, Pichert G, Friedel J, Hayes I, Burrows N, Whittaker S, Gerdes AM, Broesby-Olsen S, Ferguson-Smith MA, Verma C, Lunny DP, Reversade B, Lane EB.
Nat Genet. 2011 Feb 27. [Epub ahead of print]
PMID: 21358634 [PubMed - as supplied by publisher]
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15.
Otosclerosis.
Ealy M, Smith RJ.
Adv Otorhinolaryngol. 2011;70:122-9. Epub 2011 Feb 24.
PMID: 21358194 [PubMed - in process]
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16.
Neurofibromatosis type 2.
Evans GR, Lloyd SK, Ramsden RT.
Adv Otorhinolaryngol. 2011;70:91-8. Epub 2011 Feb 24.
PMID: 21358190 [PubMed - in process]
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17.
Multiple endocrine neoplasia: types 1 and 2.
Marsh DJ, Gimm O.
Adv Otorhinolaryngol. 2011;70:84-90. Epub 2011 Feb 24.
PMID: 21358189 [PubMed - in process]
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18.
Genetic Disorders with both Hearing Loss and Cardiovascular Abnormalities.
Belmont JW, Craigen W, Martinez H, Jefferies JL.
Adv Otorhinolaryngol. 2011;70:66-74. Epub 2011 Feb 24.
PMID: 21358187 [PubMed - in process]
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19.
Usher syndrome: hearing loss with vision loss.
Friedman TB, Schultz JM, Ahmed ZM, Tsilou ET, Brewer CC.
Adv Otorhinolaryngol. 2011;70:56-65. Epub 2011 Feb 24.
PMID: 21358186 [PubMed - in process]
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20.
Nonsyndromic hereditary hearing loss.
Alford RL.
Adv Otorhinolaryngol. 2011;70:37-42. Epub 2011 Feb 24.
PMID: 21358183 [PubMed - in process]
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Association of BMI with the Beta3 Adrenergic Receptor Gene Mutation: A Meta-Analysis.
Kurokawa N.
Nippon Eiseigaku Zasshi. 2011 Jan;66(1):42-6.
PMID: 21358132 [PubMed - in process]
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22.
[Encounter of cancer cells with bone. The Significance of Cancer Stem Cells and Epithelial-Mesenchymal Transition in Tumor Invasion and Metastasis.]
Yoshida GJ, Saya H.
Clin Calcium. 2011;21(3):411-417. Japanese.
PMID: 21358063 [PubMed - as supplied by publisher]
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23.
Kindlin-3-mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption.
Schmidt S, Nakchbandi I, Ruppert R, Kawelke N, Hess MW, Pfaller K, Jurdic P, Fässler R, Moser M.
J Cell Biol. 2011 Feb 28. [Epub ahead of print]
PMID: 21357746 [PubMed - as supplied by publisher]
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24.
CHANGES IN CROSS BRIDGE CYLING UNDERLIE MUSCLE WEAKNESS IN PATIENTS WITH TROPOMYOSIN 3-BASED MYOPATHY.
Ottenheijm CA, Lawlor MW, Stienen GJ, Granzier H, Beggs AH.
Hum Mol Genet. 2011 Feb 28. [Epub ahead of print]
PMID: 21357678 [PubMed - as supplied by publisher]
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25.
Autoregulation of convergent RNAi genes in fission yeast.
Gullerova M, Moazed D, Proudfoot NJ.
Genes Dev. 2011 Feb 28. [Epub ahead of print]
PMID: 21357674 [PubMed - as supplied by publisher]
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26.
Subnuclear segregation of genes and core promoter factors in myogenesis.
Yao J, Fetter RD, Hu P, Betzig E, Tjian R.
Genes Dev. 2011 Feb 28. [Epub ahead of print]
PMID: 21357673 [PubMed - as supplied by publisher]
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27.
Elimination of a group II intron from a plastid gene causes a mutant phenotype.
Petersen K, Schöttler MA, Karcher D, Thiele W, Bock R.
Nucleic Acids Res. 2011 Feb 26. [Epub ahead of print]
PMID: 21357608 [PubMed - as supplied by publisher]
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28.
Testing the Role of P2X7 Receptors in the Development of Type 1 Diabetes in Nonobese Diabetic Mice.
Chen YG, Scheuplein F, Driver JP, Hewes AA, Reifsnyder PC, Leiter EH, Serreze DV.
J Immunol. 2011 Feb 25. [Epub ahead of print]
PMID: 21357538 [PubMed - as supplied by publisher]
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29.
Rapamycin inhibits hydrogen peroxide-induced loss of vascular contractility.
Gao G, Li JJ, Li Y, Li D, Wang Y, Wang L, Tang XD, Walsh MP, Gui Y, Zheng XL.
Am J Physiol Heart Circ Physiol. 2011 Feb 25. [Epub ahead of print]
PMID: 21357511 [PubMed - as supplied by publisher]
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30.
Aberrant expression in multiple components of the transforming growth factor-β1-induced Smad signaling pathway during 7,12-dimethylbenz[a]anthracene-induced hamster buccal-pouch squamous-cell carcinogenesis.
Chen YK, Yang SH, Huang AH, Hsue SS, Lin LM.
Oral Oncol. 2011 Feb 26. [Epub ahead of print]
PMID: 21356605 [PubMed - as supplied by publisher]
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31.
Identification of two novel missense WFS1 mutations, H696Y and R703H, in patients with non-syndromic low-frequency sensorineural hearing loss.
Sun Y, Cheng J, Lu Y, Li J, Lu Y, Jin Z, Dai P, Wang R, Yuan H.
J Genet Genomics. 2011 Feb;38(2):71-6. Epub 2011 Feb 23.
PMID: 21356526 [PubMed - in process]
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32.
Heat Shock Protein 70 (HSP70) Is Critical for the Photoreceptor Stress Response after Retinal Detachment via Modulating Anti-Apoptotic Akt Kinase.
Kayama M, Nakazawa T, Thanos A, Morizane Y, Murakami Y, Theodoropoulou S, Abe T, Vavvas D, Miller JW.
Am J Pathol. 2011 Mar;178(3):1080-91.
PMID: 21356360 [PubMed - in process]
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33.
Loss of endogenous bone morphogenetic protein-6 aggravates renal fibrosis.
Dendooven A, van Oostrom O, van der Giezen DM, Willem Leeuwis J, Snijckers C, Joles JA, Robertson EJ, Verhaar MC, Nguyen TQ, Goldschmeding R.
Am J Pathol. 2011 Mar;178(3):1069-79.
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34.
Kindlin-1 and -2 have overlapping functions in epithelial cells implications for phenotype modification.
He Y, Esser P, Heinemann A, Bruckner-Tuderman L, Has C.
Am J Pathol. 2011 Mar;178(3):975-82.
PMID: 21356350 [PubMed - in process]
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35.
Evaluation of a multi-endpoint assay in rats, combining the bone-marrow micronucleus test, the comet assay and the flow-cytometric peripheral blood micronucleus test.
Bowen DE, Whitwell JH, Lillford L, Henderson D, Kidd D, Garry SM, Pearce G, Beevers C, Kirkland DJ.
Mutat Res. 2011 Feb 25. [Epub ahead of print]
PMID: 21356328 [PubMed - as supplied by publisher]
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36.
From molecule to man: integrating molecular biology with whole organ physiology in studying respiratory disease.
Königshoff M, Uhl F, Gosens R.
Pulm Pharmacol Ther. 2011 Feb 25. [Epub ahead of print]
PMID: 21356323 [PubMed - as supplied by publisher]
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37.
Implementation of high resolution single nucleotide polymorphism array analysis as a clinical test for patients with hematologic malignancies.
Dougherty MJ, Wilmoth DM, Tooke LS, Shaikh TH, Gai X, Hakonarson H, Biegel JA.
Cancer Genet. 2011 Jan;204(1):26-38.
PMID: 21356189 [PubMed - in process]
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38.
Transcriptional impact of organophosphate and metal mixtures on olfaction: Copper dominates the chlorpyrifos-induced response in adult zebrafish.
Tilton FA, Tilton SC, Bammler TK, Beyer RP, Stapleton PL, Scholz NL, Gallagher EP.
Aquat Toxicol. 2011 Feb 2;102(3-4):205-215. [Epub ahead of print]
