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DNA Mutations. (Read 12481 times)
GoodScienceForYou
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The obvious isn't obvious
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DNA Mutations.
Mar 13th, 2011 at 6:23pm
 
H L Mencken:
" The way to deal with superstition is not to be polite to it, but to tackle it with all arms, and so rout it, cripple it, and make it forever infamous and ridiculous "

While you are here, you can visit my music page and listen to some of the classic style of blues made modern. 
http://www.soundclick.com/havenhead

Evolution is a mythological religion with no physical evidence.
All the physical evidence we have NOW, not in the past, disproves that any creature has ever become more complex, more intelligent.  All are showing signs of genetic decay, as time goes on. 


Mutations are changes to DNA. They are not genetic information that is transferred between generations from the DNA of the parents.  Mutation means changes that cause the formatoin of ONLY new gentic proteans and body structures.

When you start a deep study of the human genome, you will realize that we are not evolving.  We are de-evolving, losing genetic coding, and having mutations that are basically making us weaker and less intelligent. 


According to the believers in evolution (modern mythology), who have a vested monetary interest in keeping this mythology going, they have to admit that "70%" of mutations are harmful, negative, deleterious to the genome.  29% are considered neutral, and 1% might be positive.  This is a very conservative admission.  It is more like 90% is lowering the effectiveness of our cells to continue to make healthy people.  As a species we are no where near as healthy as we once were. The evidence of this is in our genomes, the coding of our bodies shown in the DNA.

That is 70 to 1 odds against us.  If we did not have (designed in) built in, genetic mechanisms that repair cells constantly and our reproductive mechanism that stops somatic cells from destroying germ cells.  In this the somatic cells normally do no affect the germ cells. But even so, nothing can stop the genetic degradation except for us to stop destroying our genomes with toxins of modern life.

For example, they finally figured out that mammograms cause cancer.  When you radiate the most sensitive soft tissue you can expect the cells to mutate into cancer.  There was a tiny report in the news about this and I expect that this will "just go away" until we have an epidemic of cancers caused by testing for cancer. Radiation is the NUMBER ONE cause of cancer mutations.

The genome has "parent coding" or master coding that directs where body parts are placed, called Hox genes.  If these are effected by mutations at the time of conception or before birth, then you get some bad results.  Siamese twins, Hermaphroditus, tails, or born dead with organs that do not function for life. The parts of the body are not made correctly or they are in the wrong place.

Somatic mutations are acquired during life and are not in the sexual genetics so they are not, normally, passed on to offspring.  (Thank God for this.)
This is one of the reasons why we were made with women having all their egg cells made at birth, insuring the best possible eggs.  This is genetic engineering from God is to preserve us from our failings but only to the degree that we can. There is still genetic mutations passed down over time that are detrimental.  As time goes on we are constantly degrading far more than any possibility of any "positive" mutations to be able to correct anything.

What I am talking about is serious and affects our descendants. If you don't want your descendants to suffer, have short lives, and be mentally retarded any farther than we are now, then you must pay attention. More later.



http://ghr.nlm.nih.gov/handbook/mutationsanddisorders/genemutation
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GoodScienceForYou
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Re: DNA Mutations.
Reply #1 - Mar 20th, 2011 at 4:02pm
 
Nut cases are arguing with creationists and thinking it is an argument for science.

Creationism VS Evodelusionism is not an argument.

Creationism VS Evodelusionism is not an argument.

Creationism VS Evodelusionism is not an argument.

Creationism VS Evodelusionism is not an argument.....................................

There is no science in delusions.

DNA evidence is absolutely irrefutable physical evidence that evolution has never taken place.

There are no improvements shown in any DNA study, only continual degradation of the genomes.

If you don't understand that, it is because you are ignorant, brainwashed, religious nut case.

The Chimp, Gorilla, Orangutan, Macaque are all from the same genetic lineage as humans.  This is clearly in the DNA evidence. All have degraded genetically over the many years.  They have not improved. Neither have humans.

