GoodScienceForYou
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The obvious isn't obvious until it is obvious
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@GoodScienceForYou "DNA is absolutely irrefutable obvious, clear, concise exacting, not deniable, physical evidence that only shows genetic losses in all complex creatures." Citation needed. TheDcac 4 days ago 2 When I say citation I mean peer reviewed, expert evidence from a well known scientific journal; one such journal might be the International Journal of Biological Sciences. TheDcac 4 days ago 2 @TheDcac Gene loss, protein sequence divergence, gene dispensability, expression level, and interactivity are correlated in eukaryotic evolution. Krylov DM, Wolf YI, Rogozin IB, Koonin EV. Source National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA. GoodScienceForYou 4 days ago @TheDcac Goto PubMed and look up "gene loss". There are hundreds of articles on the nature of gene loss and "evolution". Over 90,000 of them. Goto the Human Genome Project and look up the numbers of genetic defects that have been mapped in humans so far. It is over 4600 now. According to genetic science there are only 4 positive mutations that they "believe" are new. This has been know about for a long time now, since DNA started to be mapped. GoodScienceForYou 4 days ago Am J Med Genet A. 2011 Nov 3. doi: 10.1002/ajmg.a.34302. [Epub ahead of print] Two new cases with microdeletion of 17q23.2 suggest presence of a candidate gene for sensorineural hearing loss within this region. Schönewolf-Greulich B, Ronan A, Ravn K, Baekgaard P, Lodahl M, Nielsen K, Rendtorff ND, Tranebjaerg L, Brøndum-Nielsen K, Tümer Z. Source Genetic Counselling Clinic, Kennedy Center, Glostrup, Denmark. GoodScienceForYou 4 days ago Breast Cancer Res Treat. 2011 Nov 4. [Epub ahead of print] Identification of copy number alterations associated with the progression of DCIS to invasive ductal carcinoma. Johnson CE, Gorringe KL, Thompson ER, Opeskin K, Boyle SE, Wang Y, Hill P, Mann GB, Campbell IG. Source VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Locked Bag 1, A'Beckett St, East Melbourne, Victoria, VIC, 8006, Australia. GoodScienceForYou 4 days ago @GoodScienceForYou None of your spam proves your point. We are all aware of genetic disease. There is a 1 in 200 chance of someone being born with a genetic disease and a 199 in 200 chance that they will not. You stupid war against a well-established scientific theory shows only how your religion has warped your mind. AlanCFA 3 days ago @AlanCFA How many times do I have to post all the data on human odds of genetic diseases, until you understand? Do you not read anything. I put of over 40 posts with the disease and the odds of it taking place. It is greater than 1 to 1 that you have genetic disease or two or even three. You are in denial. It is part of the sickness associated with magical thinking. GoodScienceForYou 3 days ago @GSFY "How many times do I have to post all the data on human odds of genetic diseases, until you understand?" First of all, for the concept of "odds" to make sense, the concept of random MUST exist. You have claimed that it does not. "Do you not read anything. I put of over 40 posts with the disease and the odds of it taking place" Go to the Human Genome website - the odds of someone being born with a single gene disorder 1-in-200. Multiple gene disorders are more rare still. AlanCFA 3 days ago 2 @AlanCFA 1 in 200 is just one disease. Why are you so stupid? Familial hypercholesterolemia 1 in 500 Polycystic kidney disease 1 in 1250 Neurofibromatosis Type I 1 in 2,500 Hereditary spherocytosis 1 in 5,000 Marfan syndrome 1 in 4,000 [2] Huntington's disease 1 in 15,000 [3 GoodScienceForYou 3 days ago Duchenne muscular dystrophy 1 in 7,000 Hemophilia 1 in 10,000 This list is just the "single gene disorders". GoodScienceForYou 3 days ago This has been flagged as spam show AlanCFA 3 days ago There are 173719 papers on human genetic disorders on pubmed site. GoodScienceForYou 3 days ago 1 in 14 have diabetes a genetic disease. GoodScienceForYou 3 days ago Comment removed AlanCFA 3 days ago @GoodScienceForYou "1 in 200 is just one disease. " No - it is the odds of getting ANY of the diseases that you mention. 