PMID: 21356183 [PubMed - as supplied by publisher]
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39.
Haploinsufficiency and the sex chromosomes from yeasts to humans.
de Clare M, Pir P, Oliver SG.
BMC Biol. 2011 Feb 28;9(1):15. [Epub ahead of print]
PMID: 21356089 [PubMed - as supplied by publisher]
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40.
Toll-like Receptor 4 (TLR4) expression in human and murine pancreatic beta-cells affects cell viability and insulin homeostasis.
Garay-Malpartida HM, Mourao RF, Mantovani M, Santos IA, Sogayar MC, Goldberg AC.
BMC Immunol. 2011 Feb 28;12(1):18. [Epub ahead of print]
PMID: 21356084 [PubMed - as supplied by publisher]
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Downregulation of the B-cell receptor signaling component CD79b in plasma cell myeloma: A possible post transcriptional regulation.
Huang X, Takata K, Sato Y, Tanaka T, Ichimura K, Tamura M, Oka T, Yoshino T.
Pathol Int. 2011 Mar;61(3):122-9. doi: 10.1111/j.1440-1827.2010.02634.x. Epub 2011 Jan 11.
PMID: 21355953 [PubMed - in process]
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42.
Apoptin Gene Transfer via Modified Wheat Histone H4 Facilitates Apoptosis of Human Ovarian Cancer Cells.
Wang C, Zhang Y.
Cancer Biother Radiopharm. 2011 Feb;26(1):121-6.
PMID: 21355783 [PubMed - in process]
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43.
Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice.
Finberg KE, Whittlesey RL, Andrews NC.
Blood. 2011 Feb 25. [Epub ahead of print]
PMID: 21355094 [PubMed - as supplied by publisher]
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44.
MSUT2 is a determinant of susceptibility to tau neurotoxicity.
Guthrie CR, Greenup L, Leverenz JB, Kraemer BC.
Hum Mol Genet. 2011 Feb 25. [Epub ahead of print]
PMID: 21355046 [PubMed - as supplied by publisher]
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45.
A voxel-based morphometry study of grey matter loss in fragile X-associated tremor/ataxia syndrome.
Hashimoto R, Javan AK, Tassone F, Hagerman RJ, Rivera SM.
Brain. 2011 Mar;134(Pt 3):863-78.
PMID: 21354978 [PubMed - in process]
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46.
Functional YFP-tagging of the essential GDP-mannose transporter reveals an important role for the secretion related small GTPase SrgC protein in maintenance of Golgi bodies in Aspergillus niger.
Carvalho ND, Arentshorst M, Weenink XO, Punt PJ, van den Hondel CA, Ram AF.
Fungal Biol. 2011 Mar;115(3):253-64. Epub 2010 Dec 29.
PMID: 21354532 [PubMed - in process]
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47.
Evolutionary analysis of Glycosyl Hydrolase Family 28 (GH28) suggests lineage-specific expansions in Necrotrophic Fungal Pathogens.
Sprockett DD, Piontkivska H, Blackwood CB.
Gene. 2011 Feb 24. [Epub ahead of print]
PMID: 21354463 [PubMed - as supplied by publisher]
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48.
Mechano Growth Factor E peptide (MGF-E), derived from an isoform of IGF-1, activates human muscle progenitor cells and induces an increase in their fusion potential at different ages.
Kandalla PK, Goldspink G, Butler-Browne G, Mouly V.
Mech Ageing Dev. 2011 Feb 24. [Epub ahead of print]
PMID: 21354439 [PubMed - as supplied by publisher]
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49.
PXR Prevents Cholesterol Gallstone Disease by Regulating Biosynthesis and Transport of Bile Salts.
He J, Nishida S, Xu M, Makishima M, Xie W.
Gastroenterology. 2011 Feb 23. [Epub ahead of print]
PMID: 21354151 [PubMed - as supplied by publisher]
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50.
Axotomy-induced retinal ganglion cell death in adult mice: quantitative and topographic time course analyses.
Galindo-Romero C, Avilés-Trigueros M, Jiménez-López M, Valiente-Soriano FJ, Salinas-Navarro M, Nadal-Nicolás F, Villegas-Pérez MP, Vidal-Sanz M, Agudo-Barriuso M.
Exp Eye Res. 2011 Feb 23. [Epub ahead of print]
PMID: 21354138 [PubMed - as supplied by publisher]
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51.
Identification and evaluation of soft coral diterpenes as inhibitors of HIF-2α induced gene expression.
Grkovic T, Whitson EL, Rabe DC, Gardella RS, Bottaro DP, Linehan WM, McMahon JB, Gustafson KR, McKee TC.
Bioorg Med Chem Lett. 2011 Feb 23. [Epub ahead of print]
PMID: 21353547 [PubMed - as supplied by publisher]
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52.
Imipenem heteroresistance induced by imipenem in multidrug-resistant Acinetobacter baumannii: mechanism and clinical implications.
Lee HY, Chen CL, Wang SB, Su LH, Chen SH, Liu SY, Wu TL, Lin TY, Chiu CH.
Int J Antimicrob Agents. 2011 Feb 24. [Epub ahead of print]
PMID: 21353490 [PubMed - as supplied by publisher]
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53.
Immortalisation of Normal Human Urothelial Cells Compromises Differentiation Capacity.
Georgopoulos NT, Kirkwood LA, Varley CL, Maclaine NJ, Aziz N, Southgate J.
Eur Urol. 2011 Feb 21. [Epub ahead of print]
PMID: 21353380 [PubMed - as supplied by publisher]
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54.
Notch signaling regulates remodeling and vessel diameter in the extraembryonic yolk sac.
Copeland JN, Feng Y, Neradugomma NK, Fields PE, Vivian JL.
BMC Dev Biol. 2011 Feb 25;11(1):12. [Epub ahead of print]
PMID: 21352545 [PubMed - as supplied by publisher]
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55.
Polymorphic CAG repeat numbers in the androgen receptor gene of female pattern hair loss patients.
Yamazaki M, Sato A, Toyoshima KE, Kojima Y, Okada T, Ishii Y, Kurata S, Yoshizato K, Tsuboi R.
J Dermatol. 2010 Nov 2. doi: 10.1111/j.1346-8138.2010.01060.x. [Epub ahead of print]
PMID: 21352305 [PubMed - as supplied by publisher]
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56.
Loss of Wnt-5α is associated with an invasive phenotype of extramammary Paget's disease.
Xie L, Hayashida S, Furue M.
J Cutan Pathol. 2011 Feb 24. doi: 10.1111/j.1600-0560.2011.01689.x. [Epub ahead of print]
PMID: 21352264 [PubMed - as supplied by publisher]
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57.
Adhesion-dependent Skp2 transcription requires selenocysteine tRNA gene transcription activiating factor (STAF).
Hernandez-Negrete I, Sala-Newby GB, Perl A, Kunkel GR, Newby AC, Bond M.
Biochem J. 2011 Feb 25. [Epub ahead of print]
PMID: 21352097 [PubMed - as supplied by publisher]
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58.
miR-145, miR-133a and miR-133b: Tumor-suppressive miRNAs target FSCN1 in esophageal squamous cell carcinoma.
Kano M, Seki N, Kikkawa N, Fujimura L, Hoshino I, Akutsu Y, Chiyomaru T, Enokida H, Nakagawa M, Matsubara H.
Int J Cancer. 2010 Dec 15;127(12):2804-14. doi: 10.1002/ijc.25284.
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59.
Drosophila gustatory preference behaviors require the atypical soluble guanylyl cyclases.
Vermehren-Schmaedick A, Scudder C, Timmermans W, Morton DB.
J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2011 Feb 25. [Epub ahead of print]
PMID: 21350862 [PubMed - as supplied by publisher]
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60.
Ectopic gene conversions in the genome of ten hemiascomycete yeast species.
Morris RT, Drouin G.
Int J Evol Biol. 2010 Nov 25;2011:970768.
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Free full text