If you want to see what happens to the human genome when radiation and lifestyle eats away at the cell replication and destroys the DNA sequences that produce healthy cells, look at the chimp, gorilla, orangutan,and macaque. Tremendous genetic losses are shown in these creatures because they lived in volcanic regions with high levels of natural radiation.


There is no "magical mutations" that fixes screwed up genomics.  70% of the mutations are bad, deleterious and
29% are considered neutral with 1% "Might be" helpful.

There is no net evolution towards more fit, more complex, nor more healthy.  All creatures are heading towards extinction, the natural result of diminished genetic coding.

The best we can do is to preserve our genome so that our descendants are not unintelligent retards scraping the ground for food until the entire species dies out.

Chimps, Gorillas, Orangutans are all going extinct. They do not have the skills, nor health, necessary to survive much longer. The message is clear in the DNA and what has happened to them is a message for us.

They have diabetes, heart disease, cancer, shortening lifespan and many of the illnesses we are  rapidly progressing towards as our genome is being destroyed by constant electromagnetic radiation, bad lifestyles and not using much of our existing survival genetics. 

Don't be stupid and believe in magical nonsense. Follow the evidence. It is clear, cannot be denied, unless you  keep your head in the sand of ridiculous beliefs having no foundation other than your religious mythology.   

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GoodScienceForYou
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Re: DNA Mutations.
Reply #2 - Apr 6th, 2011 at 3:36pm
 
ProofMan wrote on Apr 5th, 2011 at 2:19am:
Quote:
This is genetic engineering from God

Questioning Questioning Questioning

Good question.

There is only one God.  God = Truth
God <=> Religion

(<=> means "NOT EQUAL TO")

When people give up religious ideology, mumbo jumbo emotionalism, worthless ritualisms and idols of icons, and just follow the Truth, God becomes clearer and clearer until you attain the knowledge of God.

First clue towards the truth.  There are no paid priests of the Truth.  The Truth is never a money maker.  The Truth is wonderful and is great.  The truth is not popular so it doesn't make money.

"My religion consists of a humble admiration of the illimitable superior spirit who reveals himself in the slight details we are able to perceive with our frail and feeble mind." Albert Einstein

People who are geniuses realize just how stupid they are.  That is the best part of genius.  It forces humility on you.

My Guru used to say; "The mind is a terrible master, but a good slave".
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GoodScienceForYou
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Re: DNA Mutations. Gene loss and Peer Reviewed articles.
Reply #3 - Apr 6th, 2011 at 4:09pm
 
These are quotes from the US government site on genetics.
When something that was working fine and has a mutation, then the odds are 70 to 1 that it is deleterious, according to degreed, PHD's of genetics.
There are mechanisms that repair DNA, (thank God!) but if those mechanisms are screwed up because they are controlled by DNA, then some really bad diseases happen.

Point Mutation
A point mutation is a simple change in one base of the gene sequence. This is equivalent to changing one letter in a sentence, such as this example, where we change the 'c' in cat to an 'h':

Original

The fat cat ate the wee rat.

Point Mutation      The fat hat ate the wee rat.
(Sickle Cell Anemia is a point mutation that modified one base pair.)

Frame-shift mutation
Frame-shift mutations. In a frame shift mutation, one or more bases are inserted or deleted, the equivalent of adding or removing letters in a sentence. But because our cells read DNA in three letter "words", adding or removing one letter changes each subsequent word. This type of mutation can make the DNA meaningless and often results in a shortened protein. An example of a frame-shift mutation using our sample sentence is when the 't' from cat is removed, but we keep the original letter spacing:

Original

The fat cat ate the wee rat.

Frame Shift      The fat caa tet hew eer at.

(Frame shift is horrible for any complex creature with multi-cells. For bacteria,(single cell creatures) for instance, it either kills it or it lives to eat more carbon based foods.)

Deletion
Mutations that result in missing DNA are called deletions. These can be small, such as the removal of just one "word," or longer deletions that affect a large number of genes on the chromosome. Deletions can also cause frameshift mutations. In this example, the deletion eliminated the word cat.

Original

The fat cat ate the wee rat.

Deletion      The fat ate the wee rat.
( Consider that you need that protean to make cells which make body parts. When the codon is gone, there is no protean being produced.)