199 of 200 births do NOT have a single-gene disorder. Multiple-gene disorders are even more rare. Why are you so stupid? AlanCFA 3 days ago 2 @AlanCFA Sickle cell anemia 1 in 625 (African Americans) Cystic fibrosis 1 in 2,000 (Caucasians) Lysosomal Acid Lipase (LAL) Deficiency 1 in 40,000 Tay-Sachs disease 1 in 3,000 (American Jews) Phenylketonuria 1 in 12,000 Mucopolysaccharidoses 1 in 25,000 Glycogen storage diseases 1 in 50,000 Galactosemia 1 in 57,000 GoodScienceForYou 3 days ago @GoodScienceForYou "Sickle cell anemia 1 in 625..." Yes - you are proving what I said, all of the stats that you show are that the odds of getting a genetic disease are LOW. Or do you think that 1 in 625 means that everybody gets sickle cell? From the Human Genome site: "There are more than 6,000 known single-gene disorders, which occur in about 1 out of every 200 births. " And the multiple-gene disorders are even more rare. AlanCFA 3 days ago 2 @AlanCFA You moron! Geeze! You are so stupid! You look at all the numbers and combine them to equal greater than 1 in 1 of you having a genetic defect that will cause you to suffer. You are one dumb person. GoodScienceForYou 3 days ago This has been flagged as spam show AlanCFA 3 days ago @GoodScienceForYou Out of 100 people 100 people will have a genetic disorder(s). Out of 1000 people, 1000 will have a genetic disorder(s). Out of 10000, 10000 will have a genetic disorder(s). Get it. You combine all the numbers and your odds of being sick from a genetic defect are 100% The odds of you having 2 disorders is just as bad. Three is common. This does not include all the babies who die from genetic defects in the womb. Only covers the live births. /watch?v=abcsZZ9Duxw GoodScienceForYou 3 days ago @GoodScienceForYou "You combine all the numbers and your odds of being sick from a genetic defect are 100%" It is when you "combine all the numbers" that the odds are 1 in 200, NOT 1 in 1. Again, this is from the Human Genome website: "There are more than 6,000 known single-gene disorders, which occur in about 1 out of every 200 births." That is a DIRECT QUOTE. Get it through your head, you are WRONG. You rely on your religious indoctrination to try and disprove science. AlanCFA 2 days ago 3 @AlanCFA 1 of Many/ The odds of diabetes is 26,000,000 out of 320,000,000 which is easy to calculate and this is just one genetic disease. 1 in 12 persons in the USA. You take a single point disease and call that ALL the disseases? You are a liar as usual. multifactorial inheritance include: heart disease, high blood pressure, Alzheimer's disease, arthritis, diabetes, cancer, and obesity. Next comes: Chromosome abnormalities, Mitochondrial inheritance Mental Disorders GoodScienceForYou 13 hours ago 2 of Many / Autosomal dominant Familial hypercholesterolemia 1 in 500 Polycystic kidney disease 1 in 1250 Neurofibromatosis Type I 1 in 2,500 Hereditary spherocytosis 1 in 5,000 Marfan syndrome 1 in 4,000 [2] Huntington's disease 1 in 15,000 [3] Autosomal recessive Sickle cell anemia 1 in 625 (African Americans) Cystic fibrosis 1 in 2,000 (Caucasians) Lysosomal Acid Lipase (LAL) Deficiency 1 in 40,000 Tay-Sachs disease 1 in 3,000 (American Jews) Phenylketonuria 1 in 12,000 GoodScienceForYou 13 hours ago 3 of Many/ Mucopolysaccharidoses 1 in 25,000 Glycogen storage diseases 1 in 50,000 Galactosemia 1 in 57,000 X-linked Duchenne muscular dystrophy 1 in 7,000 Hemophilia 1 in 10,000 GoodScienceForYou 13 hours ago 4 of Many/ Cancer Breast 1 in 7. Prostrate 1 in 150 , In addition to the mitochondrial myopathies, other examples include: Diabetes mellitus and deafness (DAD) this combination at an early age can be due to mitochondrial disease Diabetes mellitus and deafness can also be found together for other reasons Leber's hereditary optic neuropathy (LHON) visual loss beginning in young adulthood eye disorder (cont) GoodScienceForYou 13 hours ago 5 of Many/ characterized by progressive loss of central vision due to degeneration of the optic nerves and retina Wolff-Parkinson-White