Title: Re: AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Mar 2nd, 2011 at 3:50pm
Unique Evolution of Symbiobacterium thermophilum Suggested from Gene Content and Orthologous Protein Sequence Comparisons.
Oshima K, Ueda K, Beppu T, Nishida H.
Int J Evol Biol. 2010 Dec 22;2011:376831.
PMID: 21350630 [PubMed - in process] Free PMC Article
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62.
MOS1 epigenetically regulates the expression of plant Resistance gene SNC1.
Li Y, Dong O, Johnson K, Zhang Y.
Plant Signal Behav. 2011 Mar 1;6(3). [Epub ahead of print]
PMID: 21350329 [PubMed - as supplied by publisher]
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63.
The Transcription Factor ELF4 Controls Quiescence of Endothelial Cells and Their Resistance to Myeloablative Treatments in Bone Marrow.
Sivina M, Yamada T, Park CS, Puppi M, Coskun S, Hirschi K, Lacorazza HD.
Arterioscler Thromb Vasc Biol. 2011 Feb 24. [Epub ahead of print]
PMID: 21350194 [PubMed - as supplied by publisher]
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64.
Animal models for the study of liver fibrosis: New insights from knockout mouse models.
Hayashi H, Sakai T.
Am J Physiol Gastrointest Liver Physiol. 2011 Feb 24. [Epub ahead of print]
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65.
Cdx mediates neural tube closure through transcriptional regulation of the planar cell polarity gene Ptk7.
Savory JG, Mansfield M, Rijli FM, Lohnes D.
Development. 2011 Feb 24. [Epub ahead of print]
PMID: 21350009 [PubMed - as supplied by publisher]
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66.
A CTRP5 Gene S163R mutation Knock-In Mouse Model for Late-Onset Retinal Degeneration.
Chavali VR, Khan NW, Cuckras CA, Bartsch DU, Jablonski MM, Ayyagari R.
Hum Mol Genet. 2011 Feb 24. [Epub ahead of print]
PMID: 21349921 [PubMed - as supplied by publisher]
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67.
A clinically complex form of dominant optic atrophy (OPA8) maps on chromosome 16.
Carelli V, Schimpf S, Fuhrmann N, Valentino ML, Zanna C, Iommarini L, Papke M, Schaich S, Tippmann S, Baumann B, Barboni P, Longanesi L, Rugolo M, Ghelli A, Alavi M, Youle R, Bucchi L, Carroccia R, Giannoccaro MP, Tonon C, Lodi R, Cenacchi G, Montagna P, Liguori R, Wissinger B.
Hum Mol Genet. 2011 Feb 24. [Epub ahead of print]
PMID: 21349918 [PubMed - as supplied by publisher]
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68.
Disease-associated GPR56 mutations cause bilateral frontoparietal polymicrogyria via multiple mechanisms.
Chiang NY, Hsiao CC, Huang YS, Chen HY, Hsieh IJ, Chang GW, Lin HH.
J Biol Chem. 2011 Feb 24. [Epub ahead of print]
PMID: 21349848 [PubMed - as supplied by publisher] Free Article
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69.
Pro-inflammatory and pro-apoptotic responses of TNF-α stimulated bovine mammary endothelial cells.
Aitken SL, Corl CM, Sordillo LM.
Vet Immunol Immunopathol. 2011 Feb 4. [Epub ahead of print]
PMID: 21349589 [PubMed - as supplied by publisher]
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70.
The distal v(h) gene cluster of the igh locus contains distinct regulatory elements with pax5 transcription factor-dependent activity in pro-B cells.
Ebert A, McManus S, Tagoh H, Medvedovic J, Salvagiotto G, Novatchkova M, Tamir I, Sommer A, Jaritz M, Busslinger M.
Immunity. 2011 Feb 25;34(2):175-87.
PMID: 21349430 [PubMed - in process]
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71.
Ecrg4 expression and its product augurin in the choroid plexus: impact on fetal brain development, cerebrospinal fluid homeostasis and neuroprogenitor cell response to CNS injury.
Gonzalez AM, Podvin S, Lin SY, Miller MC, Botfield H, Leadbeater WE, Roberton A, Dang X, Knowling SE, Cardenas-Galindo E, Donahue JE, Stopa EG, Johanson CE, Coimbra R, Eliceiri BP, Baird A.
Fluids Barriers CNS. 2011 Jan 18;8(1):6.
PMID: 21349154 [PubMed - in process] Free PMC Article
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72.
Allelic Expression Imbalance of TP53 Mutated and Polymorphic Alleles in Head and Neck Tumors.
Ganci F, Conti S, Fontemaggi G, Manciocco V, Donzelli S, Covello R, Muti P, Strano S, Blandino G, Spriano G.
OMICS. 2011 Feb 24. [Epub ahead of print]
PMID: 21348641 [PubMed - as supplied by publisher]
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73.
Gene Expression Profile and Mutational Analysis of DNA Mismatch Repair Genes in Carcinoma Prostate in Indian Population.
Soni A, Bansal A, Singh LC, Mishra AK, Majumdar M, Regina T, Mohanty NK, Saxena S.
OMICS. 2011 Feb 24. [Epub ahead of print]
PMID: 21348638 [PubMed - as supplied by publisher]
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74.
Genetic basis of chronic pancreatitis in Asia Pacific region.
Reddy DN, Prasad SS.
J Gastroenterol Hepatol. 2011 Mar;26 Suppl 2:2-5. doi: 10.1111/j.1440-1746.2010.06598.x.
PMID: 21323990 [PubMed - in process]
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75.
A missense mutation in the transcription factor Foxo3a causes teratomas and oocyte abnormalities in mice.
Youngson NA, Vickaryous N, van der Horst A, Epp T, Harten S, Fleming JS, Khanna KK, de Kretser DM, Whitelaw E.
Mamm Genome. 2011 Feb 24. [Epub ahead of print]
PMID: 21347845 [PubMed - as supplied by publisher]
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76.
Mapping of Genetic Deletions on Chromosome 3 in Colorectal Cancer: Loss of 3p25-pter is Associated with Distant Metastasis and Poor Survival.
Tsai MH, Fang WH, Lin SH, Tzeng ST, Huang CS, Yen SJ, Chou SJ, Yang YC.
Ann Surg Oncol. 2011 Feb 23. [Epub ahead of print]
PMID: 21347784 [PubMed - as supplied by publisher]
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77.
Molecular Profiling of Colon Tumors: The Search for Clinically Relevant Biomarkers of Progression, Prognosis, Therapeutics, and Predisposition.
Bacolod MD, Barany F.
Ann Surg Oncol. 2011 Feb 24. [Epub ahead of print]
PMID: 21347779 [PubMed - as supplied by publisher]
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78.
WWOX expression in colorectal cancer-a real-time quantitative RT-PCR study.
Zelazowski MJ, Płuciennik E, Pasz-Walczak G, Potemski P, Kordek R, Bednarek AK.
Tumour Biol. 2011 Feb 25. [Epub ahead of print]
PMID: 21347750 [PubMed - as supplied by publisher]
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79.
Correction: disruption of the abdominal-B promoter tethering element results in a loss of long-range enhancer-directed hox gene expression in Drosophila.
Ho MC, Schiller BJ, Akbari OS, Bae E, Drewell RA.
PLoS One. 2011 Feb 9;6(2). doi: 10.1371/annotation/613079ca-aeae-4d29-bc5c-aa7202e6993e.
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80.
Loss of Nuclear Activity of the FBXO7 Protein in Patients with Parkinsonian-Pyramidal Syndrome (PARK15).
Zhao T, De Graaff E, Breedveld GJ, Loda A, Severijnen LA, Wouters CH, Verheijen FW, Dekker MC, Montagna P, Willemsen R, Oostra BA, Bonifati V.
PLoS One. 2011 Feb 11;6(2):e16983.
PMID: 21347293 [PubMed - in process] Free PMC Article
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The Genome Sequence of the Leaf-Cutter Ant Atta cephalotes Reveals Insights into Its Obligate Symbiotic Lifestyle.
Suen G, Teiling C, Li L, Holt C, Abouheif E, Bornberg-Bauer E, Bouffard P, Caldera EJ, Cash E, Cavanaugh A, Denas O, Elhaik E, Favé MJ, Gadau J, Gibson JD, Graur D, Grubbs KJ, Hagen DE, Harkins TT, Helmkampf M, Hu H, Johnson BR, Kim J, Marsh SE, Moeller JA, Muñoz-Torres MC, Murphy MC, Naughton MC, Nigam S, Overson R, Rajakumar R, Reese JT, Scott JJ, Smith CR, Tao S, Tsutsui ND, Viljakainen L, Wissler L, Yandell MD, Zimmer F, Taylor J, Slater SC, Clifton SW, Warren WC, Elsik CG, Smith CD, Weinstock GM, Gerardo NM, Currie CR.
PLoS Genet. 2011 Feb 10;7(2):e1002007.
PMID: 21347285 [PubMed - in process] Free PMC Article
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82.
An In Vitro Model That Recapitulates the Epithelial to Mesenchymal Transition (EMT) in Human Breast Cancer.
Katz E, Dubois-Marshall S, Sims AH, Gautier P, Caldwell H, Meehan RR, Harrison DJ.
PLoS One. 2011 Feb 15;6(2):e17083.
PMID: 21347235 [PubMed - in process] Free PMC Article
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83.
Neuromuscular Junction Defects in Mice with Mutation of dynein heavy chain 1.
Courchesne SL, Pazyra-Murphy MF, Lee DJ, Segal RA.
PLoS One. 2011 Feb 4;6(2):e16753.
PMID: 21346813 [PubMed - in process] Free PMC Article
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84.
Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome.
Liu GH, Barkho BZ, Ruiz S, Diep D, Qu J, Yang SL, Panopoulos AD, Suzuki K, Kurian L, Walsh C, Thompson J, Boue S, Fung HL, Sancho-Martinez I, Zhang K, Iii JY, Belmonte JC.
Nature. 2011 Feb 23. [Epub ahead of print]
PMID: 21346760 [PubMed - as supplied by publisher]
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85.
A gene expression signature from human breast cancer cells with acquired hormone independence identifies MYC as a mediator of antiestrogen resistance.
Miller TW, Balko JM, Ghazoui Z, Dunbier AK, Anderson H, Dowsett M, Gonzalez-Angulo AM, Mills GB, Miller WR, Wu H, Shyr Y, Arteaga CL.
Clin Cancer Res. 2011 Feb 23. [Epub ahead of print]
PMID: 21346144 [PubMed - as supplied by publisher]
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86.
MUC1-C ONCOPROTEIN IS A TARGET FOR SMALL MOLECULE INHIBITORS.
Zhou J, Rajabi H, Kufe DW.
Mol Pharmacol. 2011 Feb 23. [Epub ahead of print]
PMID: 21346142 [PubMed - as supplied by publisher] Free Article
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87.
HFE Gene Variants Affect Iron in the Brain.
Nandar W, Connor JR.
J Nutr. 2011 Feb 23. [Epub ahead of print]
PMID: 21346098 [PubMed - as supplied by publisher]
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88.
The Genetics of Bone Loss: Challenges and Prospects.
Mitchell BD, Yerges-Armstrong LM.
J Clin Endocrinol Metab. 2011 Feb 23. [Epub ahead of print]
PMID: 21346070 [PubMed - as supplied by publisher]
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89.
Gut mucosal viral reservoir in HIV infected patients is not the major source of rebound plasma viremia following HAART interruption.
Lerner P, Guadalupe M, Donovan R, Hung J, Flamm J, Prindiville T, Sankaran-Walters S, Syvanen M, Wong JK, George MD, Dandekar S.
J Virol. 2011 Feb 23. [Epub ahead of print]
PMID: 21345945 [PubMed - as supplied by publisher]
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90.
The Gαq signal in osteoblasts is inhibitory to the osteoanabolic action of PTH.
Ogata N, Shinoda Y, Wettschureck N, Offermans S, Takeda S, Nakamura K, Segre GV, Chung UI, Kawaguchi H.
J Biol Chem. 2011 Feb 23. [Epub ahead of print]
PMID: 21345793 [PubMed - as supplied by publisher] Free Article
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91.
Use of TILLING and robotised enzyme assays to generate an allelic series of Arabidopsis thaliana mutants with altered ADP-glucose pyrophosphorylase activity.
Hädrich N, Gibon Y, Schudoma C, Altmann T, Lunn JE, Stitt M.
J Plant Physiol. 2011 Feb 21. [Epub ahead of print]
PMID: 21345514 [PubMed - as supplied by publisher]
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92.
Gene Regulation in the Rat Prefrontal Cortex After Learning with or Without Cholinergic Insult.
Paban V, Chambon C, Farioli F, Alescio-Lautier B.
Neurobiol Learn Mem. 2011 Feb 20. [Epub ahead of print]
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93.
CYLD: a deubiquitination enzyme with multiple roles in cancer.
Massoumi R.
Future Oncol. 2011 Feb;7(2):285-97.
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94.
A novel homozygous missense mutation (c.610G>A, p.Gly204Ser) in the WNT7A gene causes tetra-amelia in two Saudi families.
Eyaid W, Al-Qattan MM, Al Abdulkareem I, Fetaini N, Al Balwi M.
Am J Med Genet A. 2011 Feb 22. doi: 10.1002/ajmg.a.33717. [Epub ahead of print]
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95.
mRNA and protein levels of FUS, EWSR1, and TAF15 are upregulated in liposarcoma.
Spitzer JI, Ugras S, Runge S, Decarolis P, Antonescu C, Tuschl T, Singer S.
Genes Chromosomes Cancer. 2011 Feb 22. doi: 10.1002/gcc.20858. [Epub ahead of print]
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96.
Bone matrix regulates osteoclast differentiation and annexin A8 gene expression.
Crotti TN, O'Sullivan RP, Shen Z, Flannery MR, Fajardo RJ, Ross FP, Goldring SR, McHugh KP.
J Cell Physiol. 2011 Feb 22. doi: 10.1002/jcp.22699. [Epub ahead of print]
PMID: 21344395 [PubMed - as supplied by publisher]
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97.
Ubc9 mediates nuclear localization and growth suppression of BRCA1 and BRCA1a proteins.
Qin Y, Xu J, Aysola K, Begum N, Reddy V, Chai Y, Grizzle WE, Partridge EE, Reddy ES, Rao VN.
J Cell Physiol. 2011 Feb 22. doi: 10.1002/jcp.22695. [Epub ahead of print]
PMID: 21344391 [PubMed - as supplied by publisher]
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98.
Global deficits in development, function, and gene expression in the endocrine pancreas in a deletion mouse model of Prader-Willi syndrome.
Stefan M, Simmons RA, Bertera S, Trucco MM, Esni F, Drain P, Nicholls RD.
Am J Physiol Endocrinol Metab. 2011 Feb 22. [Epub ahead of print]
PMID: 21343540 [PubMed - as supplied by publisher]
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99.
Comparative Genome Sequencing of an Isogenic Pair of USA800 Clinical MRSA Isolates Obtained Before and After Daptomycin Treatment Failure.
Boyle-Vavra S, Jones M, Gourley BL, Holmes M, Ruf R, Balsam AR, Boulware DR, Kline S, Jawahir S, Devries A, Peterson SN, Daum RS.
Antimicrob Agents Chemother. 2011 Feb 22. [Epub ahead of print]
PMID: 21343446 [PubMed - as supplied by publisher]
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100.
The Keep On Going (KEG) protein of Arabidopsis Recruits the Enhanced Disease Resistance 1 (EDR1) Protein to TGN/EE vesicles.
Gu Y, Innes RW.
Plant Physiol. 2011 Feb 22. [Epub ahead of print]
PMID: 21343429 [PubMed - as supplied by publisher] Free Article
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Title: Re: AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Mar 2nd, 2011 at 3:51pm
Here is a new set of articles on gene loss in humans and animals.