Insertion
Mutations that result in the addition of extra DNA are called insertions. Insertions can also cause frameshift mutations, and general result in a nonfunctional protein.

(NOTE:  "nonfunctional protean".)

Original

The fat cat ate the wee rat.

Insertion      The fat cat xlw ate the wee rat.
Inversion
In an inversion mutation, an entire section of DNA is reversed. A small inversion may involve only a few bases within a gene, while longer inversions involve large regions of a chromosome containing several genes.

Original

The fat cat ate the wee rat.

Insertion      The fat tar eew eht eta tac.
DNA expression mutation
There are many types of mutations that change not the protein itself but where and how much of a protein is made. These types of changes in DNA can result in proteins being made at the wrong time or in the wrong cell type. Changes can also occur that result in too much or too little of the protein being made.

(What part of this is good? Duh!  NONE!)


Here are all the types of mutations from US gov genetics site:
"Missense mutation
This type of mutation is a change in one DNA base pair that results in the substitution of one amino acid for another in the protein made by a gene."

If you have correct cell reproduction, you don't with this. The cell is reduced in its function or it atrophies.


"Nonsense mutation
A nonsense mutation is also a change in one DNA base pair. Instead of substituting one amino acid for another, however, the altered DNA sequence prematurely signals the cell to stop building a protein. This type of mutation results in a shortened protein that may function improperly or not at all."

If you had a good cell replication this certainly will screw it up and cause it to atrophy. You cannot build healthy cells with messed up DNA and short of a needed protean. 


"Insertion
An insertion changes the number of DNA bases in a gene by adding a piece of DNA. As a result, the protein made by the gene may not function properly."

If you have an insertion, the protean that was being made is not made the way it was originally.  This is almost always detrimental.


Deletion
A deletion changes the number of DNA bases by removing a piece of DNA. Small deletions may remove one or a few base pairs within a gene, while larger deletions can remove an entire gene or several neighboring genes. The deleted DNA may alter the function of the resulting protein(s)."

If you delete the proper coding for say a lung cell, what do you think will happen?  It diminishes in its function and has a "genetic disease".  Normal cell reproduction is reduced or completely flawed.


"Duplication

A duplication consists of a piece of DNA that is abnormally copied one or more times. This type of mutation may alter the function of the resulting protein."

This is sometimes neutral, but most of the time harmful because you have an extra protean that is not needed.


"Frameshift mutation

This type of mutation occurs when the addition or loss of DNA bases changes a gene’s reading frame. A reading frame consists of groups of 3 bases that each code for one amino acid. A frameshift mutation shifts the grouping of these bases and changes the code for amino acids. The resulting protein is usually nonfunctional. Insertions, deletions, and duplications can all be frameshift mutations."

Frameshifts are almost always harmful to cell reproduction.


Repeat expansion (illustration)
Nucleotide repeats are short DNA sequences that are repeated a number of times in a row. For example, a trinucleotide repeat is made up of 3-base-pair sequences, and a tetranucleotide repeat is made up of 4-base-pair sequences. A repeat expansion is a mutation that increases the number of times that the short DNA sequence is repeated. This type of mutation can cause the resulting protein to function improperly.

Any sane person can see that mutations are not something we want.

We just want our cells to replicate as strong good performing cells, giving us health. But as we progress along the path of self destruction, we are not getting that. There are over 4000 and counting defective DNA codings we have identified so far according the the "Human Genome Project's" head honcho.

The news is not good for humanity.  Self destruction is what we seem to want in our ignorance. 

I am trying very hard to stop this delusional idea that by "magic" our genome will fix all the defects and genetic illnesses.  That is not going to happen without some serious help from the "genetic engineer" who designed us.

We can stop much of it by reducing the causes for the levels of genetic defects we have now.  Continue to interbreed out some of the defects with others who have healthy "complimentary" parts to our defects and pair up with those who are stronger in areas where we are weak.

http://www.ncbi.nlm.nih.gov/pubmed?term=Gene%20loss
There are over 85,000 papers just on gene loss and disease on this PubMed site.
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