syndrome multiple sclerosis-type disease affects 1 in 50,000 people in Finland GoodScienceForYou 13 hours ago 6 of Many/ Leigh syndrome, subacute sclerosing encephalopathy after normal development the disease usually begins late in the first year of life, although onset may occur in adulthood a rapid decline in function occurs and is marked by seizures, altered states of consciousness, dementia, ventilatory failure Neuropathy, ataxia, retinitis pigmentosa, and ptosis (NARP) progressive symptoms as described in the acronym dementia GoodScienceForYou 13 hours ago 7 of Many/ Myoneurogenic gastrointestinal encephalopathy (MNGIE) gastrointestinal pseudo-obstruction neuropathy GoodScienceForYou 13 hours ago 8 of Many Myoclonic Epilepsy with Ragged Red Fibers (MERRF) progressive myoclonic epilepsy "Ragged Red Fibers" – clumps of diseased mitochondria accumulate in the subsarcolemmal region of the muscle fiber and appear as "Ragged Red Fibers" when muscle is stained with modified Gömöri trichrome stain short stature hearing loss lactic acidosis exercise intolerance GoodScienceForYou 13 hours ago 9 of Many / Mitochondrial myopathy, encephalomyopathy, lactic acidosis, stroke-like symptoms (MELAS) mtDNA depletion mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) Nota bene: Conditions such as Friedreich's ataxia can affect the mitochondria, but are not associated with mitochondrial proteins. GoodScienceForYou 13 hours ago @AlanCFA You don't even understand what statistics are. What a moron. Statistics are based on data. Random is based on some magical human emotional mental garbage. What is wrong with your brain? Have you had an IQ test? GoodScienceForYou 3 days ago @GoodScienceForYou "You don't even understand what statistics are. " Yes I do. It is YOU who do not. I have studied the subject, you have not. You invent lies to try and boost your ego and pretend that you are intelligent and have answers when the truth is that you are a delusional moron. AlanCFA 2 days ago 3 @AlanCFA 1 of 3 will die from cancer. You are really stupid. You need to go study this away from your religious crap. The data is all over on the government medical sites, cancer sites, CDC, pub med etc. They have all the statistics from real life, not from your religion. GoodScienceForYou 2 days ago @GoodScienceForYou "1 of 3 will die from cancer." The other 2 of 3 will die of something else. Most cancers are new and not genetically based, so this statement is irrelevant to your claim about genetic degradation. AlanCFA 2 days ago @AlanCFA Statistics are based on evidence also called data. Random mutations are caused by a mental disease called delusions. Delusions are what fuel most people. Random is not a scientific word. Odds based on statistics is a valid part of science using data and applied math. GoodScienceForYou 2 days ago @AlanCFA A single gene disorder is only one type of disorder. Go look at the entire human genome chart. You can get a copy from them for free. It was paid for by your tax dollars. The best thing you could do for your self is to extract yourself from all of your self imposed beliefs not founded in reality. This is just one of those beliefs. Beliefs are based on ideas that give your emotions some sort of relief. The strongest emotion is fear. Those born as C religion are taught fear from birth. GoodScienceForYou 2 days ago @GSFY "A single gene disorder is only one type of disorder" True, there are 4 types of genetic disorders 1) Single gene 2) Multifactorial (also called complex or polygenic) 3) Chromosomal 4) Mitochondrial The odds of getting a single gene disorder are 1-in-200, that is 0.05 of births. The other genetic disorders are LESS LIKELY. So when you add up 0.05 with three numbers that are SMALLER, you do not even get 1-in-100, much less 1-in-1. Your stupid claim is wrong as is your denial of the TOE AlanCFA 2 days ago @AlanCFA "Go to the Human Genome website - the odds of someone being born with a single gene disorder 1-in-200. Multiple gene disorders are more rare still." Yet, every single human I have met has some sickness, some body disorder, or some disease. Have you never talked with anyone? Do you ever pay attention to your own sicknesses? 