1. Homozygous deletion mapping in myeloma samples identifies genes and an expression signature relevant to pathogenesis and outcome.
Dickens NJ, Walker BA, Leone PE, Johnson DC, Brito JL, Zeisig A, Jenner MW, Boyd KD, Gonzalez D, Gregory WM, Ross FM, Davies FE, Morgan GJ.
Clin Cancer Res. 2010 Mar 15;16(6):1856-64. Epub 2010 Mar 9.
PMID: 20215539 [PubMed - indexed for MEDLINE] Free PMC Article
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2.
Effects of adiposity and 30 days of caloric restriction upon protein metabolism in moderately vs. severely obese women.
Henderson GC, Nadeau D, Horton ES, Nair KS.
Obesity (Silver Spring). 2010 Jun;18(6):1135-42. Epub 2010 Feb 4.
PMID: 20134416 [PubMed - indexed for MEDLINE] Free PMC Article
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3.
MGMT promoter methylation is prognostic but not predictive for outcome to adjuvant PCV chemotherapy in anaplastic oligodendroglial tumors: a report from EORTC Brain Tumor Group Study 26951.
van den Bent MJ, Dubbink HJ, Sanson M, van der Lee-Haarloo CR, Hegi M, Jeuken JW, Ibdaih A, Brandes AA, Taphoorn MJ, Frenay M, Lacombe D, Gorlia T, Dinjens WN, Kros JM.
J Clin Oncol. 2009 Dec 10;27(35):5881-6. Epub 2009 Nov 9.
PMID: 19901104 [PubMed - indexed for MEDLINE] Free PMC Article
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4.
Safety and tolerability of putaminal AADC gene therapy for Parkinson disease.
Christine CW, Starr PA, Larson PS, Eberling JL, Jagust WJ, Hawkins RA, VanBrocklin HF, Wright JF, Bankiewicz KS, Aminoff MJ.
Neurology. 2009 Nov 17;73(20):1662-9. Epub 2009 Oct 14.
PMID: 19828868 [PubMed - indexed for MEDLINE] Free PMC Article
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5.
A novel thromboxane A2 receptor D304N variant that abrogates ligand binding in a patient with a bleeding diathesis.
Mumford AD, Dawood BB, Daly ME, Murden SL, Williams MD, Protty MB, Spalton JC, Wheatley M, Mundell SJ, Watson SP.
Blood. 2010 Jan 14;115(2):363-9. Epub 2009 Oct 14.
PMID: 19828703 [PubMed - indexed for MEDLINE] Free Article
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6.
A nonsynonymous SNP within PCDH15 is associated with lipid traits in familial combined hyperlipidemia.
Huertas-Vazquez A, Plaisier CL, Geng R, Haas BE, Lee J, Greevenbroek MM, van der Kallen C, de Bruin TW, Taskinen MR, Alagramam KN, Pajukanta P.
Hum Genet. 2010 Jan;127(1):83-9. Epub 2009 Oct 9.
PMID: 19816713 [PubMed - indexed for MEDLINE] Free PMC Article
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7.
Fractionated subcutaneous rituximab is well-tolerated and preserves CD20 expression on tumor cells in patients with chronic lymphocytic leukemia.
Aue G, Lindorfer MA, Beum PV, Pawluczkowycz AW, Vire B, Hughes T, Taylor RP, Wiestner A.
Haematologica. 2010 Feb;95(2):329-32. Epub 2009 Aug 13.
PMID: 19679883 [PubMed - indexed for MEDLINE] Free PMC Article
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8.
A functional SNP in the regulatory region of the decay-accelerating factor gene associates with extraocular muscle pareses in myasthenia gravis.
Heckmann JM, Uwimpuhwe H, Ballo R, Kaur M, Bajic VB, Prince S.
Genes Immun. 2010 Jan;11(1):1-10. Epub 2009 Aug 13.
PMID: 19675582 [PubMed - indexed for MEDLINE] Free PMC Article
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9.
Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukemia patients: on behalf of Gruppo Italiano Malattie Ematologiche dell'Adulto Acute Leukemia Working Party (GIMEMA AL WP).
Iacobucci I, Storlazzi CT, Cilloni D, Lonetti A, Ottaviani E, Soverini S, Astolfi A, Chiaretti S, Vitale A, Messa F, Impera L, Baldazzi C, D'Addabbo P, Papayannidis C, Lonoce A, Colarossi S, Vignetti M, Piccaluga PP, Paolini S, Russo D, Pane F, Saglio G, Baccarani M, Foà R, Martinelli G.
Blood. 2009 Sep 3;114(10):2159-67. Epub 2009 Jul 9. Erratum in: Blood. 2010 Sep 23;116(12):2196.
PMID: 19589926 [PubMed - indexed for MEDLINE] Free Article
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10.
Expression of aryl hydrocarbon receptor (AHR) and AHR-interacting protein in pituitary adenomas: pathological and clinical implications.
Jaffrain-Rea ML, Angelini M, Gargano D, Tichomirowa MA, Daly AF, Vanbellinghen JF, D'Innocenzo E, Barlier A, Giangaspero F, Esposito V, Ventura L, Arcella A, Theodoropoulou M, Naves LA, Fajardo C, Zacharieva S, Rohmer V, Brue T, Gulino A, Cantore G, Alesse E, Beckers A.
Endocr Relat Cancer. 2009 Sep;16(3):1029-43. Epub 2009 Jun 25.
PMID: 19556287 [PubMed - indexed for MEDLINE] Free Article
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11.
Large-scale mRNA analysis of female skeletal muscles during 60 days of bed rest with and without exercise or dietary protein supplementation as countermeasures.
Chopard A, Lecunff M, Danger R, Lamirault G, Bihouee A, Teusan R, Jasmin BJ, Marini JF, Leger JJ.
Physiol Genomics. 2009 Aug 7;38(3):291-302. Epub 2009 May 26.
PMID: 19470803 [PubMed - indexed for MEDLINE] Free Article
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12.
15-Hydroxyprostaglandin dehydrogenase inactivation as a mechanism of resistance to celecoxib chemoprevention of colon tumors.
Yan M, Myung SJ, Fink SP, Lawrence E, Lutterbaugh J, Yang P, Zhou X, Liu D, Rerko RM, Willis J, Dawson D, Tai HH, Barnholtz-Sloan JS, Newman RA, Bertagnolli MM, Markowitz SD.
Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9409-13. Epub 2009 May 22.
PMID: 19470469 [PubMed - indexed for MEDLINE] Free PMC Article
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13.
Meta-analysis of expression signatures of muscle atrophy: gene interaction networks in early and late stages.
Calura E, Cagnin S, Raffaello A, Laveder P, Lanfranchi G, Romualdi C.
BMC Genomics. 2008 Dec 23;9:630.
PMID: 19108710 [PubMed - indexed for MEDLINE] Free PMC Article
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14.
Fragile histidine triad gene inactivation in lung cancer: the European Early Lung Cancer project.
Verri C, Roz L, Conte D, Liloglou T, Livio A, Vesin A, Fabbri A, Andriani F, Brambilla C, Tavecchio L, Calarco G, Calabrò E, Mancini A, Tosi D, Bossi P, Field JK, Brambilla E, Sozzi G; EUELC Consortium.
Am J Respir Crit Care Med. 2009 Mar 1;179(5):396-401. Epub 2008 Dec 18.
PMID: 19096006 [PubMed - indexed for MEDLINE] Free Article
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15.
Enhanced cortisol production rates, free cortisol, and 11beta-HSD-1 expression correlate with visceral fat and insulin resistance in men: effect of weight loss.
Purnell JQ, Kahn SE, Samuels MH, Brandon D, Loriaux DL, Brunzell JD.
Am J Physiol Endocrinol Metab. 2009 Feb;296(2):E351-7. Epub 2008 Dec 2.
PMID: 19050176 [PubMed - indexed for MEDLINE] Free PMC Article
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16.
Accuracy of combined protein gene product 9.5 and parafibromin markers for immunohistochemical diagnosis of parathyroid carcinoma.
Howell VM, Gill A, Clarkson A, Nelson AE, Dunne R, Delbridge LW, Robinson BG, Teh BT, Gimm O, Marsh DJ.
J Clin Endocrinol Metab. 2009 Feb;94(2):434-41. Epub 2008 Nov 18.
PMID: 19017757 [PubMed - indexed for MEDLINE] Free Article
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17.
Aging differentially affects human skeletal muscle microRNA expression at rest and after an anabolic stimulus of resistance exercise and essential amino acids.
Drummond MJ, McCarthy JJ, Fry CS, Esser KA, Rasmussen BB.
Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1333-40. Epub 2008 Sep 30.
PMID: 18827171 [PubMed - indexed for MEDLINE] Free PMC Article
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18.
Epithelioid trophoblastic tumor: comparative genomic hybridization and diagnostic DNA genotyping.
Xu ML, Yang B, Carcangiu ML, Hui P.
Mod Pathol. 2009 Feb;22(2):232-8. Epub 2008 Sep 26.
PMID: 18820674 [PubMed - indexed for MEDLINE] Free Article
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19.
Human mutation in the anti-apoptotic heat shock protein 20 abrogates its cardioprotective effects.
Nicolaou P, Knöll R, Haghighi K, Fan GC, Dorn GW 2nd, Hasenfub G, Kranias EG.
J Biol Chem. 2008 Nov 28;283(48):33465-71. Epub 2008 Sep 12.
PMID: 18790732 [PubMed - indexed for MEDLINE] Free PMC Article
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20.
Contribution of energy restriction and macronutrient composition to changes in adipose tissue gene expression during dietary weight-loss programs in obese women.
Capel F, Viguerie N, Vega N, Dejean S, Arner P, Klimcakova E, Martinez JA, Saris WH, Holst C, Taylor M, Oppert JM, Sørensen TI, Clément K, Vidal H, Langin D.
J Clin Endocrinol Metab. 2008 Nov;93(11):4315-22. Epub 2008 Sep 9.
PMID: 18782868 [PubMed - indexed for MEDLINE] Free Article
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Functional and structural profiling of the human thrombopoietin gene promoter.
Dördelmann C, Telgmann R, Brand E, Hagedorn C, Schröer B, Hasenkamp S, Baumgart P, Kleine-Katthöfer P, Paul M, Brand-Herrmann SM.
J Biol Chem. 2008 Sep 5;283(36):24382-91. Epub 2008 Jul 9.
PMID: 18617523 [PubMed - indexed for MEDLINE] Free Article
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22.
The clinical phenotype of Lynch syndrome due to germ-line PMS2 mutations.
Senter L, Clendenning M, Sotamaa K, Hampel H, Green J, Potter JD, Lindblom A, Lagerstedt K, Thibodeau SN, Lindor NM, Young J, Winship I, Dowty JG, White DM, Hopper JL, Baglietto L, Jenkins MA, de la Chapelle A.
Gastroenterology. 2008 Aug;135(2):419-28. Epub 2008 May 2.
PMID: 18602922 [PubMed - indexed for MEDLINE] Free PMC Article
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23.
Gene-environment interaction in the onset of eczema in infancy: filaggrin loss-of-function mutations enhanced by neonatal cat exposure.
Bisgaard H, Simpson A, Palmer CN, Bønnelykke K, McLean I, Mukhopadhyay S, Pipper CB, Halkjaer LB, Lipworth B, Hankinson J, Woodcock A, Custovic A.
PLoS Med. 2008 Jun 24;5(6):e131.
PMID: 18578563 [PubMed - indexed for MEDLINE] Free PMC Article
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24.
CADM1 is a strong neuroblastoma candidate gene that maps within a 3.72 Mb critical region of loss on 11q23.
Michels E, Hoebeeck J, De Preter K, Schramm A, Brichard B, De Paepe A, Eggert A, Laureys G, Vandesompele J, Speleman F.
BMC Cancer. 2008 Jun 17;8:173.
PMID: 18559103 [PubMed - indexed for MEDLINE] Free PMC Article
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25.
Clinical response after two cycles compared to HER2, Ki-67, p53, and bcl-2 in independently predicting a pathological complete response after preoperative chemotherapy in patients with operable carcinoma of the breast.
von Minckwitz G, Sinn HP, Raab G, Loibl S, Blohmer JU, Eidtmann H, Hilfrich J, Merkle E, Jackisch C, Costa SD, Caputo A, Kaufmann M; German Breast Group.
Breast Cancer Res. 2008;10(2):R30. Epub 2008 Apr 1.
PMID: 18380893 [PubMed - indexed for MEDLINE] Free PMC Article
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26.
Expression of ghrelin gene in peripheral blood mononuclear cells and plasma ghrelin concentrations in patients with metabolic syndrome.
Mager U, Kolehmainen M, de Mello VD, Schwab U, Laaksonen DE, Rauramaa R, Gylling H, Atalay M, Pulkkinen L, Uusitupa M.
Eur J Endocrinol. 2008 Apr;158(4):499-510.
PMID: 18362297 [PubMed - indexed for MEDLINE] Free Article
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27.
Peripheral endocannabinoid system activity in patients treated with sibutramine.
Engeli S, Heusser K, Janke J, Gorzelniak K, Bátkai S, Pacher P, Harvey-White J, Luft FC, Jordan J.
Obesity (Silver Spring). 2008 May;16(5):1135-7. Epub 2008 Mar 6.
PMID: 18356837 [PubMed - indexed for MEDLINE] Free PMC Article
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28.
REEP1 mutation spectrum and genotype/phenotype correlation in hereditary spastic paraplegia type 31.
Beetz C, Schüle R, Deconinck T, Tran-Viet KN, Zhu H, Kremer BP, Frints SG, van Zelst-Stams WA, Byrne P, Otto S, Nygren AO, Baets J, Smets K, Ceulemans B, Dan B, Nagan N, Kassubek J, Klimpe S, Klopstock T, Stolze H, Smeets HJ, Schrander-Stumpel CT, Hutchinson M, van de Warrenburg BP, Braastad C, Deufel T, Pericak-Vance M, Schöls L, de Jonghe P, Züchner S.
Brain. 2008 Apr;131(Pt 4):1078-86. Epub 2008 Mar 5.
PMID: 18321925 [PubMed - indexed for MEDLINE] Free PMC Article
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29.
Vascular endothelial growth factor protein levels and gene expression in peripheral monocytes after stenting: a randomized comparative study of sirolimus: eluting and bare metal stents.
Kochiadakis GE, Marketou ME, Panutsopulos D, Arfanakis DA, Skalidis EI, Igoumenidis NE, Hamilos MI, Sourvinos G, Chlouverakis G, Spandidos D, Vardas PE.
Eur Heart J. 2008 Mar;29(6):733-40. Epub 2008 Feb 27.
PMID: 18305085 [PubMed - indexed for MEDLINE] Free Article
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30.
Urinary messenger RNA expression of podocyte-associated molecules in patients with diabetic nephropathy treated by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker.
Wang G, Lai FM, Lai KB, Chow KM, Kwan BC, Li PK, Szeto CC.
Eur J Endocrinol. 2008 Mar;158(3):317-22.
PMID: 18299464 [PubMed - indexed for MEDLINE] Free Article
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31.
An inactivated vaccine to control the current H9N2 low pathogenic avian influenza in Korea.
Choi JG, Lee YJ, Kim YJ, Lee EK, Jeong OM, Sung HW, Kim JH, Kwon JH.
J Vet Sci. 2008 Mar;9(1):67-74.
PMID: 18296890 [PubMed - indexed for MEDLINE] Free PMC Article
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32.
A transcriptional profiling meta-analysis reveals a core EWS-FLI gene expression signature.
Hancock JD, Lessnick SL.
Cell Cycle. 2008 Jan 15;7(2):250-6. Epub 2007 Oct 30.
PMID: 18256529 [PubMed - indexed for MEDLINE] Free Article
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33.
Changes in CCR2 chemokine receptor expression and plasma MCP-1 concentration after the implantation of bare metal stents versus sirolimus-eluting stents in patients with stable angina.
Sako H, Miura S, Iwata A, Nishikawa H, Kawamura A, Matsuo K, Shirai K, Saku K.
Intern Med. 2008;47(1):7-13. Epub 2008 Jan 1.
PMID: 18175998 [PubMed - indexed for MEDLINE] Free Article
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34.
Adipose gene expression prior to weight loss can differentiate and weakly predict dietary responders.
Mutch DM, Temanni MR, Henegar C, Combes F, Pelloux V, Holst C, Sørensen TI, Astrup A, Martinez JA, Saris WH, Viguerie N, Langin D, Zucker JD, Clément K.
PLoS One. 2007 Dec 19;2(12):e1344.
PMID: 18094752 [PubMed - indexed for MEDLINE] Free PMC Article
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35.
Fatty acid desaturase regulation in adipose tissue by dietary composition is independent of weight loss and is correlated with the plasma triacylglycerol response.
Mangravite LM, Dawson K, Davis RR, Gregg JP, Krauss RM.
Am J Clin Nutr. 2007 Sep;86(3):759-67.
PMID: 17823443 [PubMed - indexed for MEDLINE] Free Article
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36.
Colorectal cancer risks in relatives of young-onset cases: is risk the same across all first-degree relatives?
Boardman LA, Morlan BW, Rabe KG, Petersen GM, Lindor NM, Nigon SK, Goldberg J, Gallinger S.
Clin Gastroenterol Hepatol. 2007 Oct;5(10):1195-8. Epub 2007 Aug 16.
PMID: 17702662 [PubMed - indexed for MEDLINE] Free PMC Article
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37.
Gene mapping and expression analysis of 16q loss of heterozygosity identifies WWOX and CYLD as being important in determining clinical outcome in multiple myeloma.
Jenner MW, Leone PE, Walker BA, Ross FM, Johnson DC, Gonzalez D, Chiecchio L, Dachs Cabanas E, Dagrada GP, Nightingale M, Protheroe RK, Stockley D, Else M, Dickens NJ, Cross NC, Davies FE, Morgan GJ.
Blood. 2007 Nov 1;110(9):3291-300. Epub 2007 Jul 3.
PMID: 17609426 [PubMed - indexed for MEDLINE] Free Article
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38.
IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth.
Lofqvist C, Chen J, Connor KM, Smith AC, Aderman CM, Liu N, Pintar JE, Ludwig T, Hellstrom A, Smith LE.
Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10589-94. Epub 2007 Jun 13.
PMID: 17567756 [PubMed - indexed for MEDLINE] Free PMC Article
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39.
Meta-analysis of myeloperoxidase G-463/A polymorphism in anti-neutrophil cytoplasmic autoantibody-positive vasculitis.
Rajp A, Adu D, Savage CO.
Clin Exp Immunol. 2007 Aug;149(2):251-6. Epub 2007 May 22.
PMID: 17521322 [PubMed - indexed for MEDLINE] Free PMC Article
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40.
Dietary carbohydrate modification induces alterations in gene expression in abdominal subcutaneous adipose tissue in persons with the metabolic syndrome: the FUNGENUT Study.
Kallio P, Kolehmainen M, Laaksonen DE, Kekäläinen J, Salopuro T, Sivenius K, Pulkkinen L, Mykkänen HM, Niskanen L, Uusitupa M, Poutanen KS.
Am J Clin Nutr. 2007 May;85(5):1417-27.
PMID: 17490981 [PubMed - indexed for MEDLINE] Free Article
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Trace element supplementation after major burns increases burned skin trace element concentrations and modulates local protein metabolism but not whole-body substrate metabolism.
Berger MM, Binnert C, Chiolero RL, Taylor W, Raffoul W, Cayeux MC, Benathan M, Shenkin A, Tappy L.
Am J Clin Nutr. 2007 May;85(5):1301-6.
PMID: 17490966 [PubMed - indexed for MEDLINE] Free Article
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42.
The human Shwachman-Diamond syndrome protein, SBDS, associates with ribosomal RNA.
Ganapathi KA, Austin KM, Lee CS, Dias A, Malsch MM, Reed R, Shimamura A.
Blood. 2007 Sep 1;110(5):1458-65. Epub 2007 May 2.
PMID: 17475909 [PubMed - indexed for MEDLINE] Free PMC Article
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43.
Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss.
Montano M, Flanagan JN, Jiang L, Sebastiani P, Rarick M, LeBrasseur NK, Morris CA, Jasuja R, Bhasin S.
J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. Epub 2007 Apr 17.
PMID: 17440010 [PubMed - indexed for MEDLINE] Free Article
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44.
Matrix-comparative genomic hybridization from multicenter formalin-fixed paraffin-embedded colorectal cancer tissue blocks.
Fensterer H, Radlwimmer B, Sträter J, Buchholz M, Aust DE, Julié C, Radvanyi F, Nordlinger B, Belluco C, Van Cutsem E, Köhne CH, Kestler HA, Schwaenen C, Nessling M, Lutz MP, Lichter P, Gress TM; EORTC Gastrointestinal (GI) Group.
BMC Cancer. 2007 Apr 2;7:58.
PMID: 17407575 [PubMed - indexed for MEDLINE] Free Article
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45.
Effect of marked weight loss on adiponectin gene expression and plasma concentrations.
Coughlin CC, Finck BN, Eagon JC, Halpin VJ, Magkos F, Mohammed BS, Klein S.
Obesity (Silver Spring). 2007 Mar;15(3):640-5.
PMID: 17372314 [PubMed - indexed for MEDLINE] Free Article
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46.
Loss of membranous Ep-CAM in budding colorectal carcinoma cells.
Gosens MJ, van Kempen LC, van de Velde CJ, van Krieken JH, Nagtegaal ID.
Mod Pathol. 2007 Feb;20(2):221-32.
PMID: 17361206 [PubMed - indexed for MEDLINE] Free Article
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47.
Calorie restriction increases muscle mitochondrial biogenesis in healthy humans.
Civitarese AE, Carling S, Heilbronn LK, Hulver MH, Ukropcova B, Deutsch WA, Smith SR, Ravussin E; CALERIE Pennington Team.
PLoS Med. 2007 Mar;4(3):e76.
PMID: 17341128 [PubMed - indexed for MEDLINE] Free PMC Article
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48.
Sympathetic vasomotor tone determines blood pressure response to long-term sibutramine treatment.
Heusser K, Engeli S, Tank J, Diedrich A, Wiesner S, Janke J, Luft FC, Jordan J.
J Clin Endocrinol Metab. 2007 Apr;92(4):1560-3. Epub 2007 Feb 6.
PMID: 17284621 [PubMed - indexed for MEDLINE] Free Article
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49.
Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus.
Valencia X, Yarboro C, Illei G, Lipsky PE.
J Immunol. 2007 Feb 15;178(4):2579-88.
PMID: 17277168 [PubMed - indexed for MEDLINE] Free Article
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50.
Loss of fragile histidine triad protein expression in inflammatory bowel disease.
Xu CM, Qiao CH.
World J Gastroenterol. 2006 Dec 7;12(45):7355-60.
PMID: 17143956 [PubMed - indexed for MEDLINE] Free Article
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51.
Gene expression profiling of bovine skeletal muscle in response to and during recovery from chronic and severe undernutrition.
Lehnert SA, Byrne KA, Reverter A, Nattrass GS, Greenwood PL, Wang YH, Hudson NJ, Harper GS.
J Anim Sci. 2006 Dec;84(12):3239-50.
PMID: 17093216 [PubMed - indexed for MEDLINE] Free Article
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52.
Striosomes and mood dysfunction in Huntington's disease.
Tippett LJ, Waldvogel HJ, Thomas SJ, Hogg VM, van Roon-Mom W, Synek BJ, Graybiel AM, Faull RL.
Brain. 2007 Jan;130(Pt 1):206-21. Epub 2006 Oct 12.
PMID: 17040921 [PubMed - indexed for MEDLINE] Free Article
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53.
Oral salmon calcitonin reduces Lequesne's algofunctional index scores and decreases urinary and serum levels of biomarkers of joint metabolism in knee osteoarthritis.
Manicourt DH, Azria M, Mindeholm L, Thonar EJ, Devogelaer JP.
Arthritis Rheum. 2006 Oct;54(10):3205-11.
PMID: 17009253 [PubMed - indexed for MEDLINE] Free Article
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54.
Time-dependent effects of free fatty acids on glucose effectiveness in type 2 diabetes.
Kishore P, Tonelli J, Koppaka S, Fratila C, Bose A, Lee DE, Reddy K, Hawkins M.
Diabetes. 2006 Jun;55(6):1761-8.
PMID: 16731840 [PubMed - indexed for MEDLINE] Free Article
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55.
Age-related loss of associations between acute exercise-induced IL-6 and oxidative stress.
Sacheck JM, Cannon JG, Hamada K, Vannier E, Blumberg JB, Roubenoff R.
Am J Physiol Endocrinol Metab. 2006 Aug;291(2):E340-9. Epub 2006 Feb 28.
PMID: 16507605 [PubMed - indexed for MEDLINE] Free Article
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56.
Immune response to pneumococcal polysaccharides 4 and 14 in elderly and young adults: analysis of the variable heavy chain repertoire.
Kolibab K, Smithson SL, Rabquer B, Khuder S, Westerink MA.
Infect Immun. 2005 Nov;73(11):7465-76.
PMID: 16239548 [PubMed - indexed for MEDLINE] Free PMC Article
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57.
Tissue microarray analysis of Fas and FasL expressions in human non-small cell lung carcinomas; with reference to the p53 and bcl-2 overexpressions.
Myong NH.
J Korean Med Sci. 2005 Oct;20(5):770-6.
PMID: 16224150 [PubMed - indexed for MEDLINE] Free PMC Article
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58.
Molecular alterations in tumors and response to combination chemotherapy with gefitinib for advanced colorectal cancer.
Ogino S, Meyerhardt JA, Cantor M, Brahmandam M, Clark JW, Namgyal C, Kawasaki T, Kinsella K, Michelini AL, Enzinger PC, Kulke MH, Ryan DP, Loda M, Fuchs CS.
Clin Cancer Res. 2005 Sep 15;11(18):6650-6.
PMID: 16166444 [PubMed - indexed for MEDLINE] Free Article
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59.
Changes in adipose tissue gene expression with energy-restricted diets in obese women.
Dahlman I, Linder K, Arvidsson Nordström E, Andersson I, Lidén J, Verdich C, Sørensen TI, Arner P.
Am J Clin Nutr. 2005 Jun;81(6):1275-85. Erratum in: Am J Clin Nutr. 2005 Sep;82(3):709.
PMID: 15941876 [PubMed - indexed for MEDLINE] Free Article
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60.
Accuracy of revised Bethesda guidelines, microsatellite instability, and immunohistochemistry for the identification of patients with hereditary nonpolyposis colorectal cancer.
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Title: Re: AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Mar 2nd, 2011 at 3:55pm
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Title: Re: AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Mar 6th, 2011 at 2:56pm
The theory of evolution falls under the category that humans have an emotional problem called : The Earth Is Flat Syndrome.   I coined this to give a name to religious ideas in science.