1 in 14 Now has a form diabetes, which is a genetic weakness. 1 in three die of cancer. 50% of adult Americans are on some form of drug for mental disorders. GoodScienceForYou 2 days ago @GoodScienceForYou "Yet, every single human I have met has some sickness, some body disorder, or some disease." Doesn't say much for the crowd your run with. You claimed that the odds were 1-in-1 and the Human Genome website shows that they are 1-in-200. As to diabetes, the American Diabetes Assn says that genetics alone does not cause diabetes, but genetics plus environment. Type 2 diabetes (adult onset) is fairly common, but is primarily caused by eating and exercise habits - not genetics. AlanCFA 2 days ago @AlanCFA What type of diabetes is not caused by genetic weaknesses? Why are there people with horrible eating habits and who don't exercise at all without diabetes? Duh? Do you know anything about diabetes at all? but "genetics plus environment." You post genetics is the cause with environment? And you say it has nothing to do with genetic weaknesses? You are really living under a rock of ignorance. Try reading what you write instead of being so angry and emotional about your religion. GoodScienceForYou 2 days ago Comment removed GoodScienceForYou 2 days ago @AlanCFA There are epidemics of diabetes in the US and in Europe. This is because of the genetic weaknesses of "modern" mutations. Did you know that "diabetes" runs in families? Duh? How is that possible if diabetes is not a genetic disease? GoodScienceForYou 2 days ago @AlanCFA Let me teach you some math. In the US there are 26,000,000 people with diabetes. There are 312566000 people in the US. Divide each by 26,000,000 and you get the 1 in 12 odds of having diabetes. That is just one disease. Are you able to comprehend? Is anybody home? Do you know about numbers.. Numbers are like this 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10. Can you count? GoodScienceForYou 2 days ago @AlanCFA People are looking to stop the pain and suffering from childhood abuses and often that includes the strong sense of guilt from some well known religions. You think that this crap religion of evolution will set you free. What will set you free is you realizing the Truth and nothing else can do that for you. Jumping from one screwed up religion into another is a common human characteristic. If you want to be free, seek the truth. GoodScienceForYou 2 days ago This has been flagged as spam show AlanCFA 2 days ago 2 @AlanCFA Scientists are also realizing that obesity is also caused by genetic causes. So is mental illness, like you have. Over 50% of adults in the US are taking some sort of drug for mental problems. I think most of those believe in evolution, because it is a depression religion. There is a long list of mental diseases caused by mutations/genetics. GoodScienceForYou 2 days ago @AlanCFA Cancer is caused by the bodies inability to destroy mutant cells with a fully functioning immune system. Cancer cells are a naturally occuring phenomenon. The odds of you having cancer cells is like 100% according to statistics. If you have a healthy immune system (one that is not messed up from incorrect human behavior that would have preserved your genome) your body will destroy the cancer cells as soon as they show up, GoodScienceForYou 2 days ago As people age 1 in 3 will have their immune system fail from weakness first and cause cancer. Why are there people who live to 100 who smoke tobacco, drink, and eat crap? Could it be genetics of a powerful immune system? HMM? If they have an overly powerful immune system they often suffer from auto immune diseases from overly powerful genetically defective immune system. GoodScienceForYou 2 days ago J Cell Mol Med. 2011 Nov 2. doi: 10.1111/j.1582-4934.2011.01483.x. [Epub ahead of print] Inhibition of JAK2/STAT3 signaling induces colorectal cancer cell apoptosis via mitochondrial pathway. Du W, Hong J, Wang YC, Zhang YJ, Wang P, Su WY, Lin YW, Lu R, Zou W, Xiong H, Fang JY. GoodScienceForYou 4 days ago Source From GI Division, Shanghai Jiao-Tong University School of Medicine Renji Hospital, Shanghai Institution of Digestive Disease; Key Laboratory of Gastroenterology & Hepatology, Ministry of Health (Shanghai Jiao-Tong University); State Key Laboratory of Oncogene and Related Genes. 145 Middle Shandong Rd, Shanghai 200001, China. GoodScienceForYou 4 days ago @GSFY "Arterioscler Thromb Vasc Biol 1998 Apr;18(4):562-567. "PAI-1 plasma levels in a general population without clinical evidence of atherosclerosis: relation to environmental and genetic determinants," by Margaglione M, Cappucci G, et al." Question - is this one of the "four" mutations that you claim is positive? What about "Polymorphisms in the coagulation factor VII gene and the risk of myocardial infarction" ? AlanCFA 3 days ago Detection and functional characterization of a large genomic deletion resulting in decreased pathogenicity in Ralstonia solanacearum race 3 biovar 2 strains. González A, Plener L, Restrepo S, Boucher C, Genin S. Environ Microbiol. 2011 Nov 3. doi: 10.1111/j.1462-2920.2011.02636.x. [Epub ahead of print] PMID: 22050636 [PubMed - as supplied by publisher] GoodScienceForYou 4 days ago J Med Genet. 2011 Nov 2. [Epub ahead of print] Disruption of a long distance regulatory region upstream of SOX9 in isolated disorders of sex development. Benko S, Gordon CT, Mallet D, Sreenivasan R, Thauvin-Robinet C, Brendehaug A, Thomas S, Bruland O, David M, Nicolino M, Labalme A, Sanlaville D, Callier P, Malan V, Huet F, Molven A, Dijoud F, Munnich A, Faivre L, Amiel J, Harley V, Houge G, Morel Y, Lyonnet S. Source 1INSERM U-781, Hôpital Necker-Enfants Malades, Paris, France. GoodScienceForYou 4 days ago Loss of UDP-N-acetylglucosamine 2-epimerase/ N-acetylmannosamine kinase (GNE) induces apoptotic processes in pancreatic carcinoma cells. Kemmner W, Kessel P, Sanchez-Ruderisch H, Möller H, Hinderlich S, Schlag PM, Detjen K. FASEB J. 2011 Nov 2. [Epub ahead of print] PMID: 22049060 [PubMed - as supplied by publisher] GoodScienceForYou 4 days ago Basal-like Breast cancer DNA copy number losses identify genes involved in genomic instability, response to therapy, and patient survival. Weigman VJ, Chao HH, Shabalin AA, He X, Parker JS, Nordgard SH, Grushko T, Huo D, Nwachukwu C, Nobel A, Kristensen VN, Børresen-Dale AL, Olopade OI, Perou CM. Breast Cancer Res Treat. 2011 Nov 3. [Epub ahead of print] PMID: 22048815 [PubMed - as supplied by publisher] GoodScienceForYou 4 days ago J Immunol. 2011 Nov 2. [Epub ahead of print] Human Th1 and Th17 Cells Exhibit Epigenetic Stability at Signature Cytokine and Transcription Factor Loci. Cohen CJ, Crome SQ, Macdonald KG, Dai EL, Mager DL, Levings MK. Source Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada; GoodScienceForYou 4 days ago Mol Genet Genomics. 2011 Nov 3. [Epub ahead of print] Structure of the acyl-glucose-dependent anthocyanin 5-O-glucosyltransferase gene in carnations and its disruption by transposable elements in some varieties. Nishizaki Y, Matsuba Y, Okamoto E, Okamura M, Ozeki Y, Sasaki N. Source Department of Biotechnology and Life Science, Faculty of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo, 184-8588, Japan. GoodScienceForYou 4 days ago Chimpanzee_Genome_Project GoodScienceForYou 4 days ago Disruption of Smad4 impairs TGF-β/Smad3 and Smad7 transcriptional regulation during renal inflammation and fibrosis in vivo and in vitro. Meng XM, Huang XR, Xiao J, Chung AC, Qin W, Chen HY, Lan HY. Kidney Int. 2011 Nov 2. doi: 10.1038/ki.2011.327. [Epub ahead of print] PMID: 22048127 [PubMed - as supplied by publisher] GoodScienceForYou 4 days ago Micro RNA -214,-150,-146a and-125b target Huntingtin gene. Sinha M, Ghose J, Bhattarcharyya NP. RNA Biol. 2011 Nov 1;8(6). [Epub ahead of print] PMID: 22048026 [PubMed - as supplied by publisher] GoodScienceForYou 4 days ago Deletion of exon 20 of the familial dysautonomia gene ikbkap in mice causes developmental delay, cardiovascular defects, and early embryonic lethality. Dietrich P, Yue J, E S, Dragatsis I. PLoS One. 2011;6(10):e27015. Epub 2011 Oct 28. PMID: 22046433 [PubMed - in process] GoodScienceForYou 4 days ago This has been flagged