English writer Samuel Rowbotham (1816–1885)

In 1883 he founded Zetetic Societies in England and New York, to which he shipped a thousand copies of Zetetic Astronomy. Challenges were issued in the New York Daily Graphic offering $10,000 to charity to anyone proving the Earth revolved on an axis.

Title: Re: AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Mar 12th, 2011 at 7:17pm
http://www.physorg.com/news/2010-11-spontaneous-mutations-important-mental-retardation.html

This link discusses genetic differences in a child that come from a sperm or an egg from the parents that has mutated.
 
All mutations tend to be bad, so this is just another one.

Title: Re: AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Mar 12th, 2011 at 7:22pm
"Children receive far less genetic mutations from their parents that it was previously believed, a new study suggests.

Scientists at the Seattle-based Institute for Systems Biology, the University of Utah and the University of Washington studied the entire family genome and found that each parent passes around 30 gene mutations to their children. Previously, scientists thought that children receive as much as 75 gene mutations from each parent, while the actual mutations rate is less than a half.

Scientists say that in most cases, genetic mutations do not affect child's health. The real number of gene mutations will also vary depending on the age of the parents. Father's age at conception plays a significant role in how many gene mutations will be passed. The risk of genetic disorders increases as father's age rises.

The study was published in the March 11 issue of Science Express."

Here is the problem with this use of the word "mutations".
Parents cannot pass on mutations.  Repeat that 100 times until you get it.  They pass on genetic information.
The mother has all her eggs at the time of birth.  Do you know that. This is common genetic knowledge. That means the eggs are fully made before the mother can screw them up. This is by design and to protect the progeny from the mothers mistakes.
This is one of the main reasons why sonomic mutations are made to take place separate from the genetic mutations. Thus reducing the chances of passing on the mistakes of the parents.
If 70% of all mutations are bad, then these 75 mutations  cannot be random, otherwise the child would never be born alive.  UNDERSTAND?
70% bad mutations  out of 75 = 52 random bad mutations.

Because the child lives and is healthy, these ARE NOT MUTATIONS.  They are genetic information from the parents genealogy.  These are programmed from the ancestors of the parents and now show up.

This means that part of the genetic information stored in the genome is not known to genetic scientists.  There are 3.2 billion base pairs, but only 25,000 or so that are active.  The other are there as, an unknown factor that no scientist has any clue about until they see some "action" from them.

I think we have a whole level of genetic coding that is unknown to "scientists" contained in the 3 plus billion unknown base pairs. 

So if a child is born healthy and has "different" gene coding they are not mutations, but are information contained in the parents genetics from ancestors.  This mixing is also part of what make people utterly unique.

Get this...There are no two people ever exactly alike. Not ever in all the time people have been reproducing.  They may have similarity, but never exact clones.

Title: Re: AlanCFAs idea of evidence for evolution PEER Papers.
Post by GoodScienceForYou on Apr 7th, 2011 at 3:05am
http://www.ncbi.nlm.nih.gov/pubmed/14525925

Gene loss, protein sequence divergence, gene dispensability, expression level, and interactivity are correlated in eukaryotic evolution.
Krylov DM, Wolf YI, Rogozin IB, Koonin EV.

National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA.
Abstract
Lineage-specific gene loss, to a large extent, accounts for the differences in gene repertoires between genomes, particularly among eukaryotes. We derived a parsimonious scenario of gene losses for eukaryotic orthologous groups (KOGs) from seven complete eukaryotic genomes. The scenario involves substantial gene loss in fungi, nematodes, and insects. Based on this evolutionary scenario and estimates of the divergence times between major eukaryotic phyla, we introduce a numerical measure, the propensity for gene loss (PGL). We explore the connection among the propensity of a gene to be lost in evolution (PGL value), protein sequence divergence, the effect of gene knockout on fitness, the number of protein-protein interactions, and expression level for the genes in KOGs. Significant correlations between PGL and each of these variables were detected. Genes that have a lower propensity to be lost in eukaryotic evolution accumulate fewer substitutions in their protein sequences and tend to be essential for the organism viability, tend to be highly expressed, and have many interaction partners. The dependence between PGL and gene dispensability and interactivity is much stronger than that for sequence evolution rate. Thus, propensity of a gene to be lost during evolution seems to be a direct reflection of its biological importance.

Title: Re: PEER REVIEWED AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Apr 7th, 2011 at 11:09am
Here we see the premise is to show evolution but the results show gene loss or stability.  The "revolving door" is the same thing repeating or gene loss only.
The wording is done in such a vague way as to mask the results, so read it carefully and it is clear that noting is supporting evolution. See the highlighted text.
http://www.ncbi.nlm.nih.gov/pubmed/21466698

"Expansion and functional diversification of a leucyl aminopeptidase family that encodes the major protein constituents of Drosophila sperm.
Dorus S, Wilkin EC, Karr TL.

Abstract
ABSTRACT:

BACKGROUND: The evolutionary diversification of gene families through gene creation (and loss) is a dynamic process believed to be critical to the evolution of functional novelty. Previous identification of a closely related family of eight annotated metalloprotease genes of the M17 Merops family in the Drosophila sperm proteome (termed, Sperm-LeucylAminoPeptidases, S-LAPs 1-8) led us to hypothesize that this gene family may have experienced such a diversification during insect evolution.

RESULTS: To assess putative functional activities of S-LAPs, we (i) demonstrated that all S-LAPs are specifically expressed in the testis, (ii) confirmed their presence in sperm by two-dimensional gel electrophoresis and mass spectrometry, (iii) determined that they represent a major portion of the total protein in sperm and (iv) identified aminopeptidase enzymatic activity in sperm extracts using LAP-specific substrates. Functionally significant divergence at the canonical M17 active site indicates that the largest phylogenetic group of S-LAPs lost catalytic activity and likely acquired novel, as yet undetermined, functions in sperm prior to the expansion of the gene family.

CONCLUSIONS: Comparative genomic and phylogenetic analyses revealed the dramatic expansion of the S-LAP gene family during Drosophila evolution and copy number heterogeneity in the genomes of related insects. This finding, in conjunction with the loss of catalytic activity and potential neofunctionalization amongst some family members, extends empirical support for pervasive "revolving door" turnover in the evolution of reproductive gene family composition and function."

Title: Re: PEER REVIEWED AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Apr 7th, 2011 at 3:03pm
Every single scientific paper written on DNA only shows de-evolution.  The use irrefutable, absolute evidence, that is physical and represents the defects which are shown to permeate throughout human kind and all multi cellular creatures.

This completely negates all the old religious BS of Evotards, forcing religious ideas of creatures evolving from some simpler life form and eventually become some complex creatures.

Please note If evolution were true, there would be no defects and no retardation no gene losses. There would only be fixes that continue to make things better.  YOu cannot have it both ways.  Either creatures "magically fix" and "mangically improve" or they don't.

Since we have ZERO DNA evidence of any net positive evolution towards more fit, more complex more intelligent, guess what?

Evolution is a pile or religious nonsense.  That is the conclusion, and it is verified in every single DNA study.
The conclusions of these poor believers is crap, because the evidence does not fit with any form of evolution.

You have to look at only the evidence and realize what is going on and forget this word "evolution" it is not even related to any creature on this earth.

Degradation is the real word. When you see one of these articles, just put in "genetic degradation" in place of "evolution" and you will see the truth of the matter, pretty clear.


Title: Re: PEER REVIEWED AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Apr 23rd, 2011 at 12:48am
MORE DE-EVOLVED humoids found:
(This crap dating system has to go.)

22 April 2011
Another missing link in human evolution?
Skeletons of Australopithecus sediba display a unusual mix of modern and primitive traits - sharing more features with early Homo specimens than any other known Australopithecus species, according to Darryl de Ruiter of Texas A&M University in College Station, USA.
     Researchers found the remains of at least four individuals - a youth, an older female, an 18-month-old infant and at least one other adult - who died when they fell into a 'death trap' in a cave about 2 million years ago at Malapa (South Africa).
     These particular individuals could not be ancestors of Homo because members of our genus were already living at the time when they fell into the pit. But, says Lee Berger of the University of the Witwatersrand in Johannesburg (South Africa), they might be late members of the australopithecine species that earlier gave rise to Homo, or a close relative that could shed light on that crucial ancestor.
     Anthropologists have long wondered which of several species of Australopithecus gave rise to the first members of our genus - with Lucy's north African species,  Australopithecus afarensis, as the leading candidate - and evidence is accumulating that the South African species formed an evolutionary connection between relatively apelike members of Australopithecus, and the Homo genus, which includes living people.
     Much uncertainty surrounds the identity of fossil members of the human evolutionary family between 3 million and 2 million years ago, says John Hawks of the University of Wisconsin, Madison (USA).

Edited from ScienceNews (18 April 2011), Science (19 April 2011), PhysOrg (20 April 2011)

Title: Re: PEER REVIEWED AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Apr 23rd, 2011 at 12:53am
This is a fine example of people trying, scrambling to avoid the obvious:  These are degenerated humans
It is clear as can be.

=============================================

MINNEAPOLIS, MINNESOTA—Finding one partial skeleton of an ancient member of the human family is the rarest of rare discoveries in human evolution. So, paleoanthropologists murmured in surprise at a meeting here Saturday when South African researchers announced that they had found at least four individuals of a new species of early human, Australopithecus sediba. The discoverers say that this hominin shows some surprisingly modern traits and its species may even be an ancestor of our own genus. “We really have found something very, very odd and very unexpected,” says discovery team leader Lee Berger of the University of the Witwatersrand in Johannesburg, South Africa. But other paleoanthropologists are waiting for more detailed analysis of the still-unpublished fossils before they agree on its identity or place in the human family tree.

The four hominin individuals died when they fell into a “death trap” in a cave about 2 million years ago at Malapa, South Africa, according to new dates reported by Berger in his talk at the annual meeting of the American Association of Physical Anthropologists (AAPA). In addition to the articulated partial skeletons of a youth and an older female unveiled last year in Science, the team members reported the discovery of bones of an 18-month-old infant and at least one other adult. This means they are getting a good look at Au. sediba’s development from infancy to old age. “It is going to be a remarkable record,” Berger said. “And we still haven’t found everything!”

In talks at AAPA and the annual meeting of the Paleoanthropology Society last week, Berger and members of his team sketched a quick portrait of Au. sediba, who lived at the mysterious time right after the emergence of our genus Homo between 2 million to 3 million years ago. Researchers have long wondered which of several species of Australopithecus gave rise to the first members of our genus, with Lucy’s species Au. afarensis as the leading candidate.

The trove of well-preserved bones includes clavicles, shoulder blades, and ribs as well as a complete skull, hand, foot, and two pelvises. The researchers called it an australopithecine—extinct members of the human family that lived 1 million to 4 million years ago in Africa—because it had a small brain the size of an ape's, and its “overall body plan” was like that of an australopithecine, team member Darryl de Ruiter of Texas A&M University in College Station said in a talk. It had long arms and a primitive thorax and heel like an ape, for example.

But the fossils also show some surprisingly modern traits usually found only in members of our own genus, Berger said. Two pelvises, in particular, are capacious and elongated in a way that looks quite Homo-like. In his talk on the fossils, Berger ticked off a list of other traits that were modern, including smaller teeth, short fingers, and an elongated thumb.

In a separate talk at the Paleoanthropology Society, Kristian Carlson of Indiana University, Bloomington, described the endocast, the impression left inside the skull by the brain. He said that the outer surface of the brain suggests that the forebrain, the uppermost part of the brain that extends from the forehead to the base of the skull, might be reorganized in a modern way. If so, Au. sediba’s brain and pelvis would have both begun to evolve into more modern shapes before the brain expanded—countering the view that the expanding brain drove the remodeling of the pelvis to accommodate bigger-brained babies.

These particular individuals could not be ancestors of Homo because members of our genus were already living at the time when these hominins fell into the pit at Malapa. But, Berger says, they might be late members of the australopithecine species that gave rise to Homo earlier, or a close relative that could shed light on that crucial ancestor.