as spam show TheDcac 4 days ago Loss of the α2β1 Integrin Alters Human Papilloma Virus-Induced Squamous Carcinoma Progression In Vivo and In Vitro. Tran T, Barlow B, O'Rear L, Jarvis B, Li Z, Dickeson K, Dupont W, Zutter M. PLoS One. 2011;6(10):e26858. Epub 2011 Oct 27. PMID: 22046385 [PubMed - in process] GoodScienceForYou 4 days ago PLoS One. 2011;6(10):e26737. Epub 2011 Oct 26. The CDKN2A G500 Allele Is More Frequent in GBM Patients with No Defined Telomere Maintenance Mechanism Tumors and Is Associated with Poorer Survival. Royds JA, Al Nadaf S, Wiles AK, Chen YJ, Ahn A, Shaw A, Bowie S, Lam F, Baguley BC, Braithwaite AW, Macfarlane MR, Hung NA, Slatter TL. Source Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand. GoodScienceForYou 4 days ago @GoodScienceForYou It's great that you can spam with a whole lot of journals without actually showing me where they prove that research "only shows genetic losses in all complex creatures." TheDcac 4 days ago 7 @TheDcac Your statement shows you don't have a clue about science. This is my paper on science, backed by over 90,000 papers of DNA research. That is how science works. GoodScienceForYou 4 days ago @GoodScienceForYou Once again, a quote, with the page number, that distinctly says that research only shows degradation of the genome of all complex creatures. TheDcac 4 days ago @GoodScienceForYou "Your statement shows you don't have a clue about science. This is my paper on science, backed by over 90,000 papers of DNA research. That is how science works. " YOU are the one with no understanding of science. You have not published any peer-reviewed paper and comments on YouTube are not the equivalent. You have NOT read 90,000 papers on DNA research and, if you ever do, it will not take the place of experiment. Learn SOMETHING about science, you ignorant old fool. AlanCFA 3 days ago There are over 90,000 articles alone on the PubMed site on genetic losses. There are about 4 known positive mutations. The number of points in DNA that are screwed up in humans shows absolutely there in no possible positive evolution. That means all creatures came from a superior parent of the genetic lineage with designed in completed DNA made to work for many environments, foods, and conditions. GoodScienceForYou 4 days ago @GoodScienceForYou "There are about 4 known positive mutations." That is a blatant lie. I have posted many citations to studies showing you that there are many beneficial mutations. You simply LIE and make your ludicrous claims. You ARE a creationist and you advance nonsense arguments to support your religious worldview. "The number of points in DNA that are screwed up in humans shows absolutely there in no possible positive evolution" Complete supposition with no support from you. AlanCFA 3 days ago @AlanCFA There are 4 known positive mutations in humans. DNA is absolutely irrefutable physical evidence that only shows genetic losses in all complex creatures as the NET outcome of any form of mutations. You cannot refute absolute evidence. I am sorry for you. There is no evolution. We were designed and were far more fit in the original parent of the human genus. This is what the absolute evidence shows. GoodScienceForYou 3 days ago @GoodScienceForYou I've been following this discussion with great interest. Recently some early homo sapiens remains were found in Southern England and in the article I read it stated how early homo sapiens were generally taller than we are today and had larger brains. Which seems to me powerful evidence of how the human species has actually undergone physiological deterioration over the millenia. atticana 3 days ago @atticana There is more evidence of this. The Herto and the Orrorin tugenensis has an exact bone alignment to modern humans but a much strong femur; straight and much thicker bone. The sins of the father are passed on in genetic deterioration, emotional garbage, and in mental delusions. It takes a special person to get free of this and recognize that when we "fell" it means we started on this path of "sin". If you study the bible it is ALL
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