Other researchers, who were able to examine casts of the fossils at the meeting, agreed that on first glance the fossils represent an unusual mix of primitive and more modern traits. But most thought it important to compare Au. sediba directly with other fossils of early Homo and Australopithecus in more detail before placing them on our family tree. “The pelvis does look more modern,” says paleoanthropologist Christopher Ruff of Johns Hopkins University in Baltimore, Maryland. “But that doesn’t mean it looks exactly like a modern human’s or that it gave rise to early Homo.”

Yet even if Au. sediba is an evolutionary dead end, William Kimbel of Arizona State University in Tempe says, “It does still shed light on the evolution of early Homo because we know nothing about the time period 1/2 million to 3/4 million years before Au. sediba.”
sn-a_sediba-thumb-800xauto-5973.jpg (128 KB | 315 )

Title: Re: PEER REVIEWED AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Apr 23rd, 2011 at 11:43pm
There is ONLY shown in DNA evidence a constant degradation to all genomes or some semblance of stability and nothing else.
There are between 7000 to estimated 15000 genetic diseases in the human tribe.  Here is a good quote for you:

"With this array of human diseases that are caused by mutations, what of positive effects? With thousands of examples of harmful mutations readily available, surely it should be possible to describe some positive mutations if macroevolution is true.

These would be needed not only for evolution to greater complexity, but also to offset the downward pull of the many harmful mutations. But, when it comes to identifying positive mutations, evolutionary scientists are strangely silent."

These religious believers will resort back to the fossils and fantasy of belief. When DNA is absolutely irrefutable physical evidence against all this human garbage religion of Evodelusionism.  You would think that humans are smarter than that?  But they are not.  Human stupidness has no limits. 


Title: Re: PEER REVIEWED AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Sep 3rd, 2011 at 5:29am
Now go listen to my video on DNA Mutations and understand that the only pathway we have is gene loss, if we don't work towards fixing and removing all the mutagens we have now. Humans are degrading faster than ever.
GoodScienceForYou 2 weeks ago 3
Pathoadaptive mutations: gene loss
and variation in bacterial pathogens
google it
GoodScienceForYou 2 weeks ago 3
Gene Loss and Movement in the Maize Genome
Google it.
GoodScienceForYou 2 weeks ago 2
Comparative Genomics of Brassica oleracea and Arabidopsis thaliana Reveal Gene Loss, Fragmentation, and Dispersal after Polyploidy
Google it.
GoodScienceForYou 2 weeks ago 2
Gene Loss and Evolutionary Rates Following Whole-Genome Duplication in Teleost Fishes
Google it.
GoodScienceForYou 2 weeks ago
Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma
Google it.
GoodScienceForYou 2 weeks ago
For about 150 years people have been making this Evodelusion religion to be real. In the mean time we found DNA. DNA is the only real evidence we have, and it only shows genetic degradation of all multicellular creatures.
GoodScienceForYou 2 weeks ago
Evolution of mitochondrial gene content: gene loss and transfer to the nucleus
Google it.
GoodScienceForYou 2 weeks ago
When less is more: gene loss as an engine of evolutionary change.
Google it.
This is funny. Gene loss means less able to adapt, less fit, and the environment and foods are far more restricted,
GoodScienceForYou 2 weeks ago
Gene Loss, Protein Sequence Divergence, Gene Dispensability, Expression Level, and Interactivity Are Correlated in Eukaryotic Evolution
Google it.
GoodScienceForYou 2 weeks ago
Up-regulation of hypoxia-inducible factors HIF-1α and HIF-2α under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function
Google it.
GoodScienceForYou 2 weeks ago
EST Analysis of the Cnidarian Acropora millepora Reveals Extensive Gene Loss and Rapid Sequence Divergence in the Model Invertebrates
Google it.
GoodScienceForYou 2 weeks ago
Multiple rounds of speciation associated with reciprocal gene loss in polyploid yeasts.
Google it.
GoodScienceForYou 2 weeks ago
Genetics of gene expression surveyed in maize, mouse and man
Google it.
GoodScienceForYou 2 weeks ago
Dissecting Arabidopsis thaliana DICER function in
small RNA processing, gene silencing and DNA
methylation patterning
Google it.
GoodScienceForYou 2 weeks ago
A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer.
google it.
GoodScienceForYou 2 weeks ago
S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function
There are over 88,000 peer reviewed articles on gene loss alone.
GoodScienceForYou 2 weeks ago
Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing
Google it.
Do independent research and understand what is going on.
GoodScienceForYou 2 weeks ago
A System of Shuttle Vectors and Yeast Host Strains Designed for Efficient Manipulation of DNA in Saccharomyces cerevisiae
google it.
GoodScienceForYou 2 weeks ago
Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation
Google it.
GoodScienceForYou 2 weeks ago
Comparable Rates of Gene Loss and Functional Divergence After Genome Duplications Early in Vertebrate Evolution
google it.
GoodScienceForYou 2 weeks ago
There is only gene loss, atrophy, genetic weakness, in any form of mutation as a result.
GoodScienceForYou 2 weeks ago
Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer
Google it.
GoodScienceForYou 2 weeks ago
Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer
Google it.
GoodScienceForYou 2 weeks ago
Respiratory deficiency due to loss of mitochondrial DNA in yeast lacking the frataxin homologue
Google it.
GoodScienceForYou 2 weeks ago
Genetics 1651.short
google it.
GoodScienceForYou 2 weeks ago
Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma 9700.short
google it
GoodScienceForYou 2 weeks ago
S016895259901971X
Google it
GoodScienceForYou 2 weeks ago
SmithFJDetal.1743.pdf
Google it
GoodScienceForYou 2 weeks ago
it's funny because there is no difference between micro and macro evolution. Scientists don't recognize separate terms for the two. Creationists want to say that micro evolution can happen but macro not? That's wrong, because basically macro evolution, is micro evolution happening 1,000,000 times to produce something totally different.
Sanquinity 2 weeks ago
@Sanquinity The reality is that what is produced is reduced in fitness from the ancestor. There is only genetic degradation shown in absolutely irrefutable DNA evidence. In all cases multicellular creatures lose gene, have less fit genes, and have just plain genetic diseases as time go on.
Evolution is not science.
GoodScienceForYou 2 weeks ago
@GoodScienceForYou Um, wrong. Mutations is not the same thing as traits. Though mutations can become traits over time. Traits are the things that set us apart. Hair colour, eye colour, skin colour, ect. Mutations would be babies born without a limb, with a bulge not supposed to be there on their body, act. Traits is what evolution is about, mutations is something different. Still, some rare mutations can be a good thing.
Sanquinity 2 weeks ago
@Sanquinity You are a fool. There is only genetic loss, and de-evolution shown in all complex creatures. They lose features and become less and less able to adapt. Then extinction is the norm. Study real science and real genetics. Evolution is nonsense.
GoodScienceForYou 2 weeks ago
@GoodScienceForYou No, YOU study real science and real genetics. We, as a species of ape (not monkey) are the evidence of evolution, f**kING WORKING. You just ignore the scientific facts and only see what you want to see.
Sanquinity 2 weeks ago
@Sanquinity you are a fool. I pity people so gullible as to believe the religious nonsense of Evotards.
Humans and Apes are de-evolved from a far superior creature.
GoodScienceForYou 2 weeks ago
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AlanCFA 2 days ago
@Sanquinity You are a brainwashed fool. Did anybody ever tell you that getting all your information from the people who indoctrinated you is a cult.
If you want to learn about humanity you need to get away from them and study humanity and all their nonsense from a distance. Emotional controls of society are horrible things.
GoodScienceForYou 2 weeks ago
@GoodScienceForYou If I was even indoctrinated, it was by Christians. I was raised a Christian, then at age 15, now 9 years ago, I started to think for myself and research/explore for myself. I was never indoctrinated in the ways of evolution, I came to my own conclusions. And I have yet to see proper evidence that goes against it.
Sanquinity 2 weeks ago
@Sanquinity Yea! Right! and at your age you are full of wisdom. garbage, I'll bet you can't even wipe your ass correctly. There is no evidence for evolution. The ONLY real evidence we have is DNA. And DNA only shows gene loss with speciation. If you were to look you will see the same thing.
GoodScienceForYou 2 weeks ago
@GoodScienceForYou Right, and you as a...non-evolutionist know so much better than the scientists that have spent years upon years of study, research, tests and god knows what else to get to their conclusion. What do you have? Some obscure sites that try (only TRY) to disprove evolution, but don't have any actual evidence? I'd rather believe in the scientists than in you, thank you very much.
Sanquinity 2 weeks ago
@Sanquinity I am a scientist. I have been studying this for over 43 years and have read over 27,000 peer papers on this. The only thing shown is reduction in fitness. Humans now have over 4500 genetic diseases from "evolution". The experts can only show me 4 positive mutations. That is 1100 to 1 for genetic degradation only.
GoodScienceForYou 2 weeks ago
@GoodScienceForYou You're a scientist...right, sorry if I don't believe someone over the internet, posting in a youtube comment section, saying they're a scientist.
Sanquinity 2 weeks ago
@Sanquinity Why would you believe some moron with a PHD? I want you to wake up about human folly. People believe in Evolution because they don't want the truth that they are destroying their species, by what they do.
GoodScienceForYou 2 weeks ago
@GoodScienceForYou "Why would you believe some moron with a PHD?" You keep claiming that a psychologist with a PhD tested your IQ and you expect that to lend credibility to your ludicrous claim. I don't believe your story, but if it were true, that would be one PhD. The theory of evolution is supported by nearly every biologist with a PhD - only a few YECs like you deny the theory.
AlanCFA 2 days ago
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GoodScienceForYou 1 day ago
@Sanquinity I have to go to bed now. I live in Holland.
GoodScienceForYou 2 weeks ago
@GoodScienceForYou I live in the netherlands too. And hey, I agree that we are de-evolving right now. We're making our own species weaker by allowing all kinds of people procreate that are degrading to our species. Retards, people with mutations, just plain stupid people, gullible people, people with inherit genetic defects, you name it. They're all allowed to procreate, which makes our species weaker. But evolution as a whole, works.
Sanquinity 2 weeks ago
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GoodScienceForYou 2 weeks ago
@GSFY "I am a scientist." That is a lie. You sell hot tubs.
"I have been studying this for over 43 years and have read over 27,000 peer papers on this" More lies. You do not even know the basic principles of science or the theory of evolution. You claimed two years ago to have read 20,000 papers, then 200,000 with 20,000 "in-depth". You've been asked what SPECIFIC items you disagreed with in published papers and NEVER replied with anything. You can't remember with your photographic memory?
AlanCFA 2 days ago
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@AlanCFA The evidence is overwhelming showing only genetic degradation. The papers you pointed out only show opinions. When DNA is the only source of absolutely irrefutable physical evidence, then all the other evidence must be looked at and it must fit the DNA. It does when you stop believing in fairy tales. There are no organic structures that can fix themselves and make their genome better after a mutation has taken away good cell replication and replaced it with "sick" or weak cells.
GoodScienceForYou 1 day ago
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@AlanCFA I told you before the only evidence that counts is physical, obvious, having no opinions in it. Opinions are like asses, everybody has one and they don't put out anything but human waste.
You don't understand what absolutely irrefutable physical evidence is. In all cases the genomes do not improve become more complex no do they gain in fitness for any environment. Speciation causes genetic losses.
GoodScienceForYou 1 day ago 2
@Sanquinity I don't have any beliefs. I only go with the evidence. We have only had DNA for about 30 years and it wasn't until the last 10 that they have done much with it. DNA is the only irrefutable, physical, evidence we have, and it only shows genetic losses and genetic degradation less fitness, less able to adapt and then extinction if the degradation is not stopped.
GoodScienceForYou 2 weeks ago
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AlanCFA 2 days ago
@GoodScienceForYou "There is no evidence for evolution" Liar
"The ONLY real evidence we have is DNA.

Title: Re: PEER REVIEWED AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Nov 1st, 2012 at 1:14am
Human amniotic fluid stem cells as a model for functional studies of genes involved in human genetic diseases or oncogenesis
Margit Rosner, Helmut Dolznig, Katharina Schipany, Mario Mikula, Oliver Brandau, Markus Hengstschläger
Oncotarget. 2011 September; 2(9): 705–712. Published online 2011 September 14.
PMCID: PMC3248217

Title: Re: PEER REVIEWED AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Nov 1st, 2012 at 1:18am
http://www.plosgenetics.org/article/info%3Adoi/10.1371/journal.pgen.1002607

Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals
Zari Dastani, Marie-France Hivert, Nicholas Timpson, John R. B. Perry, Xin Yuan, Robert A. Scott, Peter Henneman, Iris M. Heid, Jorge R. Kizer, Leo-Pekka Lyytikäinen, Christian Fuchsberger, Toshiko Tanaka, Andrew P. Morris, Kerrin Small, Aaron Isaacs, Marian Beekman, Stefan Coassin, Kurt Lohman, Lu Qi, Stavroula Kanoni, James S. Pankow, Hae-Won Uh, Ying Wu, Aurelian Bidulescu, Laura J. Rasmussen-Torvik, Celia M. T. Greenwood, Martin Ladouceur, Jonna Grimsby, Alisa K. Manning, Ching-Ti Liu, Jaspal Kooner, Vincent E. Mooser, Peter Vollenweider, Karen A. Kapur, John Chambers, Nicholas J. Wareham, Claudia Langenberg, Rune Frants, Ko Willems-vanDijk, Ben A. Oostra, Sara M. Willems, Claudia Lamina, Thomas W. Winkler, Bruce M. Psaty, Russell P. Tracy, Jennifer Brody, Ida Chen, Jorma Viikari, Mika Kähönen, Peter P. Pramstaller, David M. Evans, Beate St. Pourcain, Naveed Sattar, Andrew R. Wood, Stefania Bandinelli, Olga D. Carlson, Josephine M. Egan, Stefan Böhringer, Diana van Heemst, Lyudmyla Kedenko, Kati Kristiansson, Marja-Liisa Nuotio, Britt-Marie Loo, Tamara Harris, Melissa Garcia, Alka Kanaya, Margot Haun, Norman Klopp, H.-Erich Wichmann, Panos Deloukas, Efi Katsareli, David J. Couper, Bruce B. Duncan, Margreet Kloppenburg, Linda S. Adair, Judith B. Borja, DIAGRAM+ Consortium, MAGIC Consortium, GLGC Investigators, MuTHER Consortium, James G. Wilson, Solomon Musani, Xiuqing Guo, Toby Johnson, Robert Semple, Tanya M. Teslovich, Matthew A. Allison, Susan Redline, Sarah G. Buxbaum, Karen L. Mohlke, Ingrid Meulenbelt, Christie M. Ballantyne, George V. Dedoussis, Frank B. Hu, Yongmei Liu, Bernhard Paulweber, Timothy D. Spector, P. Eline Slagboom, Luigi Ferrucci, Antti Jula, Markus Perola, Olli Raitakari, Jose C. Florez, Veikko Salomaa, Johan G. Eriksson, Timothy M. Frayling, Andrew A. Hicks, Terho Lehtimäki, George Davey Smith, David S. Siscovick, Florian Kronenberg, Cornelia van Duijn, Ruth J. F. Loos, Dawn M. Waterworth, James B. Meigs, Josee Dupuis, J. Brent Richards
PLoS Genet. 2012 March; 8(3): e1002607. Published online 2012 March 29. doi: 10.1371/journal.pgen.1002607
PMCID: PMC3315470

Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P=4.5×10−8–1.2×10−43). Using a novel method to combine data across ethnicities (N=4,232 African Americans, N=1,776 Asians, and N=29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 genes at candidate regions were associated with adiponectin concentrations after accounting for multiple testing (p<3×10−4). We next developed a multi-SNP genotypic risk score to test the association of adiponectin decreasing risk alleles on metabolic traits and diseases using consortia-level meta-analytic data. This risk score was associated with increased risk of T2D (p=4.3×10−3, n=22,044), increased triglycerides (p=2.6×10−14, n=93,440), increased waist-to-hip ratio (p=1.8×10−5, n=77,167), increased glucose two hours post oral glucose tolerance testing (p=4.4×10−3, n=15,234), increased fasting insulin (p=0.015, n=48,238), but with lower in HDL-cholesterol concentrations (p=4.5×10−13, n=96,748) and decreased BMI (p=1.4×10−4, n=121,335). These findings identify novel genetic determinants of adiponectin levels, which, taken together, influence risk of T2D and markers of insulin resistance.

Title: Re: PEER REVIEWED AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Nov 1st, 2012 at 2:01am
Am J Hum Genet. 2010 June 11; 86(6): 904–917.
doi:  10.1016/j.ajhg.2010.05.005
PMCID: PMC3032075
Principal-Component Analysis for Assessment of Population Stratification in Mitochondrial Medical Genetics

Alessandro Biffi,1,2,3,9 Christopher D. Anderson,1,2,3,9 Michael A. Nalls,4,9 Rosanna Rahman,1,2,3 Akshata Sonni,1,2,3 Lynelle Cortellini,1,2,3 Natalia S. Rost,1,2,3 Mar Matarin,4,5 Dena G. Hernandez,4,6 Anna Plourde,1,2,3 Paul I.W. de Bakker,3,7 Owen A. Ross,8 Steven M. Greenberg,2 Karen L. Furie,2 James F. Meschia,8 Andrew B. Singleton,4 Richa Saxena,1,3 and Jonathan Rosand1,2,3,
Author information ► Article notes ► Copyright and License information ►
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Abstract
Although inherited mitochondrial genetic variation can cause human disease, no validated methods exist for control of confounding due to mitochondrial population stratification (PS). We sought to identify a reliable method for PS assessment in mitochondrial medical genetics. We analyzed mitochondrial SNP data from 1513 European American individuals concomitantly genotyped with the use of a previously validated panel of 144 mitochondrial markers as well as the Affymetrix 6.0 (n = 432), Illumina 610-Quad (n = 458), or Illumina 660 (n = 623) platforms. Additional analyses were performed in 938 participants in the Human Genome Diversity Panel (HGDP) (Illumina 650). We compared the following methods for controlling for PS: haplogroup-stratified analyses, mitochondrial principal-component analysis (PCA), and combined autosomal-mitochondrial PCA. We computed mitochondrial genomic inflation factors (mtGIFs) and test statistics for simulated case-control and continuous phenotypes (10,000 simulations each) with varying degrees of correlation with mitochondrial ancestry. Results were then compared across adjustment methods. We also calculated power for discovery of true associations under each method, using a simulation approach. Mitochondrial PCA recapitulated haplogroup information, but haplogroup-stratified analyses were inferior to mitochondrial PCA in controlling for PS. Correlation between nuclear and mitochondrial principal components (PCs) was very limited. Adjustment for nuclear PCs had no effect on mitochondrial analysis of simulated phenotypes. Mitochondrial PCA performed with the use of data from commercially available genome-wide arrays correlated strongly with PCA performed with the use of an exhaustive mitochondrial marker panel. Finally, we demonstrate, through simulation, no loss in power for detection of true associations with the use of mitochondrial PCA.

Title: Re: PEER REVIEWED AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Nov 1st, 2012 at 2:02am
Report on the 6th African Society of Human Genetics (AfSHG) Meeting, March 12–15, 2009, Yaoundé, Cameroon
Giorgio Sirugo, Scott M. Williams, Charmaine D. M. Royal, Melanie J. Newport, Branwen J. Hennig, Renato Mariani-Costantini, Franco M. Buonaguro, Digna R. Velez Edwards, Muntaser Ibrahim, Himla Soodyall, Ambroise Wonkam, Raj Ramesar, Charles N. Rotimi
Am J Trop Med Hyg. 2010 August 5; 83(2): 226–229. doi: 10.4269/ajtmh.2010.10-0208
PMCID: PMC2911163

Title: Re: PEER REVIEWED AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Nov 1st, 2012 at 2:04am
How to Catch All Those Mutations—The Report of the Third Human Variome Project Meeting, UNESCO Paris, May 2010
Maija R.J. Kohonen-Corish, Jumana Y. Al-Aama, Arleen D. Auerbach, Myles Axton, Carol Isaacson Barash, Inge Bernstein, Christophe Béroud, John Burn, Fiona Cunningham, Garry R. Cutting, Johan T. den Dunnen, Marc S. Greenblatt, Jim Kaput, Michael Katz, Annika Lindblom, Finlay Macrae, Donna Maglott, Gabriela Möslein, Sue Povey, Raj Ramesar, Sue Richards, Daniela Seminara, María-Jesús Sobrido, Sean Tavtigian, Graham Taylor, Mauno Vihinen, Ingrid Winship, Richard G.H. Cotton, Contributors to the Human Variome Project Meeting
Hum Mutat. Author manuscript; available in PMC 2011 December 1.
Published in final edited form as: Hum Mutat. 2010 December; 31(12): 1374–1381. doi: 10.1002/humu.21379
PMCID: PMC3119486

Title: Re: PEER REVIEWED AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Nov 1st, 2012 at 2:09am
The long-term clinical implications of clonal chromosomal abnormalities in newly diagnosed chronic phase chronic myeloid leukemia patients treated with imatinib mesylate.
Lee SE, Choi SY, Bang JH, Kim SH, Jang EJ, Byeun JY, Park JE, Jeon HR, Oh YJ, Kim M, Kim DW.
Cancer Genet. 2012 Oct 27. doi:pii: S2210-7762(12)00234-7. 10.1016/j.cancergen.2012.09.003.

p38 (MAPK) stress signalling in replicative senescence in fibroblasts from progeroid and genomic instability syndromes.
Tivey HS, Brook AJ, Rokicki MJ, Kipling D, Davis T.
Biogerontology. 2012 Oct 31. [Epub ahead of print]
PMID: 23112078

Title: Re: PEER REVIEWED AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Nov 1st, 2012 at 2:26am
DDX5 is a positive regulator of oncogenic NOTCH1 signaling in T cell acute lymphoblastic leukemia.
Lin S, Tian L, Shen H, Gu Y, Li JL, Chen Z, Sun X, James You M, Wu L.
Oncogene. 2012 Oct 29. doi: 10.1038/onc.2012.482. [Epub ahead of print]
PMID: 23108395

Title: Re: PEER REVIEWED AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Nov 1st, 2012 at 2:27am
Research and clinical applications of cancer genome sequencing.
Ku CS, Cooper DN, E Ziogas D, Halkia E, Tzaphlidou M, Roukos DH.
Curr Opin Obstet Gynecol. 2012 Oct 26. [Epub ahead of print]
PMID: 23108289

Title: Re: PEER REVIEWED AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Nov 1st, 2012 at 2:54am
Lack of association between genetic polymorphisms within KCNQ1 locus and type 2 diabetes in Tunisian Arabs.
Turki A, Mtiraoui N, Al-Busaidi AS, Khirallah M, Mahjoub T, Almawi WY.
Diabetes Res Clin Pract. 2012 Oct 26. doi:pii: S0168-8227(12)00373-7. 10.1016/j.diabres.2012.10.006.

Title: Re: PEER REVIEWED AlanCFAs idea of evidence for evolution
Post by GoodScienceForYou on Nov 1st, 2012 at 2:56am
Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes.
Gallo ML, O'Hara AJ, Rudd ML, Urick ME, Hansen NF, O'Neil NJ, Price JC, Zhang S, England BM, Godwin AK, Sgroi DC; NIH Intramural Sequencing Center (NISC) Comparative Sequencing Program, Hieter P, Mullikin JC, Merino MJ, Bell DW.
Nat Genet. 2012 Oct 28. doi: 10.1038/ng.2455.

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